Q5R7K1 (PHS2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pterin-4-alpha-carbinolamine dehydratase 2
Short name=PHS 2
EC=4.2.1.96

Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase 2

Gene names

Name:

PCBD2

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	117 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 By similarity. Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity By similarity.
Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Subunit structure	Homotetramer. Interacts with DYRK1B By similarity.
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Sequence caution	The sequence CAH92259.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 117	›117	Pterin-4-alpha-carbinolamine dehydratase 2		PRO_0000228719
Amino acid modifications
	Modified residue	112	1	N6-acetyllysine By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q5R7K1 [UniParc]. Last modified June 16, 2009. Version 3. Checksum: CB9C55AC2463713E	FASTA	117	13,142
	10 20 30 40 50 60 LLAALRGQSL GLAAMSSGTH RLTPEERNQA ILDLKAAGWS ELSERDAIYK EFSFRNFNQA 70 80 90 100 110 FGFMSRVALQ AEKMNHHPEW FNVYNKVQIT LTSHDCGELT KKDVKLAQFI EKAAASV

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860114 mRNA. Translation: CAH92259.1. Different initiation.
UniGene	Pab.816.
3D structure databases
ProteinModelPortal	Q5R7K1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000018372; ENSPPYP00000017661; ENSPPYG00000015795. ENSPPYT00000018373; ENSPPYP00000017662; ENSPPYG00000015795.
Phylogenomic databases
HOVERGEN	HBG000259.
InParanoid	Q5R7K1.
Family and domain databases
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
SUPFAM	SSF55248. Trans_pterinDh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHS2_PONAB

Accession

Primary (citable) accession number: Q5R7K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	June 16, 2009
Last modified:	September 21, 2011
This is version 31 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program