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Q5R7W8

- BT2A2_PONAB

UniProt

Q5R7W8 - BT2A2_PONAB

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Protein
Butyrophilin subfamily 2 member A2
Gene
BTN2A2
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion By similarity.

GO - Biological processi

  1. negative regulation of activated T cell proliferation Source: UniProtKB
  2. negative regulation of cellular metabolic process Source: UniProtKB
  3. negative regulation of cytokine secretion Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 2 member A2
Gene namesi
Name:BTN2A2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 249220Extracellular Reviewed prediction
Add
BLAST
Transmembranei250 – 27021Helical; Reviewed prediction
Add
BLAST
Topological domaini271 – 528258Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 528499Butyrophilin subfamily 2 member A2
PRO_0000367055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi52 ↔ 126 By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5R7W8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 142112Ig-like V-type
Add
BLAST
Domaini150 – 23283Ig-like C2-type
Add
BLAST
Domaini311 – 507197B30.2/SPRY
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili270 – 32051 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000230860.
HOVERGENiHBG050747.
KOiK06712.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R7W8-1 [UniParc]FASTAAdd to Basket

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MESAAALHFS RPASLLLLLL LSLCALVSAQ VTVVGPTDPI LGMVGENTTL    50
RCHLSPEKNA EDMEVRWFRS QFSPAVFVYK GGRERTEEQM EEYRGRTTFV 100
SKDISRGSVA LVIHNITAQE NGTYRCYFQE GRSYDEAILH LIVAGLGSKP 150
LIEMRGHEDG GIRLECISRG WYPKPLTVWR DPYGGVVPAL KEVSMPDADS 200
LFMVTTAVII RDKSVRNMFC SINNTLLSQK KESVIFIPES FMPSVSPCAV 250
ALPIVVVILM ILFAVCMYWI NKLQKEKKIL SGEKEFERET REIAVKELEK 300
ERVQKEEELQ VKEKLQEELR WRRTFLHAVD VVLDPDTAHP DLFLSEDRRS 350
VRRRPFRHLG ESMPDNPERF NSQPCVLGRE SFASGKHYWE VEVENVIEWT 400
VGVCRDSVER KGEVLLIPQN GFWTLEMHKS QYRAVSSPDR IIPLKESLCR 450
VGVFLDYEAG DVSFYNMRDR SHIYTCPRSA FSVPVRPFFR LGCEDSPIFI 500
CPALTGANGV TVPEEGLTLH RVGTHQSL 528
Length:528
Mass (Da):60,060
Last modified:December 21, 2004 - v1
Checksum:i818C23F038FE4E66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859991 mRNA. Translation: CAH92142.1.
RefSeqiNP_001126252.1. NM_001132780.1.
UniGeneiPab.4390.

Genome annotation databases

GeneIDi100173224.
KEGGipon:100173224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859991 mRNA. Translation: CAH92142.1 .
RefSeqi NP_001126252.1. NM_001132780.1.
UniGenei Pab.4390.

3D structure databases

ProteinModelPortali Q5R7W8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100173224.
KEGGi pon:100173224.

Organism-specific databases

CTDi 11120.

Phylogenomic databases

HOGENOMi HOG000230860.
HOVERGENi HBG050747.
KOi K06712.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiBT2A2_PONAB
AccessioniPrimary (citable) accession number: Q5R7W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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