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Protein

Chitobiosyldiphosphodolichol beta-mannosyltransferase

Gene

ALG1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man5 intermediate on the cytoplasmic surface of the ER (By similarity).By similarity

Catalytic activityi

GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT33. Glycosyltransferase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC:2.4.1.142)
Alternative name(s):
Asparagine-linked glycosylation protein 1 homolog
Beta-1,4-mannosyltransferase
GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase
Gene namesi
Name:ALG1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence analysis
Transmembranei3 – 2321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini24 – 464441LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Chitobiosyldiphosphodolichol beta-mannosyltransferasePRO_0000080251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5R7A2.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000008002.

Structurei

3D structure databases

ProteinModelPortaliQ5R7A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2941. Eukaryota.
COG0438. LUCA.
GeneTreeiENSGT00390000008647.
HOVERGENiHBG055036.
InParanoidiQ5R7A2.
KOiK03842.
OMAiPKKRNAC.
OrthoDBiEOG70W3DB.
TreeFamiTF314121.

Family and domain databases

InterProiIPR026051. ALG1-like.
IPR001296. Glyco_trans_1.
[Graphical view]
PANTHERiPTHR13036. PTHR13036. 1 hit.
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R7A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASCLVLLA LCLLLPLLLL GGWKRWRRGR TARHVVAVVL GDVGRSPRMQ
60 70 80 90 100
YHALSLAMHG FSVTLLGFCN SKPHDELLQN NRIQIVGLTE LQSLAVGPRV
110 120 130 140 150
FQYGVKVVFQ AMYLLWKLMW REPGAYIFLQ NPPGLPSIAV CWFVGCLCGS
160 170 180 190 200
KLVIDWHNYG YSIMGLVHGP NHPLVLLAKW YERFFGRLSH LNLCVTNAMR
210 220 230 240 250
EDLAENWHIR AVTVYDKPAS FFKETPLDLQ HRLFMKLGGT HSPFRARSEP
260 270 280 290 300
EDPATERSAF TERDAGSGLV TRLHERPALL VSSTSWTEDE DFSILLAALE
310 320 330 340 350
KFEQLTLDGH SLPSLVCVIT GKGPLREYYS HLIHQKHFQH IQVCTPWLEA
360 370 380 390 400
EDYPLLLGSA DLGVCLHTSS SGLDLPMKVV DMFGCHLPVC AVNFKCLHEL
410 420 430 440 450
VKHEENGLVF EDSEELAAQL QMLFSNFPDP AGKLNQFRKN LRESQQLRWD
460
ESWVQTVLPL VMDT
Length:464
Mass (Da):52,505
Last modified:December 21, 2004 - v1
Checksum:i12CCBEC1ACA1BCA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860216 mRNA. Translation: CAH92358.1.
RefSeqiNP_001126389.1. NM_001132917.2.
UniGeneiPab.9117.

Genome annotation databases

EnsembliENSPPYT00000008333; ENSPPYP00000008002; ENSPPYG00000007077.
GeneIDi100173370.
KEGGipon:100173370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860216 mRNA. Translation: CAH92358.1.
RefSeqiNP_001126389.1. NM_001132917.2.
UniGeneiPab.9117.

3D structure databases

ProteinModelPortaliQ5R7A2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000008002.

Protein family/group databases

CAZyiGT33. Glycosyltransferase Family 33.

Proteomic databases

PRIDEiQ5R7A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000008333; ENSPPYP00000008002; ENSPPYG00000007077.
GeneIDi100173370.
KEGGipon:100173370.

Organism-specific databases

CTDi56052.

Phylogenomic databases

eggNOGiKOG2941. Eukaryota.
COG0438. LUCA.
GeneTreeiENSGT00390000008647.
HOVERGENiHBG055036.
InParanoidiQ5R7A2.
KOiK03842.
OMAiPKKRNAC.
OrthoDBiEOG70W3DB.
TreeFamiTF314121.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR026051. ALG1-like.
IPR001296. Glyco_trans_1.
[Graphical view]
PANTHERiPTHR13036. PTHR13036. 1 hit.
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiALG1_PONAB
AccessioniPrimary (citable) accession number: Q5R7A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.