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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

DHTKD1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. generation of precursor metabolites and energy Source: UniProtKB
  2. glycolytic process Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:DHTKD1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 919Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307938
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831N6-succinyllysineBy similarity
Modified residuei188 – 1881N6-succinyllysineBy similarity
Modified residuei800 – 8001N6-succinyllysineBy similarity
Modified residuei818 – 8181N6-succinyllysineBy similarity

Proteomic databases

PRIDEiQ5R7H0.

Structurei

3D structure databases

ProteinModelPortaliQ5R7H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001892.
InParanoidiQ5R7H0.
KOiK15791.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R7H0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASATAAAAR RCLGRAPPLL WRGYQTERGV YGYRPRKPES RKPQGALERP
60 70 80 90 100
PVDHGLARLV TVYREHGHKA AKINPLFTGQ ALLENVPEIQ ALVQTLQGPF
110 120 130 140 150
HTAGLLNMGK EEASLEEVLV YLNQIYCGQI SIETSQLQSQ EEKDWFAKRF
160 170 180 190 200
EELQKETFTT EERKHLSKLM LESQEFDHFL ATKFSTVKRY GGEGAESMMG
210 220 230 240 250
FFYELLKMSA YSGITDVIIG MPHRGRLNLL TGLLQFPPEL MFRKMRGLSE
260 270 280 290 300
FPENFSATGD VLSHLTSSVD LDFGAHHPLH VTMLPNPSHL EAVNPVAVGK
310 320 330 340 350
TRGRQQSRQD GDYSPDNSAQ PGDRVICLQV HGDASFCGQG IVPETFTLSN
360 370 380 390 400
LPHFRIGGSV HLIVNNQLGY TTPAERGRSS LYCSDIGKLV GCAIIHVNGD
410 420 430 440 450
SPEEVVRATR LAFEYQRQFR KDVIIDLLCY RQWGHNELDE PFFTNPIMYK
460 470 480 490 500
IIRARKSIPD TYAEHLIAGG LMTQEEVSEI KSSYYAKLND HLNNMAHYSP
510 520 530 540 550
PAQNLQAHWQ GLAQPEARIT TWSTGVPLDL LRFVGVKSVE VPRQLQMHSH
560 570 580 590 600
LLKTHVQSRM EKVMDGTKLD WATAEALALG SLLAQGFNVR LSGQDVGRGT
610 620 630 640 650
FSQRHAMVVC QETDDTYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM
660 670 680 690 700
SIESPKLLPL WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGIVTLLPHG
710 720 730 740 750
HDGAGPDHSS CRIERFLQMC DSAEEGVDGD TVNMFVVHPT TPAQYFHLLR
760 770 780 790 800
RQMVRNFRKP LIVASPKMLL RLPAAVSTLQ EMAPGTTFNP VIGDSSVDPK
810 820 830 840 850
KVKTLVFCSG KHFYSLMKQR ESLGAKKHDF AIIRVEELCP FPLDSLQQEM
860 870 880 890 900
SKYKHVKDHI WSQEEPQNMG PWLFVSPRFE KQLACKLRLV GRPPLPVPAV
910
GIGTVHLHQH EDILAKTFA
Length:919
Mass (Da):103,036
Last modified:December 21, 2004 - v1
Checksum:i6F111B5B0A5A3198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860147 mRNA. Translation: CAH92290.1.
RefSeqiNP_001126339.1. NM_001132867.1.

Genome annotation databases

GeneIDi100173320.
KEGGipon:100173320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860147 mRNA. Translation: CAH92290.1.
RefSeqiNP_001126339.1. NM_001132867.1.

3D structure databases

ProteinModelPortaliQ5R7H0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5R7H0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173320.
KEGGipon:100173320.

Organism-specific databases

CTDi55526.

Phylogenomic databases

HOVERGENiHBG001892.
InParanoidiQ5R7H0.
KOiK15791.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDHTK1_PONAB
AccessioniPrimary (citable) accession number: Q5R7H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.