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Q5R7H0 (DHTK1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

EC=1.2.4.2
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene names
Name:DHTKD1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length919 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 919Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307938

Amino acid modifications

Modified residue1831N6-succinyllysine By similarity
Modified residue1881N6-succinyllysine By similarity
Modified residue8001N6-succinyllysine By similarity
Modified residue8181N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R7H0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 6F111B5B0A5A3198

FASTA919103,036
        10         20         30         40         50         60 
MASATAAAAR RCLGRAPPLL WRGYQTERGV YGYRPRKPES RKPQGALERP PVDHGLARLV 

        70         80         90        100        110        120 
TVYREHGHKA AKINPLFTGQ ALLENVPEIQ ALVQTLQGPF HTAGLLNMGK EEASLEEVLV 

       130        140        150        160        170        180 
YLNQIYCGQI SIETSQLQSQ EEKDWFAKRF EELQKETFTT EERKHLSKLM LESQEFDHFL 

       190        200        210        220        230        240 
ATKFSTVKRY GGEGAESMMG FFYELLKMSA YSGITDVIIG MPHRGRLNLL TGLLQFPPEL 

       250        260        270        280        290        300 
MFRKMRGLSE FPENFSATGD VLSHLTSSVD LDFGAHHPLH VTMLPNPSHL EAVNPVAVGK 

       310        320        330        340        350        360 
TRGRQQSRQD GDYSPDNSAQ PGDRVICLQV HGDASFCGQG IVPETFTLSN LPHFRIGGSV 

       370        380        390        400        410        420 
HLIVNNQLGY TTPAERGRSS LYCSDIGKLV GCAIIHVNGD SPEEVVRATR LAFEYQRQFR 

       430        440        450        460        470        480 
KDVIIDLLCY RQWGHNELDE PFFTNPIMYK IIRARKSIPD TYAEHLIAGG LMTQEEVSEI 

       490        500        510        520        530        540 
KSSYYAKLND HLNNMAHYSP PAQNLQAHWQ GLAQPEARIT TWSTGVPLDL LRFVGVKSVE 

       550        560        570        580        590        600 
VPRQLQMHSH LLKTHVQSRM EKVMDGTKLD WATAEALALG SLLAQGFNVR LSGQDVGRGT 

       610        620        630        640        650        660 
FSQRHAMVVC QETDDTYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM SIESPKLLPL 

       670        680        690        700        710        720 
WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGIVTLLPHG HDGAGPDHSS CRIERFLQMC 

       730        740        750        760        770        780 
DSAEEGVDGD TVNMFVVHPT TPAQYFHLLR RQMVRNFRKP LIVASPKMLL RLPAAVSTLQ 

       790        800        810        820        830        840 
EMAPGTTFNP VIGDSSVDPK KVKTLVFCSG KHFYSLMKQR ESLGAKKHDF AIIRVEELCP 

       850        860        870        880        890        900 
FPLDSLQQEM SKYKHVKDHI WSQEEPQNMG PWLFVSPRFE KQLACKLRLV GRPPLPVPAV 

       910 
GIGTVHLHQH EDILAKTFA 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860147 mRNA. Translation: CAH92290.1.
RefSeqNP_001126339.1. NM_001132867.1.

3D structure databases

ProteinModelPortalQ5R7H0.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R7H0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173320.
KEGGpon:100173320.

Organism-specific databases

CTD55526.

Phylogenomic databases

HOVERGENHBG001892.
InParanoidQ5R7H0.
KOK15791.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDHTK1_PONAB
AccessionPrimary (citable) accession number: Q5R7H0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families