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Q5R7J8 (TP4A1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein tyrosine phosphatase type IVA 1

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Short name=PRL-1
Gene names
Name:PTP4A1
Synonyms:PRL1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulation

Inhibited by sodium orthovanadate and pentamidine By similarity.

Subunit structure

Homotrimer. Interacts with ATF5 and tubulin By similarity.

Subcellular location

Cell membrane By similarity. Early endosome By similarity. Endoplasmic reticulum By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity. Note: And mitotic spindle By similarity.

Post-translational modification

Farnesylated. Farnesylation is required for membrane targeting By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Protein tyrosine phosphatase type IVA 1
PRO_0000094783
Propeptide171 – 1733Removed in mature form By similarity
PRO_0000396729

Regions

Domain82 – 14867Tyrosine-protein phosphatase
Region97 – 13236Interaction with ATF5 By similarity
Region105 – 1106Phosphate binding By similarity

Sites

Active site721Proton donor By similarity
Active site1041Phosphocysteine intermediate By similarity
Binding site1101Substrate By similarity

Amino acid modifications

Modified residue1701Cysteine methyl ester By similarity
Lipidation1701S-farnesyl cysteine By similarity
Disulfide bond49 ↔ 104 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R7J8 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 5FF00B273E00A186

FASTA17319,727
        10         20         30         40         50         60 
MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTALVEK 

        70         80         90        100        110        120 
EGIHVLDWPF DDGAPPSNQI VDGWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI 

       130        140        150        160        170 
EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860117 mRNA. Translation: CAH92262.1.
RefSeqNP_001126324.1. NM_001132852.1.
UniGenePab.863.

3D structure databases

ProteinModelPortalQ5R7J8.
SMRQ5R7J8. Positions 9-160.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173305.
KEGGpon:100173305.

Organism-specific databases

CTD7803.

Phylogenomic databases

HOVERGENHBG071295.
InParanoidQ5R7J8.
KOK18041.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTP4A1_PONAB
AccessionPrimary (citable) accession number: Q5R7J8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families