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Q5R7W8 (BT2A2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Butyrophilin subfamily 2 member A2
Gene names
Name:BTN2A2
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 B30.2/SPRY domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 528499Butyrophilin subfamily 2 member A2
PRO_0000367055

Regions

Topological domain30 – 249220Extracellular Potential
Transmembrane250 – 27021Helical; Potential
Topological domain271 – 528258Cytoplasmic Potential
Domain31 – 142112Ig-like V-type
Domain150 – 23283Ig-like C2-type
Domain311 – 507197B30.2/SPRY
Coiled coil270 – 32051 Potential

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Disulfide bond52 ↔ 126 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R7W8 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 818C23F038FE4E66

FASTA52860,060
        10         20         30         40         50         60 
MESAAALHFS RPASLLLLLL LSLCALVSAQ VTVVGPTDPI LGMVGENTTL RCHLSPEKNA 

        70         80         90        100        110        120 
EDMEVRWFRS QFSPAVFVYK GGRERTEEQM EEYRGRTTFV SKDISRGSVA LVIHNITAQE 

       130        140        150        160        170        180 
NGTYRCYFQE GRSYDEAILH LIVAGLGSKP LIEMRGHEDG GIRLECISRG WYPKPLTVWR 

       190        200        210        220        230        240 
DPYGGVVPAL KEVSMPDADS LFMVTTAVII RDKSVRNMFC SINNTLLSQK KESVIFIPES 

       250        260        270        280        290        300 
FMPSVSPCAV ALPIVVVILM ILFAVCMYWI NKLQKEKKIL SGEKEFERET REIAVKELEK 

       310        320        330        340        350        360 
ERVQKEEELQ VKEKLQEELR WRRTFLHAVD VVLDPDTAHP DLFLSEDRRS VRRRPFRHLG 

       370        380        390        400        410        420 
ESMPDNPERF NSQPCVLGRE SFASGKHYWE VEVENVIEWT VGVCRDSVER KGEVLLIPQN 

       430        440        450        460        470        480 
GFWTLEMHKS QYRAVSSPDR IIPLKESLCR VGVFLDYEAG DVSFYNMRDR SHIYTCPRSA 

       490        500        510        520 
FSVPVRPFFR LGCEDSPIFI CPALTGANGV TVPEEGLTLH RVGTHQSL 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR859991 mRNA. Translation: CAH92142.1.
RefSeqNP_001126252.1. NM_001132780.1.
UniGenePab.4390.

3D structure databases

ProteinModelPortalQ5R7W8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173224.
KEGGpon:100173224.

Organism-specific databases

CTD11120.

Phylogenomic databases

HOGENOMHOG000230860.
HOVERGENHBG050747.
KOK06712.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBT2A2_PONAB
AccessionPrimary (citable) accession number: Q5R7W8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families