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Q5R7I7 (CDK20_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 20

EC=2.7.11.22
Alternative name(s):
Cell cycle-related kinase
Cell division protein kinase 20
Gene names
Name:CDK20
Synonyms:CCRK
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Monomer By similarity. Interacts with TBC1D32 and MAK By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Cyclin-dependent kinase 20
PRO_0000085704

Regions

Domain4 – 288285Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R7I7 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 026647C40CAD5704

FASTA34638,723
        10         20         30         40         50         60 
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEMED 

        70         80         90        100        110        120 
NQYVVQLKAV FPHSAGFVLA FEFMLSDLAE VVRHAQRPLA QAQVKSYLQM LLKGVSFCHA 

       130        140        150        160        170        180 
NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGSRLY THQVATRWYR APELLYGARQ 

       190        200        210        220        230        240 
YDQGVDLWAV GCIMGELLNG SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI 

       250        260        270        280        290        300 
SFKEQAPVPL EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS KALLHQYFFT APLPAHPSEL 

       310        320        330        340 
PIPQRLGVPA PKAHPGPPRI HDFYVDRPLE ESLLNPELIR PFILEG 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860129 mRNA. Translation: CAH92273.1.
RefSeqNP_001126328.1. NM_001132856.1.
UniGenePab.6896.

3D structure databases

ProteinModelPortalQ5R7I7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000022572; ENSPPYP00000021685; ENSPPYG00000019353.
GeneID100173309.
KEGGpon:100173309.

Organism-specific databases

CTD23552.

Phylogenomic databases

GeneTreeENSGT00740000115348.
HOVERGENHBG014652.
InParanoidQ5R7I7.
KOK08817.
OMAAFTHGVP.
OrthoDBEOG75J0NH.
TreeFamTF327240.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK20_PONAB
AccessionPrimary (citable) accession number: Q5R7I7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families