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Q5R7B0

- RPP29_PONAB

UniProt

Q5R7B0 - RPP29_PONAB

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Protein
Ribonuclease P protein subunit p29
Gene
POP4, RPP29
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P By similarity.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. ribonuclease P activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. mRNA cleavage Source: InterPro
  2. rRNA processing Source: InterPro
  3. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p29 (EC:3.1.26.5)
Gene namesi
Name:POP4
Synonyms:RPP29
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 19

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolar ribonuclease P complex Source: InterPro
  2. ribonuclease MRP complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Ribonuclease P protein subunit p29
PRO_0000128420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5R7B0.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R7B0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 7410Poly-Lys

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000010067.
HOVERGENiHBG002676.
InParanoidiQ5R7B0.
KOiK03538.
OMAiMSQQACE.
OrthoDBiEOG786H4B.
TreeFamiTF313883.

Family and domain databases

Gene3Di2.30.30.210. 1 hit.
InterProiIPR002730. RNase_P/MRP_p29.
IPR016848. RNase_P/MRP_p29-subunit.
IPR023534. Rof/RNase_P-like.
[Graphical view]
PfamiPF01868. UPF0086. 1 hit.
[Graphical view]
PIRSFiPIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMARTiSM00538. POP4. 1 hit.
[Graphical view]
SUPFAMiSSF101744. SSF101744. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R7B0-1 [UniParc]FASTAAdd to Basket

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MKSVIYHALS QKEANDSDVQ PSGAQRAEAF VRAFLKRSTP RMSPQAREDQ    50
LQRKAVVLEY FTRHKRKEKK KKAKGLSARQ RRELRLFDIK PEQQRYSLFL 100
PLHELWKQYI RDLCNGLKPD TQPQMIQAKL LKADLHGAII SVTKSKCPSY 150
VGITGILLQE TKHIFKIITK EDRLKVIPKL NCVFTVEIDG FISYIYGSKF 200
QLRSSERSAK KFKAKGTIDL 220
Length:220
Mass (Da):25,464
Last modified:December 21, 2004 - v1
Checksum:iCFD1861563DD648F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860208 mRNA. Translation: CAH92350.1.
RefSeqiNP_001126383.1. NM_001132911.1.
UniGeneiPab.9084.

Genome annotation databases

EnsembliENSPPYT00000011409; ENSPPYP00000010980; ENSPPYG00000009805.
GeneIDi100173364.
KEGGipon:100173364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860208 mRNA. Translation: CAH92350.1 .
RefSeqi NP_001126383.1. NM_001132911.1.
UniGenei Pab.9084.

3D structure databases

ProteinModelPortali Q5R7B0.
ModBasei Search...

Proteomic databases

PRIDEi Q5R7B0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000011409 ; ENSPPYP00000010980 ; ENSPPYG00000009805 .
GeneIDi 100173364.
KEGGi pon:100173364.

Organism-specific databases

CTDi 10775.

Phylogenomic databases

GeneTreei ENSGT00390000010067.
HOVERGENi HBG002676.
InParanoidi Q5R7B0.
KOi K03538.
OMAi MSQQACE.
OrthoDBi EOG786H4B.
TreeFami TF313883.

Family and domain databases

Gene3Di 2.30.30.210. 1 hit.
InterProi IPR002730. RNase_P/MRP_p29.
IPR016848. RNase_P/MRP_p29-subunit.
IPR023534. Rof/RNase_P-like.
[Graphical view ]
Pfami PF01868. UPF0086. 1 hit.
[Graphical view ]
PIRSFi PIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMARTi SM00538. POP4. 1 hit.
[Graphical view ]
SUPFAMi SSF101744. SSF101744. 1 hit.
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiRPP29_PONAB
AccessioniPrimary (citable) accession number: Q5R7B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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