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Protein

Lipid droplet-associated hydrolase

Gene

LDAH

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391NucleophilePROSITE-ProRule annotation
Active sitei271 – 2711Charge relay systemBy similarity
Active sitei300 – 3001Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERiponab-cb043. Duf_2305.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid droplet-associated hydrolaseBy similarity (EC:3.1.1.-By similarity)
Alternative name(s):
Lipid droplet-associated serine hydrolaseBy similarity
Gene namesi
Name:LDAHBy similarity
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

  • Lipid droplet By similarity
  • Endoplasmic reticulum By similarity

  • Note: Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Lipid droplet-associated hydrolasePRO_0000300126Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000014085.

Structurei

3D structure databases

ProteinModelPortaliQ5R7E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. LDAH family.Curated

Phylogenomic databases

eggNOGiKOG3975. Eukaryota.
ENOG410ZTV7. LUCA.
HOVERGENiHBG107578.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR019363. LDAH.
[Graphical view]
PANTHERiPTHR13390. PTHR13390. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFNDQSV KRPKLLIFII
60 70 80 90 100
PGNPGFSAFY VPFAKALYSL TNRCFPVWTI SHAGHALAPK DKKILTTSED
110 120 130 140 150
SNAQEIKDIY GLNGQIEHKL AFLRTHVPKD MKLVLIGHSV GSYFTLQMLK
160 170 180 190 200
RVPELPVIRA FLLFPTIERM SESPNGRIAT PLLCWSRYVL YVTGYLLLKP
210 220 230 240 250
CPEKIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAHL GGQEMMEVVK
260 270 280 290 300
RDDETIREHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
310 320
AFIIHFNQEM ADMIADSLKD DLSKM
Length:325
Mass (Da):37,209
Last modified:December 21, 2004 - v1
Checksum:i0FDD3277282FE853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860170 mRNA. Translation: CAH92312.1.
RefSeqiNP_001126355.1. NM_001132883.1.
UniGeneiPab.6696.

Genome annotation databases

GeneIDi100173336.
KEGGipon:100173336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860170 mRNA. Translation: CAH92312.1.
RefSeqiNP_001126355.1. NM_001132883.1.
UniGeneiPab.6696.

3D structure databases

ProteinModelPortaliQ5R7E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000014085.

Protein family/group databases

ESTHERiponab-cb043. Duf_2305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173336.
KEGGipon:100173336.

Organism-specific databases

CTDi60526.

Phylogenomic databases

eggNOGiKOG3975. Eukaryota.
ENOG410ZTV7. LUCA.
HOVERGENiHBG107578.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR019363. LDAH.
[Graphical view]
PANTHERiPTHR13390. PTHR13390. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDAH_PONAB
AccessioniPrimary (citable) accession number: Q5R7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.