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Protein

Voltage-dependent anion-selective channel protein 3

Gene

VDAC3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2453NADBy similarity
Nucleotide bindingi261 – 2655NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

NAD, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 3
Short name:
VDAC-3
Gene namesi
Name:VDAC3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 3510Beta strandedBy similarity
Transmembranei39 – 4810Beta strandedBy similarity
Transmembranei55 – 6511Beta strandedBy similarityAdd
BLAST
Transmembranei70 – 778Beta strandedBy similarity
Transmembranei81 – 9010Beta strandedBy similarity
Transmembranei96 – 10510Beta strandedBy similarity
Transmembranei112 – 12110Beta strandedBy similarity
Transmembranei124 – 1318Beta strandedBy similarity
Transmembranei138 – 1469Beta strandedBy similarity
Transmembranei151 – 1599Beta strandedBy similarity
Transmembranei164 – 17613Beta strandedBy similarityAdd
BLAST
Transmembranei179 – 1868Beta strandedBy similarity
Transmembranei190 – 19910Beta strandedBy similarity
Transmembranei203 – 21210Beta strandedBy similarity
Transmembranei219 – 22810Beta strandedBy similarity
Transmembranei232 – 2398Beta strandedBy similarity
Transmembranei243 – 25210Beta strandedBy similarity
Transmembranei255 – 26410Beta strandedBy similarity
Transmembranei274 – 28310Beta strandedBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 284283Voltage-dependent anion-selective channel protein 3PRO_0000050515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteineBy similarity
Modified residuei4 – 41PhosphothreonineBy similarity
Modified residuei20 – 201N6-acetyllysine; alternateBy similarity
Modified residuei20 – 201N6-succinyllysine; alternateBy similarity
Cross-linki54 – 54Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei68 – 681PhosphotyrosineBy similarity
Modified residuei91 – 911N6-acetyllysineBy similarity
Modified residuei110 – 1101N6-acetyllysine; alternateBy similarity
Cross-linki110 – 110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki111 – 111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei242 – 2421PhosphoserineBy similarity
Cross-linki267 – 267Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ5R7V4.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000020808.

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOVERGENiHBG054036.
InParanoidiQ5R7V4.
KOiK15041.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R7V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVM EFSTSGHAYT
60 70 80 90 100
DTGKASGNLE TKYKVRNYGL TFTQKWNTDN TLGTEISWEN KLAEGLKLTL
110 120 130 140 150
DTIFVPNTGK KSGKLKASYK RDCFSVGSNV DIDFSGPTIY GWAVLAFEGW
160 170 180 190 200
LAGYQMSFDT AKSKLSQNNF ALGYKAADFQ LHTHVNDGTE FGGSIYQKVN
210 220 230 240 250
EKIETSINLA WTAGSNNTRF GIAAKYMLDC RTSLSAKVNN ASLIGLGYTQ
260 270 280
TLRPGVKLTL SALIDGKNFS AGGHKVGLGF ELEA
Length:284
Mass (Da):30,843
Last modified:December 21, 2004 - v1
Checksum:i608F4A6D359DB008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860005 mRNA. Translation: CAH92156.1.
RefSeqiNP_001127515.1. NM_001134043.1.
UniGeneiPab.6677.

Genome annotation databases

GeneIDi100174591.
KEGGipon:100174591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860005 mRNA. Translation: CAH92156.1.
RefSeqiNP_001127515.1. NM_001134043.1.
UniGeneiPab.6677.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000020808.

Proteomic databases

PRIDEiQ5R7V4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174591.
KEGGipon:100174591.

Organism-specific databases

CTDi7419.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOVERGENiHBG054036.
InParanoidiQ5R7V4.
KOiK15041.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC3_PONAB
AccessioniPrimary (citable) accession number: Q5R7V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.