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Protein

Acyl-CoA dehydrogenase family member 11

Gene

ACAD11

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.By similarity

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei515Substrate; via carbonyl oxygenBy similarity1
Binding sitei541FADBy similarity1
Binding sitei658FADBy similarity1
Binding sitei658FAD; shared with dimeric partnerBy similarity1
Binding sitei728FADBy similarity1
Binding sitei756Substrate; via amide nitrogenBy similarity1
Binding sitei759FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi505 – 515FADBy similarityAdd BLAST11
Nucleotide bindingi505 – 508FADBy similarity4
Nucleotide bindingi513 – 515FADBy similarity3
Nucleotide bindingi539 – 541FADBy similarity3
Nucleotide bindingi728 – 732FAD; shared with dimeric partnerBy similarity5
Nucleotide bindingi757 – 759FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase family member 11 (EC:1.3.99.-)
Short name:
ACAD-11
Gene namesi
Name:ACAD11
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541471 – 781Acyl-CoA dehydrogenase family member 11Add BLAST781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177N6-acetyllysineBy similarity1
Modified residuei325PhosphotyrosineBy similarity1
Modified residuei392N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015783.

Structurei

3D structure databases

ProteinModelPortaliQ5R778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni630 – 633Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
GeneTreeiENSGT00760000119007.
HOVERGENiHBG057142.
InParanoidiQ5R778.
KOiK11730.
OMAiKECRVIA.
OrthoDBiEOG091G03B8.
TreeFamiTF333953.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPGATGESD LAEVLPQHKF DSKSLEAYLN QHLSGFGAER EATLTIAQYR
60 70 80 90 100
AGKSNPTFYL QKGFQTYVLR KKPPGSLLPK AHQIDREFKV QKALFSIGFP
110 120 130 140 150
VPKPILYCSD TSVIGTEFYI MEHVQGRIFR DLTIPGVSPA ERSALYVAIV
160 170 180 190 200
ETLAQLHSLN IQSLQLEGYG IGAGYCKRQV STWTKQYQAA AHQDIPAMQQ
210 220 230 240 250
LSEWLMKNLP DNDNEENLIH GDFRLDNIIF HPKECRVIAV LDWELSTIGH
260 270 280 290 300
PLSDLAHFSL FYFWPRTVPM INQGSYSEEN SGIPSMEELI SIYCRCRGIN
310 320 330 340 350
SSLPNWNFFL ALSYFKMAGI AQGVYSRYLL GNNSSEDSFL FANIVQPLAE
360 370 380 390 400
TGLQLSKRTF STVLPQIDTA GQLFVQTRKG QEVLIKVKHF MKQHILPAEK
410 420 430 440 450
EVTEFYVQNE NSVDKWGKPL VIDKLKEMAK AEGLWNLFLP AVSGLSQVDY
460 470 480 490 500
ALIAEETGKC FFAPDVFNCQ APDTGNMEIL HLYGSEEQKK QWLEPLLQGN
510 520 530 540 550
ITSCFCMTEP DVASSDATNI ECSIQREEDS YVINGKKWWS SGAGNPKCKI
560 570 580 590 600
AIVLGRTQNT SLSRHKQHSM ILVPMNTPGV EIIRPLSVFG YTDNFHGGHF
610 620 630 640 650
EIHFNQVRVP ATNLILGEGR GFEISQGRLG PGRIHHCMRT VGLAERALQI
660 670 680 690 700
MCERATQRIA FKKKLYAHEV VAHWIAESRI AIEKIRLLTL KAAHSMDTLG
710 720 730 740 750
SAGAKKEIAM IKVAAPRAVS KIVDWAIQVC GGAGVSQDYP LANMYAITRV
760 770 780
LRLADGPDEV HLSAIATMEL RDQAKRLTAK I
Length:781
Mass (Da):87,355
Last modified:October 31, 2006 - v2
Checksum:iCF99D673654FD3DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → T in CAH89526 (Ref. 1) Curated1
Sequence conflicti137V → A in CAH92382 (Ref. 1) Curated1
Sequence conflicti723V → I in CAH89526 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857227 mRNA. Translation: CAH89526.1.
CR860240 mRNA. Translation: CAH92382.1.
RefSeqiNP_001126403.1. NM_001132931.2.

Genome annotation databases

EnsembliENSPPYT00000016405; ENSPPYP00000015783; ENSPPYG00000014106.
GeneIDi100173386.
KEGGipon:100173386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857227 mRNA. Translation: CAH89526.1.
CR860240 mRNA. Translation: CAH92382.1.
RefSeqiNP_001126403.1. NM_001132931.2.

3D structure databases

ProteinModelPortaliQ5R778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000016405; ENSPPYP00000015783; ENSPPYG00000014106.
GeneIDi100173386.
KEGGipon:100173386.

Organism-specific databases

CTDi84129.

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
GeneTreeiENSGT00760000119007.
HOVERGENiHBG057142.
InParanoidiQ5R778.
KOiK11730.
OMAiKECRVIA.
OrthoDBiEOG091G03B8.
TreeFamiTF333953.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACD11_PONAB
AccessioniPrimary (citable) accession number: Q5R778
Secondary accession number(s): Q5RFD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.