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Protein

Lipid droplet-associated hydrolase

Gene

LDAH

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139NucleophilePROSITE-ProRule annotation1
Active sitei271Charge relay systemBy similarity1
Active sitei300Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERiponab-cb043. LIDHydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid droplet-associated hydrolaseBy similarity (EC:3.1.1.-By similarity)
Alternative name(s):
Lipid droplet-associated serine hydrolaseBy similarity
Gene namesi
Name:LDAHBy similarity
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003001261 – 325Lipid droplet-associated hydrolaseAdd BLAST325

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000014085.

Structurei

3D structure databases

ProteinModelPortaliQ5R7E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. LDAH family.Curated

Phylogenomic databases

eggNOGiKOG3975. Eukaryota.
ENOG410ZTV7. LUCA.
HOVERGENiHBG107578.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR019363. LDAH.
PANTHERiPTHR13390. PTHR13390. 1 hit.
PfamiView protein in Pfam
PF10230. LIDHydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00120. LIPASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFNDQSV KRPKLLIFII
60 70 80 90 100
PGNPGFSAFY VPFAKALYSL TNRCFPVWTI SHAGHALAPK DKKILTTSED
110 120 130 140 150
SNAQEIKDIY GLNGQIEHKL AFLRTHVPKD MKLVLIGHSV GSYFTLQMLK
160 170 180 190 200
RVPELPVIRA FLLFPTIERM SESPNGRIAT PLLCWSRYVL YVTGYLLLKP
210 220 230 240 250
CPEKIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAHL GGQEMMEVVK
260 270 280 290 300
RDDETIREHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
310 320
AFIIHFNQEM ADMIADSLKD DLSKM
Length:325
Mass (Da):37,209
Last modified:December 21, 2004 - v1
Checksum:i0FDD3277282FE853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860170 mRNA. Translation: CAH92312.1.
RefSeqiNP_001126355.1. NM_001132883.1.
UniGeneiPab.6696.

Genome annotation databases

GeneIDi100173336.
KEGGipon:100173336.

Similar proteinsi

Entry informationi

Entry nameiLDAH_PONAB
AccessioniPrimary (citable) accession number: Q5R7E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families