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Q5R7C3 (HNMT_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histamine N-methyltransferase

Short name=HMT
EC=2.1.1.8
Gene names
Name:HNMT
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activity

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistamine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Histamine N-methyltransferase
PRO_0000084023

Sites

Binding site281Substrate By similarity
Binding site601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site891S-adenosyl-L-methionine By similarity
Binding site941S-adenosyl-L-methionine By similarity
Binding site1201S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R7C3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 71EAC321E850C7D7

FASTA29233,222
        10         20         30         40         50         60 
MVSSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIARIGDT KSEIKILSIG 

        70         80         90        100        110        120 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKG PVAKTSNLEN VKFAWHKETS 

       130        140        150        160        170        180 
SEYQSRILEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD 

       190        200        210        220        230        240 
KLWKKYGSRF PQNDLCQYVT SDDLTQMLDN LGLKYECYDL FSTMDISDCF IDGNENGDLL 

       250        260        270        280        290 
WDFLTETCNF NATAPPDLKA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860195 mRNA. Translation: CAH92337.1.
RefSeqNP_001127541.1. NM_001134069.1.

3D structure databases

ProteinModelPortalQ5R7C3.
SMRQ5R7C3. Positions 5-292.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174618.
KEGGpon:100174618.

Organism-specific databases

CTD3176.

Phylogenomic databases

HOVERGENHBG051914.
InParanoidQ5R7C3.
KOK00546.

Family and domain databases

InterProIPR016673. Histamine_N-methyltransferase.
[Graphical view]
PANTHERPTHR32330:SF0. PTHR32330:SF0. 1 hit.
PIRSFPIRSF016616. HHMT. 1 hit.
PROSITEPS51597. SAM_HNMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHNMT_PONAB
AccessionPrimary (citable) accession number: Q5R7C3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 21, 2004
Last modified: November 13, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families