Q5R7B0 (RPP29_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p29
EC=3.1.26.5

Gene names

Name:	POP4
Synonyms:	RPP29

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5 By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA cleavage Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolar ribonuclease P complex Inferred from electronic annotation. Source: InterPro ribonuclease MRP complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Ribonuclease P protein subunit p29		PRO_0000128420
Regions
	Compositional bias	65 – 74	10	Poly-Lys
Amino acid modifications
	Modified residue	10	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R7B0 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: CFD1861563DD648F	FASTA	220	25,464
	10 20 30 40 50 60 MKSVIYHALS QKEANDSDVQ PSGAQRAEAF VRAFLKRSTP RMSPQAREDQ LQRKAVVLEY 70 80 90 100 110 120 FTRHKRKEKK KKAKGLSARQ RRELRLFDIK PEQQRYSLFL PLHELWKQYI RDLCNGLKPD 130 140 150 160 170 180 TQPQMIQAKL LKADLHGAII SVTKSKCPSY VGITGILLQE TKHIFKIITK EDRLKVIPKL 190 200 210 220 NCVFTVEIDG FISYIYGSKF QLRSSERSAK KFKAKGTIDL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860208 mRNA. Translation: CAH92350.1.
RefSeq	NP_001126383.1. NM_001132911.1.
UniGene	Pab.9084.
3D structure databases
ProteinModelPortal	Q5R7B0.
ModBase	Search...
Proteomic databases
PRIDE	Q5R7B0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000011409; ENSPPYP00000010980; ENSPPYG00000009805.
GeneID	100173364.
KEGG	pon:100173364.
Organism-specific databases
CTD	10775.
Phylogenomic databases
GeneTree	ENSGT00390000010067.
HOVERGEN	HBG002676.
InParanoid	Q5R7B0.
KO	K03538.
OMA	RSKCPSY.
OrthoDB	EOG4TXBT7.
Family and domain databases
Gene3D	2.30.30.210. 1 hit.
InterPro	IPR002730. RNase_P/MRP_p29. IPR016848. RNase_P/MRP_p29-subunit. IPR023534. Rof/RNase_P-like. [Graphical view]
Pfam	PF01868. UPF0086. 1 hit. [Graphical view]
PIRSF	PIRSF027081. RNase_P/MRP_p29_subunit. 1 hit.
SMART	SM00538. POP4. 1 hit. [Graphical view]
SUPFAM	SSF101744. RNase_P_Rpp29. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPP29_PONAB

Accession

Primary (citable) accession number: Q5R7B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program