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Q5R7C9 (AK1C3_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldo-keto reductase family 1 member C3 homolog

EC=1.-.-.-
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 5
Short name=17-beta-HSD 5
3-alpha-hydroxysteroid dehydrogenase type 2
Short name=3-alpha-HSD type 2
EC=1.1.1.213
Indanol dehydrogenase
EC=1.1.1.112
Prostaglandin F synthase
Short name=PGFS
EC=1.1.1.188
Testosterone 17-beta-dehydrogenase 5
EC=1.1.1.239
EC=1.1.1.64
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC=1.3.1.20
Gene names
Name:AKR1C3
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone By similarity.

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

A 3-alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H.

(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.

Testosterone + NAD+ = androstenedione + NADH.

Testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH.

Indan-1-ol + NAD(P)+ = indanone + NAD(P)H.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to cadmium ion

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to calcium ion

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to corticosteroid stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to jasmonic acid stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to prostaglandin stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to reactive oxygen species

Inferred from sequence or structural similarity. Source: UniProtKB

daunorubicin metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

farnesol catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of retinoic acid biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase B signaling cascade

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of reactive oxygen species metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

progesterone metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

prostaglandin metabolic process

Inferred from electronic annotation. Source: GOC

protein import into nucleus, translocation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of retinoic acid receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of testosterone biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

retinal metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

testosterone biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_function15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

Inferred from sequence or structural similarity. Source: UniProtKB

alditol:NADP+ 1-oxidoreductase activity

Inferred from sequence or structural similarity. Source: UniProtKB

androsterone dehydrogenase (A-specific) activity

Inferred from electronic annotation. Source: EC

androsterone dehydrogenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

delta4-3-oxosteroid 5beta-reductase activity

Inferred from sequence or structural similarity. Source: UniProtKB

dihydrotestosterone 17-beta-dehydrogenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

geranylgeranyl reductase activity

Inferred from sequence or structural similarity. Source: UniProtKB

indanol dehydrogenase activity

Inferred from electronic annotation. Source: EC

ketoreductase activity

Inferred from sequence or structural similarity. Source: UniProtKB

ketosteroid monooxygenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

Inferred from sequence or structural similarity. Source: UniProtKB

phenanthrene 9,10-monooxygenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

prostaglandin D2 11-ketoreductase activity

Inferred from electronic annotation. Source: EC

prostaglandin F receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

prostaglandin-F synthase activity

Inferred from electronic annotation. Source: EC

retinal dehydrogenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

retinol dehydrogenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

testosterone 17-beta-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

testosterone dehydrogenase (NAD+) activity

Inferred from electronic annotation. Source: EC

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Aldo-keto reductase family 1 member C3 homolog
PRO_0000124639

Regions

Nucleotide binding13 – 2210NADP Potential
Nucleotide binding217 – 28064NADP By similarity

Sites

Active site551Proton donor By similarity
Binding site1171Substrate By similarity
Site541Important for substrate specificity By similarity
Site841Lowers pKa of active site Tyr By similarity
Site2271Involved in ligand recognition and product release By similarity
Site3061Involved in ligand recognition and product release By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R7C9 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: DCAD6ECA97C204AB

FASTA32336,848
        10         20         30         40         50         60 
MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ 

        70         80         90        100        110        120 
VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM 

       130        140        150        160        170        180 
SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEECKDAGLA KSIGVSNFNR RQLEMILNKP 

       190        200        210        220        230        240 
GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV 

       250        260        270        280        290        300 
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN VQVFEFQLTA EDMRAIDGLN 

       310        320 
RNLHYFNSDS LASHPNYPYS DEY 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860189 mRNA. Translation: CAH92331.1.
RefSeqNP_001127540.1. NM_001134068.1.
UniGenePab.18808.

3D structure databases

ProteinModelPortalQ5R7C9.
SMRQ5R7C9. Positions 6-321.
ModBaseSearch...

Proteomic databases

PRIDEQ5R7C9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174617.
KEGGpon:100174617.

Organism-specific databases

CTD8644.

Phylogenomic databases

HOVERGENHBG000020.
InParanoidQ5R7C9.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. Aldo/ket_red. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAK1C3_PONAB
AccessionPrimary (citable) accession number: Q5R7C9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 21, 2004
Last modified: April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families