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Q5R7E3

- HMOX1_PONAB

UniProt

Q5R7E3 - HMOX1_PONAB

Protein

Heme oxygenase 1

Gene

HMOX1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis By similarity.By similarity

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei18 – 181HemeBy similarity
    Metal bindingi25 – 251Iron (heme axial ligand)
    Binding sitei134 – 1341HemeBy similarity
    Binding sitei183 – 1831HemeBy similarity

    GO - Molecular functioni

    1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. heme oxidation Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase 1 (EC:1.14.99.3)
    Short name:
    HO-1
    Gene namesi
    Name:HMOX1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Heme oxygenase 1PRO_0000317707Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei229 – 2291PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ5R7E3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R7E3.
    SMRiQ5R7E3. Positions 1-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000233221.
    HOVERGENiHBG005982.
    InParanoidiQ5R7E3.
    KOiK00510.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view]
    PANTHERiPTHR10720. PTHR10720. 1 hit.
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000343. Haem_Oase. 1 hit.
    PRINTSiPR00088. HAEMOXYGNASE.
    SUPFAMiSSF48613. SSF48613. 1 hit.
    PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5R7E3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTREGFKLV    50
    MASLYHIYVA LEEEIEHNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR 100
    WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI 150
    AQKALGLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI 200
    EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKAQDSAPV 250
    ETPRGKTPLN THSQAPLLRW VLTLSFLVAT VAVGLYAM 288
    Length:288
    Mass (Da):32,712
    Last modified:December 21, 2004 - v1
    Checksum:i10400CCCCA98F7F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860175 mRNA. Translation: CAH92317.1.
    RefSeqiNP_001126358.1. NM_001132886.1.

    Genome annotation databases

    GeneIDi100173339.
    KEGGipon:100173339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860175 mRNA. Translation: CAH92317.1 .
    RefSeqi NP_001126358.1. NM_001132886.1.

    3D structure databases

    ProteinModelPortali Q5R7E3.
    SMRi Q5R7E3. Positions 1-223.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5R7E3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100173339.
    KEGGi pon:100173339.

    Organism-specific databases

    CTDi 3162.

    Phylogenomic databases

    HOGENOMi HOG000233221.
    HOVERGENi HBG005982.
    InParanoidi Q5R7E3.
    KOi K00510.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view ]
    PANTHERi PTHR10720. PTHR10720. 1 hit.
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000343. Haem_Oase. 1 hit.
    PRINTSi PR00088. HAEMOXYGNASE.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiHMOX1_PONAB
    AccessioniPrimary (citable) accession number: Q5R7E3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3