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Q5R7A9

- LYAG_PONAB

UniProt

Q5R7A9 - LYAG_PONAB

Protein

Lysosomal alpha-glucosidase

Gene

GAA

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Essential for the degradation of glygogen to glucose in lysosomes.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei518 – 5181NucleophilePROSITE-ProRule annotation
    Active sitei521 – 5211By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH31. Glycoside Hydrolase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal alpha-glucosidase (EC:3.2.1.20)
    Alternative name(s):
    Acid maltase
    Gene namesi
    Name:GAA
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Lysosome By similarity. Lysosome membrane By similarity

    GO - Cellular componenti

    1. lysosomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Propeptidei28 – 6942By similarityPRO_0000260440Add
    BLAST
    Chaini70 – 952883Lysosomal alpha-glucosidasePRO_0000260441Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi925 – 9251N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5R7A9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R7A9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 13152P-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 31 family.Curated
    Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006297.
    InParanoidiQ5R7A9.
    KOiK12316.

    Family and domain databases

    Gene3Di4.10.110.10. 1 hit.
    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR000519. P_trefoil.
    IPR017957. P_trefoil_CS.
    [Graphical view]
    PfamiPF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    PF00088. Trefoil. 1 hit.
    [Graphical view]
    SMARTiSM00018. PD. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.
    SSF57492. SSF57492. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
    PS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R7A9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVRHPPCSR RLLAICALVS LATAALLGHI LLHDFLLVPR ELSGSSPVLE    50
    ETHPAHQQGA SRPGPRDAQA HLGRPRAVPT QCDVPPNSRF DCAPDKAITR 100
    EQCDARGCCY IPAKQGLRGA QMGQPWCFFP PSYPSYKLEN LSSSEMGYTA 150
    TLTRTTPTFF PKDILTLRLD VMMETENRLH FTIKDPANRR YEVPLETPRV 200
    HSRAPSPLYS VEFSEEPFGV IVRRQLDGRV LLNTTVAPLF FADQFLQLST 250
    SLPSQYITGL AEHLSPLMLS TSWTRVTLWN RDLAPTPGAN LYGSHPFYLA 300
    LEDGGSAHGV FLLNSNAMDV VLQPSPALSW RSTGGILDVY IFLGPEPKSV 350
    VRQYLDVVGY PFMPPYWGLG FHLCRWGYSS TAITSQVVEN MTRAHFPLDV 400
    QWNDLDYMDA RRDFTFNKDG FRDFPAMVRE LHQGGRRYMM IVDPAISSSG 450
    PAGSYRPYDE GLRRGVFITN ETSQPLIGKV WPGSTAFPDF TNPAALAWWE 500
    DMVAEFHDQV PFDGMWIDMN EPSNFIRGSE DGCPDNELEN PPYVPGVVGG 550
    TLQAATICAS SHQFLSTHYN LHNLYGLTEA IASHRALVKA RGTRPFVISR 600
    STFAGHGRYA GHWTGDVWSS WEQLASSVPE ILQFNLLGVP LVGADVCGFL 650
    GNTSEELCVR WTQLGAFYPF MRNHNGLLNL PQEPYSFSEP AQQAMRKALT 700
    LRYALLPHLY TLFHQAHVAG ETVARPLFLE FPKDSSTWTV DHQLLWGEAL 750
    LITPVLQAGK AEVTGYFPLG IWYDLQTVPI EALGSLPPPP AAPREPAIHS 800
    EGQWVTLPAP LDTINVHLRA GYIIPLQGPG LTTTESRQQP MALAVALTKG 850
    GEARGELFWD DGESLEVLER GAYTQVLFLA RNNTIVNELV HVTSEGAGLQ 900
    LQKVTVLGVA TTPQQVLSNG VPVSNFTYSP DTKVLDIPVS LLMAEQFLIS 950
    WS 952
    Length:952
    Mass (Da):105,531
    Last modified:December 21, 2004 - v1
    Checksum:i4AEC592583525C16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860209 mRNA. Translation: CAH92351.1.
    RefSeqiNP_001126384.1. NM_001132912.2.
    UniGeneiPab.6021.

    Genome annotation databases

    GeneIDi100173365.
    KEGGipon:100173365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860209 mRNA. Translation: CAH92351.1 .
    RefSeqi NP_001126384.1. NM_001132912.2.
    UniGenei Pab.6021.

    3D structure databases

    ProteinModelPortali Q5R7A9.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH31. Glycoside Hydrolase Family 31.

    Proteomic databases

    PRIDEi Q5R7A9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100173365.
    KEGGi pon:100173365.

    Organism-specific databases

    CTDi 2548.

    Phylogenomic databases

    HOVERGENi HBG006297.
    InParanoidi Q5R7A9.
    KOi K12316.

    Family and domain databases

    Gene3Di 4.10.110.10. 1 hit.
    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR000519. P_trefoil.
    IPR017957. P_trefoil_CS.
    [Graphical view ]
    Pfami PF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    PF00088. Trefoil. 1 hit.
    [Graphical view ]
    SMARTi SM00018. PD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    SSF57492. SSF57492. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
    PS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiLYAG_PONAB
    AccessioniPrimary (citable) accession number: Q5R7A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3