Reviewed, UniProtKB/Swiss-Prot Q5R7H0 (DHTK1_PONAB)

Names and origin

Protein names

Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
    EC=1.2.4.2
Alternative name(s):
    Dehydrogenase E1 and transketolase domain-containing protein 1

Gene names

Name:

DHTKD1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	919 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Subcellular location	Mitochondrion Potential.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 919		Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial		PRO_0000307938

Sequences

	Sequence		Length	Mass (Da)
	Q5R7H0-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 6F111B5B0A5A3198	FASTA	919	103,036
	10 20 30 40 50 60 MASATAAAAR RCLGRAPPLL WRGYQTERGV YGYRPRKPES RKPQGALERP PVDHGLARLV 70 80 90 100 110 120 TVYREHGHKA AKINPLFTGQ ALLENVPEIQ ALVQTLQGPF HTAGLLNMGK EEASLEEVLV 130 140 150 160 170 180 YLNQIYCGQI SIETSQLQSQ EEKDWFAKRF EELQKETFTT EERKHLSKLM LESQEFDHFL 190 200 210 220 230 240 ATKFSTVKRY GGEGAESMMG FFYELLKMSA YSGITDVIIG MPHRGRLNLL TGLLQFPPEL 250 260 270 280 290 300 MFRKMRGLSE FPENFSATGD VLSHLTSSVD LDFGAHHPLH VTMLPNPSHL EAVNPVAVGK 310 320 330 340 350 360 TRGRQQSRQD GDYSPDNSAQ PGDRVICLQV HGDASFCGQG IVPETFTLSN LPHFRIGGSV 370 380 390 400 410 420 HLIVNNQLGY TTPAERGRSS LYCSDIGKLV GCAIIHVNGD SPEEVVRATR LAFEYQRQFR 430 440 450 460 470 480 KDVIIDLLCY RQWGHNELDE PFFTNPIMYK IIRARKSIPD TYAEHLIAGG LMTQEEVSEI 490 500 510 520 530 540 KSSYYAKLND HLNNMAHYSP PAQNLQAHWQ GLAQPEARIT TWSTGVPLDL LRFVGVKSVE 550 560 570 580 590 600 VPRQLQMHSH LLKTHVQSRM EKVMDGTKLD WATAEALALG SLLAQGFNVR LSGQDVGRGT 610 620 630 640 650 660 FSQRHAMVVC QETDDTYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM SIESPKLLPL 670 680 690 700 710 720 WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGIVTLLPHG HDGAGPDHSS CRIERFLQMC 730 740 750 760 770 780 DSAEEGVDGD TVNMFVVHPT TPAQYFHLLR RQMVRNFRKP LIVASPKMLL RLPAAVSTLQ 790 800 810 820 830 840 EMAPGTTFNP VIGDSSVDPK KVKTLVFCSG KHFYSLMKQR ESLGAKKHDF AIIRVEELCP 850 860 870 880 890 900 FPLDSLQQEM SKYKHVKDHI WSQEEPQNMG PWLFVSPRFE KQLACKLRLV GRPPLPVPAV 910 GIGTVHLHQH EDILAKTFA

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860147 mRNA. Translation: CAH92290.1.
RefSeq	NP_001126339.1.
UniGene	Pab.18818
3D structure databases
SMR	Q5R7H0. Positions 55-919.
ModBase	Search...
Genome annotation databases
GeneID	100173320.
Organism-specific databases
CTD	100173320.
Phylogenomic databases
HOVERGEN	Q5R7H0.
InParanoid	Q5R7H0.
Enzyme and pathway databases
BRENDA	1.2.4.2. 269192.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DHTK1_PONAB

Accession

Primary (citable) accession number: Q5R7H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 21, 2004
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)