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Reviewed, UniProtKB/Swiss-Prot Q5R7C9 (AK1C3_PONAB)

Last modified January 19, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aldo-keto reductase family 1 member C3 homolog
    EC=1.-.-.-
Alternative name(s):
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    EC=1.3.1.20
    3-alpha-hydroxysteroid dehydrogenase type 2
      Short name=3-alpha-HSD type 2
    EC=1.1.1.213
    Testosterone 17-beta-dehydrogenase 5
    EC=1.1.1.63
    EC=1.1.1.64
    17-beta-hydroxysteroid dehydrogenase type 5
      Short name=17-beta-HSD 5
    Prostaglandin F synthase
      Short name=PGFS
    EC=1.1.1.188
    Indanol dehydrogenase
    EC=1.1.1.112
Gene names
Name: AKR1C3
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone By similarity.

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

Androsterone + NAD(P)+ = 5-alpha-androstane-3,17-dione + NAD(P)H.

(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.

Testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.

Testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH.

Indan-1-ol + NAD(P)+ = indanone + NAD(P)H.

Sequence similarities

Belongs to the aldo/keto reductase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Aldo-keto reductase family 1 member C3 homolog
PRO_0000124639

Regions

Nucleotide binding13 – 2210NADP Potential
Nucleotide binding217 – 28064NADP By similarity

Sites

Active site551Proton donor By similarity
Binding site1171Substrate By similarity
Site541Important for substrate specificity By similarity
Site841Lowers pKa of active site Tyr By similarity
Site2271Involved in ligand recognition and product release By similarity
Site3061Involved in ligand recognition and product release By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5R7C9-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: DCAD6ECA97C204AB

FASTA32336,848
        10         20         30         40         50         60 
MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ 

        70         80         90        100        110        120 
VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM 

       130        140        150        160        170        180 
SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEECKDAGLA KSIGVSNFNR RQLEMILNKP 

       190        200        210        220        230        240 
GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV 

       250        260        270        280        290        300 
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN VQVFEFQLTA EDMRAIDGLN 

       310        320 
RNLHYFNSDS LASHPNYPYS DEY

« Hide

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR860189 mRNA. Translation: CAH92331.1.
RefSeqNP_001127540.1.
UniGenePab.18808

3D structure databases

SMRQ5R7C9. Positions 6-321.
ModBaseSearch...

Genome annotation databases

GeneID100174617.

Organism-specific databases

CTD100174617.

Phylogenomic databases

HOVERGENQ5R7C9.
InParanoidQ5R7C9.

Enzyme and pathway databases

BRENDA1.1.1.188. 269192.
1.1.1.213. 269192.
1.1.1.63. 269192.
1.1.1.64. 269192.
1.3.1.20. 269192.

Family and domain databases

InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_sg.
[Graphical view]
Gene3DG3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHERPTHR11732. Aldo/ket_red. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSPR00069. ALDKETRDTASE.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAK1C3_PONAB
AccessionPrimary (citable) accession number: Q5R7C9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 21, 2004
Last modified: January 19, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents