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Q5R7J8

- TP4A1_PONAB

UniProt

Q5R7J8 - TP4A1_PONAB

Protein

Protein tyrosine phosphatase type IVA 1

Gene

PTP4A1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Enzyme regulationi

    Inhibited by sodium orthovanadate and pentamidine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721Proton donorBy similarity
    Active sitei104 – 1041Phosphocysteine intermediateBy similarity
    Binding sitei110 – 1101SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein tyrosine phosphatase type IVA 1 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 4a1
    Protein-tyrosine phosphatase of regenerating liver 1
    Short name:
    PRL-1
    Gene namesi
    Name:PTP4A1
    Synonyms:PRL1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Cell membrane By similarity. Early endosome By similarity. Endoplasmic reticulum By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity
    Note: And mitotic spindle.By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell
    4. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Protein tyrosine phosphatase type IVA 1PRO_0000094783Add
    BLAST
    Propeptidei171 – 1733Removed in mature formBy similarityPRO_0000396729

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 104By similarity
    Modified residuei170 – 1701Cysteine methyl esterBy similarity
    Lipidationi170 – 1701S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Farnesylated. Farnesylation is required for membrane targeting By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with ATF5 and tubulin By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R7J8.
    SMRiQ5R7J8. Positions 9-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 14867Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 13236Interaction with ATF5By similarityAdd
    BLAST
    Regioni105 – 1106Phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG071295.
    InParanoidiQ5R7J8.
    KOiK18041.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R7J8-1 [UniParc]FASTAAdd to Basket

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    MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE    50
    ATYDTALVEK EGIHVLDWPF DDGAPPSNQI VDGWLSLVKI KFREEPGCCI 100
    AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE 150
    KYRPKMRLRF KDSNGHRNNC CIQ 173
    Length:173
    Mass (Da):19,727
    Last modified:December 21, 2004 - v1
    Checksum:i5FF00B273E00A186
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860117 mRNA. Translation: CAH92262.1.
    RefSeqiNP_001126324.1. NM_001132852.1.
    UniGeneiPab.863.

    Genome annotation databases

    GeneIDi100173305.
    KEGGipon:100173305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860117 mRNA. Translation: CAH92262.1 .
    RefSeqi NP_001126324.1. NM_001132852.1.
    UniGenei Pab.863.

    3D structure databases

    ProteinModelPortali Q5R7J8.
    SMRi Q5R7J8. Positions 9-160.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100173305.
    KEGGi pon:100173305.

    Organism-specific databases

    CTDi 7803.

    Phylogenomic databases

    HOVERGENi HBG071295.
    InParanoidi Q5R7J8.
    KOi K18041.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiTP4A1_PONAB
    AccessioniPrimary (citable) accession number: Q5R7J8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3