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Q5R7W8

- BT2A2_PONAB

UniProt

Q5R7W8 - BT2A2_PONAB

Protein

Butyrophilin subfamily 2 member A2

Gene

BTN2A2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.By similarity

    GO - Biological processi

    1. negative regulation of activated T cell proliferation Source: UniProtKB
    2. negative regulation of cellular metabolic process Source: UniProtKB
    3. negative regulation of cytokine secretion Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Butyrophilin subfamily 2 member A2
    Gene namesi
    Name:BTN2A2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 528499Butyrophilin subfamily 2 member A2PRO_0000367055Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi52 ↔ 126PROSITE-ProRule annotation
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R7W8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 249220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini271 – 528258CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei250 – 27021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 142112Ig-like V-typeAdd
    BLAST
    Domaini150 – 23283Ig-like C2-typeAdd
    BLAST
    Domaini311 – 507197B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili270 – 32051Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000230860.
    HOVERGENiHBG050747.
    KOiK06712.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00409. IG. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R7W8-1 [UniParc]FASTAAdd to Basket

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    MESAAALHFS RPASLLLLLL LSLCALVSAQ VTVVGPTDPI LGMVGENTTL    50
    RCHLSPEKNA EDMEVRWFRS QFSPAVFVYK GGRERTEEQM EEYRGRTTFV 100
    SKDISRGSVA LVIHNITAQE NGTYRCYFQE GRSYDEAILH LIVAGLGSKP 150
    LIEMRGHEDG GIRLECISRG WYPKPLTVWR DPYGGVVPAL KEVSMPDADS 200
    LFMVTTAVII RDKSVRNMFC SINNTLLSQK KESVIFIPES FMPSVSPCAV 250
    ALPIVVVILM ILFAVCMYWI NKLQKEKKIL SGEKEFERET REIAVKELEK 300
    ERVQKEEELQ VKEKLQEELR WRRTFLHAVD VVLDPDTAHP DLFLSEDRRS 350
    VRRRPFRHLG ESMPDNPERF NSQPCVLGRE SFASGKHYWE VEVENVIEWT 400
    VGVCRDSVER KGEVLLIPQN GFWTLEMHKS QYRAVSSPDR IIPLKESLCR 450
    VGVFLDYEAG DVSFYNMRDR SHIYTCPRSA FSVPVRPFFR LGCEDSPIFI 500
    CPALTGANGV TVPEEGLTLH RVGTHQSL 528
    Length:528
    Mass (Da):60,060
    Last modified:December 21, 2004 - v1
    Checksum:i818C23F038FE4E66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859991 mRNA. Translation: CAH92142.1.
    RefSeqiNP_001126252.1. NM_001132780.1.
    UniGeneiPab.4390.

    Genome annotation databases

    GeneIDi100173224.
    KEGGipon:100173224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859991 mRNA. Translation: CAH92142.1 .
    RefSeqi NP_001126252.1. NM_001132780.1.
    UniGenei Pab.4390.

    3D structure databases

    ProteinModelPortali Q5R7W8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100173224.
    KEGGi pon:100173224.

    Organism-specific databases

    CTDi 11120.

    Phylogenomic databases

    HOGENOMi HOG000230860.
    HOVERGENi HBG050747.
    KOi K06712.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00409. IG. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiBT2A2_PONAB
    AccessioniPrimary (citable) accession number: Q5R7W8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3