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Protein

Ribonuclease P protein subunit p29

Gene

POP4

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p29 (EC:3.1.26.5)
Gene namesi
Name:POP4
Synonyms:RPP29
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001284201 – 220Ribonuclease P protein subunit p29Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5R7B0.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000010980.

Structurei

3D structure databases

ProteinModelPortaliQ5R7B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 74Poly-Lys10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4046. Eukaryota.
ENOG4111FUV. LUCA.
GeneTreeiENSGT00390000010067.
HOVERGENiHBG002676.
InParanoidiQ5R7B0.
KOiK03538.
OMAiPKSECVF.
OrthoDBiEOG091G0O40.
TreeFamiTF313883.

Family and domain databases

Gene3Di2.30.30.210. 1 hit.
InterProiView protein in InterPro
IPR002730. RNase_P/MRP_p29.
IPR016848. RNase_P/MRP_p29-subunit.
IPR036980. RNase_P/MRP_p29_sf.
IPR023534. Rof/RNase_P-like.
PfamiView protein in Pfam
PF01868. UPF0086. 1 hit.
PIRSFiPIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMARTiView protein in SMART
SM00538. POP4. 1 hit.
SUPFAMiSSF101744. SSF101744. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R7B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVIYHALS QKEANDSDVQ PSGAQRAEAF VRAFLKRSTP RMSPQAREDQ
60 70 80 90 100
LQRKAVVLEY FTRHKRKEKK KKAKGLSARQ RRELRLFDIK PEQQRYSLFL
110 120 130 140 150
PLHELWKQYI RDLCNGLKPD TQPQMIQAKL LKADLHGAII SVTKSKCPSY
160 170 180 190 200
VGITGILLQE TKHIFKIITK EDRLKVIPKL NCVFTVEIDG FISYIYGSKF
210 220
QLRSSERSAK KFKAKGTIDL
Length:220
Mass (Da):25,464
Last modified:December 21, 2004 - v1
Checksum:iCFD1861563DD648F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860208 mRNA. Translation: CAH92350.1.
RefSeqiNP_001126383.1. NM_001132911.1.
UniGeneiPab.9084.

Genome annotation databases

EnsembliENSPPYT00000011409; ENSPPYP00000010980; ENSPPYG00000009805.
GeneIDi100173364.
KEGGipon:100173364.

Similar proteinsi

Entry informationi

Entry nameiRPP29_PONAB
AccessioniPrimary (citable) accession number: Q5R7B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families