Q5R7U4 (GBG2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene names

Name:

GNG2

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	71 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus) By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Acetylation Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 68	67	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2		PRO_0000042169
	Propeptide	69 – 71	3	Removed in mature form By similarity		PRO_0000042170
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	52	1	Phosphothreonine By similarity
	Modified residue	68	1	Cysteine methyl ester By similarity
	Lipidation	68	1	S-geranylgeranyl cysteine By similarity
Experimental info
	Sequence conflict	46	1	K → E in CAH91225. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5R7U4 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: EDB74E4135E7A37A	FASTA	71	7,850
	10 20 30 40 50 60 MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL LTPVPASENP 70 FREKKFFCAI L

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR859030 mRNA. Translation: CAH91225.1. CR860015 mRNA. Translation: CAH92166.1.
RefSeq	NP_001125723.1. NM_001132251.1.
UniGene	Pab.17974.
3D structure databases
ProteinModelPortal	Q5R7U4.
ModBase	Search...
Proteomic databases
PRIDE	Q5R7U4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000006867; ENSPPYP00000006605; ENSPPYG00000005812.
GeneID	100172647.
KEGG	pon:100172647.
Organism-specific databases
CTD	54331.
Phylogenomic databases
GeneTree	ENSGT00550000074352.
HOVERGEN	HBG014983.
InParanoid	Q5R7U4.
KO	K07826.
OMA	SYCEAHA.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GBG2_PONAB

Accession

Primary (citable) accession number: Q5R7U4
Secondary accession number(s): Q5RAI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 61 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program