Reviewed, UniProtKB/Swiss-Prot Q5R7E3 (HMOX1_PONAB)

Names and origin

Protein names

Recommended name:
    Heme oxygenase 1
      Short name=HO-1
    EC=1.14.99.3

Gene names

Name:

HMOX1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed By similarity.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Microsome By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the heme oxygenase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Heme oxygenase 1		PRO_0000317707
Sites
	Metal binding	25	1	Iron (heme axial ligand)
Amino acid modifications
	Modified residue	229	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R7E3-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 10400CCCCA98F7F3	FASTA	288	32,712
	10 20 30 40 50 60 MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTREGFKLV MASLYHIYVA 70 80 90 100 110 120 LEEEIEHNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE 130 140 150 160 170 180 VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALGLPSS GEGLAFFTFP NIASATKFKQ 190 200 210 220 230 240 LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA 250 260 270 280 SNKAQDSAPV ETPRGKTPLN THSQAPLLRW VLTLSFLVAT VAVGLYAM

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860175 mRNA. Translation: CAH92317.1.
RefSeq	NP_001126358.1.
UniGene	Pab.18812
3D structure databases
SMR	Q5R7E3. Positions 1-223.
ModBase	Search...
Genome annotation databases
GeneID	100173339.
Phylogenomic databases
HOVERGEN	Q5R7E3.
Enzyme and pathway databases
BRENDA	1.14.99.3. 269192.
Family and domain databases
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PANTHER	PTHR10720. Haem_Oase. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMOX1_PONAB

Accession

Primary (citable) accession number: Q5R7E3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 21, 2004
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)