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Q5R7I7

- CDK20_PONAB

UniProt

Q5R7I7 - CDK20_PONAB

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Protein

Cyclin-dependent kinase 20

Gene
CDK20, CCRK
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 20 (EC:2.7.11.22)
Alternative name(s):
Cell cycle-related kinase
Cell division protein kinase 20
Gene namesi
Name:CDK20
Synonyms:CCRK
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 9

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity

GO - Cellular componenti

  1. cilium Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Cyclin-dependent kinase 20PRO_0000085704Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity. Interacts with TBC1D32 and MAK By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R7I7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 288285Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00740000115348.
HOVERGENiHBG014652.
InParanoidiQ5R7I7.
KOiK08817.
OMAiRPFIPEG.
OrthoDBiEOG75J0NH.
TreeFamiTF327240.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R7I7-1 [UniParc]FASTAAdd to Basket

« Hide

MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR    50
EIKALQEMED NQYVVQLKAV FPHSAGFVLA FEFMLSDLAE VVRHAQRPLA 100
QAQVKSYLQM LLKGVSFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR 150
VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWAV GCIMGELLNG 200
SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQAPVPL 250
EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS KALLHQYFFT APLPAHPSEL 300
PIPQRLGVPA PKAHPGPPRI HDFYVDRPLE ESLLNPELIR PFILEG 346
Length:346
Mass (Da):38,723
Last modified:December 21, 2004 - v1
Checksum:i026647C40CAD5704
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860129 mRNA. Translation: CAH92273.1.
RefSeqiNP_001126328.1. NM_001132856.1.
UniGeneiPab.6896.

Genome annotation databases

EnsembliENSPPYT00000022572; ENSPPYP00000021685; ENSPPYG00000019353.
GeneIDi100173309.
KEGGipon:100173309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860129 mRNA. Translation: CAH92273.1 .
RefSeqi NP_001126328.1. NM_001132856.1.
UniGenei Pab.6896.

3D structure databases

ProteinModelPortali Q5R7I7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000022572 ; ENSPPYP00000021685 ; ENSPPYG00000019353 .
GeneIDi 100173309.
KEGGi pon:100173309.

Organism-specific databases

CTDi 23552.

Phylogenomic databases

GeneTreei ENSGT00740000115348.
HOVERGENi HBG014652.
InParanoidi Q5R7I7.
KOi K08817.
OMAi RPFIPEG.
OrthoDBi EOG75J0NH.
TreeFami TF327240.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCDK20_PONAB
AccessioniPrimary (citable) accession number: Q5R7I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 21, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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