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Protein

Voltage-dependent anion-selective channel protein 3

Gene

VDAC3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi243 – 245NADBy similarity3
Nucleotide bindingi261 – 265NADBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

NAD, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 3
Short name:
VDAC-3
Gene namesi
Name:VDAC3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 35Beta strandedBy similarity10
Transmembranei39 – 48Beta strandedBy similarity10
Transmembranei55 – 65Beta strandedBy similarityAdd BLAST11
Transmembranei70 – 77Beta strandedBy similarity8
Transmembranei81 – 90Beta strandedBy similarity10
Transmembranei96 – 105Beta strandedBy similarity10
Transmembranei112 – 121Beta strandedBy similarity10
Transmembranei124 – 131Beta strandedBy similarity8
Transmembranei138 – 146Beta strandedBy similarity9
Transmembranei151 – 159Beta strandedBy similarity9
Transmembranei164 – 176Beta strandedBy similarityAdd BLAST13
Transmembranei179 – 186Beta strandedBy similarity8
Transmembranei190 – 199Beta strandedBy similarity10
Transmembranei203 – 212Beta strandedBy similarity10
Transmembranei219 – 228Beta strandedBy similarity10
Transmembranei232 – 239Beta strandedBy similarity8
Transmembranei243 – 252Beta strandedBy similarity10
Transmembranei255 – 264Beta strandedBy similarity10
Transmembranei274 – 283Beta strandedBy similarity10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000505152 – 284Voltage-dependent anion-selective channel protein 3Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineBy similarity1
Modified residuei4PhosphothreonineBy similarity1
Modified residuei20N6-acetyllysine; alternateBy similarity1
Modified residuei20N6-succinyllysine; alternateBy similarity1
Cross-linki54Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei68PhosphotyrosineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei108PhosphothreonineBy similarity1
Modified residuei110N6-acetyllysine; alternateBy similarity1
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei242PhosphoserineBy similarity1
Modified residuei267N6-acetyllysine; alternateBy similarity1
Cross-linki267Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

Post-translational modificationi

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ5R7V4.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000020808.

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOVERGENiHBG054036.
InParanoidiQ5R7V4.
KOiK15041.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R7V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVM EFSTSGHAYT
60 70 80 90 100
DTGKASGNLE TKYKVRNYGL TFTQKWNTDN TLGTEISWEN KLAEGLKLTL
110 120 130 140 150
DTIFVPNTGK KSGKLKASYK RDCFSVGSNV DIDFSGPTIY GWAVLAFEGW
160 170 180 190 200
LAGYQMSFDT AKSKLSQNNF ALGYKAADFQ LHTHVNDGTE FGGSIYQKVN
210 220 230 240 250
EKIETSINLA WTAGSNNTRF GIAAKYMLDC RTSLSAKVNN ASLIGLGYTQ
260 270 280
TLRPGVKLTL SALIDGKNFS AGGHKVGLGF ELEA
Length:284
Mass (Da):30,843
Last modified:December 21, 2004 - v1
Checksum:i608F4A6D359DB008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860005 mRNA. Translation: CAH92156.1.
RefSeqiNP_001127515.1. NM_001134043.1.
UniGeneiPab.6677.

Genome annotation databases

GeneIDi100174591.
KEGGipon:100174591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860005 mRNA. Translation: CAH92156.1.
RefSeqiNP_001127515.1. NM_001134043.1.
UniGeneiPab.6677.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000020808.

Proteomic databases

PRIDEiQ5R7V4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174591.
KEGGipon:100174591.

Organism-specific databases

CTDi7419.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOVERGENiHBG054036.
InParanoidiQ5R7V4.
KOiK15041.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC3_PONAB
AccessioniPrimary (citable) accession number: Q5R7V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.