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Q5R7A9

- LYAG_PONAB

UniProt

Q5R7A9 - LYAG_PONAB

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Protein

Lysosomal alpha-glucosidase

Gene

GAA

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Essential for the degradation of glygogen to glucose in lysosomes.By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei518 – 5181NucleophilePROSITE-ProRule annotation
Active sitei521 – 5211By similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Acid maltase
Gene namesi
Name:GAA
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Lysosome By similarity. Lysosome membrane By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Propeptidei28 – 6942By similarityPRO_0000260440Add
BLAST
Chaini70 – 952883Lysosomal alpha-glucosidasePRO_0000260441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi925 – 9251N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5R7A9.

Structurei

3D structure databases

ProteinModelPortaliQ5R7A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 13152P-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated
Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006297.
InParanoidiQ5R7A9.
KOiK12316.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
PF00088. Trefoil. 1 hit.
[Graphical view]
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF57492. SSF57492. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R7A9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVRHPPCSR RLLAICALVS LATAALLGHI LLHDFLLVPR ELSGSSPVLE
60 70 80 90 100
ETHPAHQQGA SRPGPRDAQA HLGRPRAVPT QCDVPPNSRF DCAPDKAITR
110 120 130 140 150
EQCDARGCCY IPAKQGLRGA QMGQPWCFFP PSYPSYKLEN LSSSEMGYTA
160 170 180 190 200
TLTRTTPTFF PKDILTLRLD VMMETENRLH FTIKDPANRR YEVPLETPRV
210 220 230 240 250
HSRAPSPLYS VEFSEEPFGV IVRRQLDGRV LLNTTVAPLF FADQFLQLST
260 270 280 290 300
SLPSQYITGL AEHLSPLMLS TSWTRVTLWN RDLAPTPGAN LYGSHPFYLA
310 320 330 340 350
LEDGGSAHGV FLLNSNAMDV VLQPSPALSW RSTGGILDVY IFLGPEPKSV
360 370 380 390 400
VRQYLDVVGY PFMPPYWGLG FHLCRWGYSS TAITSQVVEN MTRAHFPLDV
410 420 430 440 450
QWNDLDYMDA RRDFTFNKDG FRDFPAMVRE LHQGGRRYMM IVDPAISSSG
460 470 480 490 500
PAGSYRPYDE GLRRGVFITN ETSQPLIGKV WPGSTAFPDF TNPAALAWWE
510 520 530 540 550
DMVAEFHDQV PFDGMWIDMN EPSNFIRGSE DGCPDNELEN PPYVPGVVGG
560 570 580 590 600
TLQAATICAS SHQFLSTHYN LHNLYGLTEA IASHRALVKA RGTRPFVISR
610 620 630 640 650
STFAGHGRYA GHWTGDVWSS WEQLASSVPE ILQFNLLGVP LVGADVCGFL
660 670 680 690 700
GNTSEELCVR WTQLGAFYPF MRNHNGLLNL PQEPYSFSEP AQQAMRKALT
710 720 730 740 750
LRYALLPHLY TLFHQAHVAG ETVARPLFLE FPKDSSTWTV DHQLLWGEAL
760 770 780 790 800
LITPVLQAGK AEVTGYFPLG IWYDLQTVPI EALGSLPPPP AAPREPAIHS
810 820 830 840 850
EGQWVTLPAP LDTINVHLRA GYIIPLQGPG LTTTESRQQP MALAVALTKG
860 870 880 890 900
GEARGELFWD DGESLEVLER GAYTQVLFLA RNNTIVNELV HVTSEGAGLQ
910 920 930 940 950
LQKVTVLGVA TTPQQVLSNG VPVSNFTYSP DTKVLDIPVS LLMAEQFLIS

WS
Length:952
Mass (Da):105,531
Last modified:December 21, 2004 - v1
Checksum:i4AEC592583525C16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860209 mRNA. Translation: CAH92351.1.
RefSeqiNP_001126384.1. NM_001132912.2.
UniGeneiPab.6021.

Genome annotation databases

GeneIDi100173365.
KEGGipon:100173365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860209 mRNA. Translation: CAH92351.1 .
RefSeqi NP_001126384.1. NM_001132912.2.
UniGenei Pab.6021.

3D structure databases

ProteinModelPortali Q5R7A9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH31. Glycoside Hydrolase Family 31.

Proteomic databases

PRIDEi Q5R7A9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100173365.
KEGGi pon:100173365.

Organism-specific databases

CTDi 2548.

Phylogenomic databases

HOVERGENi HBG006297.
InParanoidi Q5R7A9.
KOi K12316.

Family and domain databases

Gene3Di 4.10.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
[Graphical view ]
Pfami PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
PF00088. Trefoil. 1 hit.
[Graphical view ]
SMARTi SM00018. PD. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF57492. SSF57492. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiLYAG_PONAB
AccessioniPrimary (citable) accession number: Q5R7A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3