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Protein

Cyclin-dependent kinase 20

Gene

CDK20

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 20 (EC:2.7.11.22)
Alternative name(s):
Cell cycle-related kinase
Cell division protein kinase 20
Gene namesi
Name:CDK20
Synonyms:CCRK
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Chromosome 9

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity

GO - Cellular componenti

  1. cilium Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Cyclin-dependent kinase 20PRO_0000085704Add
BLAST

Interactioni

Subunit structurei

Monomer. Interacts with TBC1D32 and MAK.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5R7I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 288285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119242.
HOVERGENiHBG014652.
InParanoidiQ5R7I7.
KOiK08817.
OMAiAFTHGVP.
OrthoDBiEOG75J0NH.
TreeFamiTF327240.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R7I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR
60 70 80 90 100
EIKALQEMED NQYVVQLKAV FPHSAGFVLA FEFMLSDLAE VVRHAQRPLA
110 120 130 140 150
QAQVKSYLQM LLKGVSFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR
160 170 180 190 200
VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWAV GCIMGELLNG
210 220 230 240 250
SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQAPVPL
260 270 280 290 300
EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS KALLHQYFFT APLPAHPSEL
310 320 330 340
PIPQRLGVPA PKAHPGPPRI HDFYVDRPLE ESLLNPELIR PFILEG
Length:346
Mass (Da):38,723
Last modified:December 20, 2004 - v1
Checksum:i026647C40CAD5704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860129 mRNA. Translation: CAH92273.1.
RefSeqiNP_001126328.1. NM_001132856.1.
UniGeneiPab.6896.

Genome annotation databases

EnsembliENSPPYT00000022572; ENSPPYP00000021685; ENSPPYG00000019353.
GeneIDi100173309.
KEGGipon:100173309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860129 mRNA. Translation: CAH92273.1.
RefSeqiNP_001126328.1. NM_001132856.1.
UniGeneiPab.6896.

3D structure databases

ProteinModelPortaliQ5R7I7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000022572; ENSPPYP00000021685; ENSPPYG00000019353.
GeneIDi100173309.
KEGGipon:100173309.

Organism-specific databases

CTDi23552.

Phylogenomic databases

GeneTreeiENSGT00760000119242.
HOVERGENiHBG014652.
InParanoidiQ5R7I7.
KOiK08817.
OMAiAFTHGVP.
OrthoDBiEOG75J0NH.
TreeFamiTF327240.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCDK20_PONAB
AccessioniPrimary (citable) accession number: Q5R7I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2005
Last sequence update: December 20, 2004
Last modified: January 6, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.