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Q5R7A9 (LYAG_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysosomal alpha-glucosidase
EC=3.2.1.20
Alternative name(s):
Acid maltase
Gene names
Name:GAA
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length952 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for the degradation of glygogen to glucose in lysosomes By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Subcellular location

Lysosome By similarity. Lysosome membrane By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 31 family.

Contains 1 P-type (trefoil) domain.

Ontologies

Keywords
   Cellular componentLysosome
Membrane
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

maltose alpha-glucosidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Propeptide28 – 6942 By similarity
PRO_0000260440
Chain70 – 952883Lysosomal alpha-glucosidase
PRO_0000260441

Regions

Domain80 – 13152P-type

Sites

Active site5181Nucleophile By similarity
Active site5211 By similarity

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential
Glycosylation6521N-linked (GlcNAc...) Potential
Glycosylation8821N-linked (GlcNAc...) Potential
Glycosylation9251N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5R7A9 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 4AEC592583525C16

FASTA952105,531
        10         20         30         40         50         60 
MRVRHPPCSR RLLAICALVS LATAALLGHI LLHDFLLVPR ELSGSSPVLE ETHPAHQQGA 

        70         80         90        100        110        120 
SRPGPRDAQA HLGRPRAVPT QCDVPPNSRF DCAPDKAITR EQCDARGCCY IPAKQGLRGA 

       130        140        150        160        170        180 
QMGQPWCFFP PSYPSYKLEN LSSSEMGYTA TLTRTTPTFF PKDILTLRLD VMMETENRLH 

       190        200        210        220        230        240 
FTIKDPANRR YEVPLETPRV HSRAPSPLYS VEFSEEPFGV IVRRQLDGRV LLNTTVAPLF 

       250        260        270        280        290        300 
FADQFLQLST SLPSQYITGL AEHLSPLMLS TSWTRVTLWN RDLAPTPGAN LYGSHPFYLA 

       310        320        330        340        350        360 
LEDGGSAHGV FLLNSNAMDV VLQPSPALSW RSTGGILDVY IFLGPEPKSV VRQYLDVVGY 

       370        380        390        400        410        420 
PFMPPYWGLG FHLCRWGYSS TAITSQVVEN MTRAHFPLDV QWNDLDYMDA RRDFTFNKDG 

       430        440        450        460        470        480 
FRDFPAMVRE LHQGGRRYMM IVDPAISSSG PAGSYRPYDE GLRRGVFITN ETSQPLIGKV 

       490        500        510        520        530        540 
WPGSTAFPDF TNPAALAWWE DMVAEFHDQV PFDGMWIDMN EPSNFIRGSE DGCPDNELEN 

       550        560        570        580        590        600 
PPYVPGVVGG TLQAATICAS SHQFLSTHYN LHNLYGLTEA IASHRALVKA RGTRPFVISR 

       610        620        630        640        650        660 
STFAGHGRYA GHWTGDVWSS WEQLASSVPE ILQFNLLGVP LVGADVCGFL GNTSEELCVR 

       670        680        690        700        710        720 
WTQLGAFYPF MRNHNGLLNL PQEPYSFSEP AQQAMRKALT LRYALLPHLY TLFHQAHVAG 

       730        740        750        760        770        780 
ETVARPLFLE FPKDSSTWTV DHQLLWGEAL LITPVLQAGK AEVTGYFPLG IWYDLQTVPI 

       790        800        810        820        830        840 
EALGSLPPPP AAPREPAIHS EGQWVTLPAP LDTINVHLRA GYIIPLQGPG LTTTESRQQP 

       850        860        870        880        890        900 
MALAVALTKG GEARGELFWD DGESLEVLER GAYTQVLFLA RNNTIVNELV HVTSEGAGLQ 

       910        920        930        940        950 
LQKVTVLGVA TTPQQVLSNG VPVSNFTYSP DTKVLDIPVS LLMAEQFLIS WS

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR860209 mRNA. Translation: CAH92351.1.
RefSeqNP_001126384.1. NM_001132912.2.
UniGenePab.6021.

3D structure databases

ProteinModelPortalQ5R7A9.
ModBaseSearch...

Protein family/group databases

CAZyGH31. Glycoside Hydrolase Family 31.

Proteomic databases

PRIDEQ5R7A9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173365.
KEGGpon:100173365.

Organism-specific databases

CTD2548.

Phylogenomic databases

HOVERGENHBG006297.
InParanoidQ5R7A9.
KOK12316.

Family and domain databases

Gene3D4.10.110.10. 1 hit.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
[Graphical view]
PANTHERPTHR22762. PTHR22762. 1 hit.
PfamPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
PF00088. Trefoil. 1 hit.
[Graphical view]
SMARTSM00018. PD. 1 hit.
[Graphical view]
SUPFAMSSF74650. Gal_mut_like. 1 hit.
SSF51445. Glyco_hydro_cat. 1 hit.
PROSITEPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYAG_PONAB
AccessionPrimary (citable) accession number: Q5R7A9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 21, 2004
Last modified: March 6, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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