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Protein

Acyl-CoA dehydrogenase family member 11

Gene

ACAD11

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.By similarity

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei515 – 5151Substrate; via carbonyl oxygenBy similarity
Binding sitei541 – 5411FADBy similarity
Binding sitei658 – 6581FADBy similarity
Binding sitei658 – 6581FAD; shared with dimeric partnerBy similarity
Binding sitei728 – 7281FADBy similarity
Binding sitei756 – 7561Substrate; via amide nitrogenBy similarity
Binding sitei759 – 7591FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi505 – 51511FADBy similarityAdd
BLAST
Nucleotide bindingi505 – 5084FADBy similarity
Nucleotide bindingi513 – 5153FADBy similarity
Nucleotide bindingi539 – 5413FADBy similarity
Nucleotide bindingi728 – 7325FAD; shared with dimeric partnerBy similarity
Nucleotide bindingi757 – 7593FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase family member 11 (EC:1.3.99.-)
Short name:
ACAD-11
Gene namesi
Name:ACAD11
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 781781Acyl-CoA dehydrogenase family member 11PRO_0000254147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei177 – 1771N6-acetyllysineBy similarity
Modified residuei325 – 3251PhosphotyrosineBy similarity
Modified residuei392 – 3921N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015783.

Structurei

3D structure databases

ProteinModelPortaliQ5R778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni630 – 6334Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
GeneTreeiENSGT00760000119007.
HOVERGENiHBG057142.
InParanoidiQ5R778.
KOiK11730.
OMAiDWELSTT.
OrthoDBiEOG7W9RT3.
TreeFamiTF333953.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPGATGESD LAEVLPQHKF DSKSLEAYLN QHLSGFGAER EATLTIAQYR
60 70 80 90 100
AGKSNPTFYL QKGFQTYVLR KKPPGSLLPK AHQIDREFKV QKALFSIGFP
110 120 130 140 150
VPKPILYCSD TSVIGTEFYI MEHVQGRIFR DLTIPGVSPA ERSALYVAIV
160 170 180 190 200
ETLAQLHSLN IQSLQLEGYG IGAGYCKRQV STWTKQYQAA AHQDIPAMQQ
210 220 230 240 250
LSEWLMKNLP DNDNEENLIH GDFRLDNIIF HPKECRVIAV LDWELSTIGH
260 270 280 290 300
PLSDLAHFSL FYFWPRTVPM INQGSYSEEN SGIPSMEELI SIYCRCRGIN
310 320 330 340 350
SSLPNWNFFL ALSYFKMAGI AQGVYSRYLL GNNSSEDSFL FANIVQPLAE
360 370 380 390 400
TGLQLSKRTF STVLPQIDTA GQLFVQTRKG QEVLIKVKHF MKQHILPAEK
410 420 430 440 450
EVTEFYVQNE NSVDKWGKPL VIDKLKEMAK AEGLWNLFLP AVSGLSQVDY
460 470 480 490 500
ALIAEETGKC FFAPDVFNCQ APDTGNMEIL HLYGSEEQKK QWLEPLLQGN
510 520 530 540 550
ITSCFCMTEP DVASSDATNI ECSIQREEDS YVINGKKWWS SGAGNPKCKI
560 570 580 590 600
AIVLGRTQNT SLSRHKQHSM ILVPMNTPGV EIIRPLSVFG YTDNFHGGHF
610 620 630 640 650
EIHFNQVRVP ATNLILGEGR GFEISQGRLG PGRIHHCMRT VGLAERALQI
660 670 680 690 700
MCERATQRIA FKKKLYAHEV VAHWIAESRI AIEKIRLLTL KAAHSMDTLG
710 720 730 740 750
SAGAKKEIAM IKVAAPRAVS KIVDWAIQVC GGAGVSQDYP LANMYAITRV
760 770 780
LRLADGPDEV HLSAIATMEL RDQAKRLTAK I
Length:781
Mass (Da):87,355
Last modified:October 31, 2006 - v2
Checksum:iCF99D673654FD3DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51A → T in CAH89526 (Ref. 1) Curated
Sequence conflicti137 – 1371V → A in CAH92382 (Ref. 1) Curated
Sequence conflicti723 – 7231V → I in CAH89526 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857227 mRNA. Translation: CAH89526.1.
CR860240 mRNA. Translation: CAH92382.1.
RefSeqiNP_001126403.1. NM_001132931.2.

Genome annotation databases

EnsembliENSPPYT00000016405; ENSPPYP00000015783; ENSPPYG00000014106.
GeneIDi100173386.
KEGGipon:100173386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857227 mRNA. Translation: CAH89526.1.
CR860240 mRNA. Translation: CAH92382.1.
RefSeqiNP_001126403.1. NM_001132931.2.

3D structure databases

ProteinModelPortaliQ5R778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000016405; ENSPPYP00000015783; ENSPPYG00000014106.
GeneIDi100173386.
KEGGipon:100173386.

Organism-specific databases

CTDi84129.

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
GeneTreeiENSGT00760000119007.
HOVERGENiHBG057142.
InParanoidiQ5R778.
KOiK11730.
OMAiDWELSTT.
OrthoDBiEOG7W9RT3.
TreeFamiTF333953.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiACD11_PONAB
AccessioniPrimary (citable) accession number: Q5R778
Secondary accession number(s): Q5RFD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: March 16, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.