Q5R7J8 (TP4A1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein tyrosine phosphatase type IVA 1
EC=3.1.3.48

Alternative name(s):
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Short name=PRL-1

Gene names

Name:	PTP4A1
Synonyms:	PRL1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Enzyme regulation	Inhibited by sodium orthovanadate and pentamidine By similarity.
Subunit structure	Homotrimer. Interacts with ATF5 and tubulin By similarity.
Subcellular location	Cell membrane By similarity. Early endosome By similarity. Endoplasmic reticulum By similarity. Cytoplasm By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Note: And mitotic spindle By similarity.
Post-translational modification	Farnesylated. Farnesylation is required for membrane targeting By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cell membrane Cytoplasm Cytoskeleton Endoplasmic reticulum Endosome Membrane
Molecular function	Developmental protein Hydrolase Protein phosphatase
PTM	Disulfide bond Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Protein tyrosine phosphatase type IVA 1		PRO_0000094783
	Propeptide	171 – 173	3	Removed in mature form By similarity		PRO_0000396729
Regions
	Domain	82 – 148	67	Tyrosine-protein phosphatase
	Region	97 – 132	36	Interaction with ATF5 By similarity
	Region	105 – 110	6	Phosphate binding By similarity
Sites
	Active site	72	1	Proton donor By similarity
	Active site	104	1	Phosphocysteine intermediate By similarity
	Binding site	110	1	Substrate By similarity
Amino acid modifications
	Modified residue	170	1	Cysteine methyl ester By similarity
	Lipidation	170	1	S-farnesyl cysteine By similarity
	Disulfide bond	49 ↔ 104		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R7J8 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 5FF00B273E00A186	FASTA	173	19,727
	10 20 30 40 50 60 MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTALVEK 70 80 90 100 110 120 EGIHVLDWPF DDGAPPSNQI VDGWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI 130 140 150 160 170 EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860117 mRNA. Translation: CAH92262.1.
RefSeq	NP_001126324.1. NM_001132852.1.
UniGene	Pab.863.
3D structure databases
ProteinModelPortal	Q5R7J8.
SMR	Q5R7J8. Positions 9-160.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100173305.
KEGG	pon:100173305.
Organism-specific databases
CTD	7803.
Phylogenomic databases
HOVERGEN	HBG071295.
InParanoid	Q5R7J8.
KO	K01104.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TP4A1_PONAB

Accession

Primary (citable) accession number: Q5R7J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program