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Q5R7I7

- CDK20_PONAB

UniProt

Q5R7I7 - CDK20_PONAB

Protein

Cyclin-dependent kinase 20

Gene

CDK20

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 20 (EC:2.7.11.22)
    Alternative name(s):
    Cell cycle-related kinase
    Cell division protein kinase 20
    Gene namesi
    Name:CDK20
    Synonyms:CCRK
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 9

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity

    GO - Cellular componenti

    1. cilium Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Cyclin-dependent kinase 20PRO_0000085704Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Interacts with TBC1D32 and MAK.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R7I7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 288285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115348.
    HOVERGENiHBG014652.
    InParanoidiQ5R7I7.
    KOiK08817.
    OMAiRPFIPEG.
    OrthoDBiEOG75J0NH.
    TreeFamiTF327240.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5R7I7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR    50
    EIKALQEMED NQYVVQLKAV FPHSAGFVLA FEFMLSDLAE VVRHAQRPLA 100
    QAQVKSYLQM LLKGVSFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR 150
    VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWAV GCIMGELLNG 200
    SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQAPVPL 250
    EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS KALLHQYFFT APLPAHPSEL 300
    PIPQRLGVPA PKAHPGPPRI HDFYVDRPLE ESLLNPELIR PFILEG 346
    Length:346
    Mass (Da):38,723
    Last modified:December 21, 2004 - v1
    Checksum:i026647C40CAD5704
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860129 mRNA. Translation: CAH92273.1.
    RefSeqiNP_001126328.1. NM_001132856.1.
    UniGeneiPab.6896.

    Genome annotation databases

    EnsembliENSPPYT00000022572; ENSPPYP00000021685; ENSPPYG00000019353.
    GeneIDi100173309.
    KEGGipon:100173309.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860129 mRNA. Translation: CAH92273.1 .
    RefSeqi NP_001126328.1. NM_001132856.1.
    UniGenei Pab.6896.

    3D structure databases

    ProteinModelPortali Q5R7I7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000022572 ; ENSPPYP00000021685 ; ENSPPYG00000019353 .
    GeneIDi 100173309.
    KEGGi pon:100173309.

    Organism-specific databases

    CTDi 23552.

    Phylogenomic databases

    GeneTreei ENSGT00740000115348.
    HOVERGENi HBG014652.
    InParanoidi Q5R7I7.
    KOi K08817.
    OMAi RPFIPEG.
    OrthoDBi EOG75J0NH.
    TreeFami TF327240.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiCDK20_PONAB
    AccessioniPrimary (citable) accession number: Q5R7I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3