Reviewed, UniProtKB/Swiss-Prot Q5R7K1 (PHS2_PONAB)

Names and origin

Protein names

Recommended name:
    Pterin-4-alpha-carbinolamine dehydratase 2
      Short name=PHS 2
    EC=4.2.1.96
Alternative name(s):
    4-alpha-hydroxy-tetrahydropterin dehydratase 2

Gene names

Name:

PCBD2

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	117 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 By similarity. Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity By similarity.
Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Subunit structure	Homotetramer. Interacts with DYRK1B By similarity.
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 117	›117	Pterin-4-alpha-carbinolamine dehydratase 2		PRO_0000228719
Amino acid modifications
	Modified residue	112	1	N6-acetyllysine By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q5R7K1-1 [UniParc]. Last modified June 16, 2009. Version 3. Checksum: CB9C55AC2463713E	FASTA	117	13,142
	10 20 30 40 50 60 LLAALRGQSL GLAAMSSGTH RLTPEERNQA ILDLKAAGWS ELSERDAIYK EFSFRNFNQA 70 80 90 100 110 FGFMSRVALQ AEKMNHHPEW FNVYNKVQIT LTSHDCGELT KKDVKLAQFI EKAAASV

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860114 mRNA. Translation: CAH92259.1. Different initiation.
UniGene	Pab.816
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q5R7K1.
Enzyme and pathway databases
BRENDA	4.2.1.96. 269192.
Family and domain databases
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
ProDom	PD007262. Trans_pterinDh. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

PHS2_PONAB

Accession

Primary (citable) accession number: Q5R7K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	June 16, 2009
Last modified:	October 13, 2009
This is version 23 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)