Q5R7I7 (CDK20_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 20
EC=2.7.11.22

Alternative name(s):
Cell cycle-related kinase
Cell division protein kinase 20

Gene names

Name:	CDK20
Synonyms:	CCRK

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Monomer By similarity. Interacts with BROMI and MAK By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Cell projection › cilium By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell projection Cilium Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cilium Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Cyclin-dependent kinase 20		PRO_0000085704
Regions
	Domain	4 – 288	285	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	127	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R7I7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 026647C40CAD5704	FASTA	346	38,723
	10 20 30 40 50 60 MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEMED 70 80 90 100 110 120 NQYVVQLKAV FPHSAGFVLA FEFMLSDLAE VVRHAQRPLA QAQVKSYLQM LLKGVSFCHA 130 140 150 160 170 180 NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGSRLY THQVATRWYR APELLYGARQ 190 200 210 220 230 240 YDQGVDLWAV GCIMGELLNG SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI 250 260 270 280 290 300 SFKEQAPVPL EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS KALLHQYFFT APLPAHPSEL 310 320 330 340 PIPQRLGVPA PKAHPGPPRI HDFYVDRPLE ESLLNPELIR PFILEG

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860129 mRNA. Translation: CAH92273.1.
RefSeq	NP_001126328.1. NM_001132856.1.
UniGene	Pab.6896.
3D structure databases
ProteinModelPortal	Q5R7I7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000022572; ENSPPYP00000021685; ENSPPYG00000019353.
GeneID	100173309.
KEGG	pon:100173309.
Organism-specific databases
CTD	23552.
Phylogenomic databases
GeneTree	ENSGT00680000099989.
HOVERGEN	HBG014652.
InParanoid	Q5R7I7.
KO	K08817.
OMA	AFTHGVP.
OrthoDB	EOG4DBTDX.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK20_PONAB

Accession

Primary (citable) accession number: Q5R7I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program