Reviewed, UniProtKB/Swiss-Prot Q5R748 (PCYOX_PONAB)

Names and origin

Protein names

Recommended name:
    Prenylcysteine oxidase
    EC=1.8.3.5

Gene names

Name:

PCYOX1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine By similarity.
Catalytic activity	An S-prenyl-L-cysteine + O(2) + H(2)O = a prenal + L-cysteine + H(2)O(2).
Cofactor	FAD By similarity.
Subcellular location	LysosomeBy similarity.
Sequence similarities	Belongs to the prenylcysteine oxidase family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Ligand	FAD
Molecular function	Oxidoreductase
PTM	Glycoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	prenylcysteine oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 505	478	Prenylcysteine oxidase		PRO_0000023301
Amino acid modifications
	Glycosylation	196	1	N-linked (GlcNAc...) Potential
	Glycosylation	323	1	N-linked (GlcNAc...) Potential
	Glycosylation	353	1	N-linked (GlcNAc...) Potential
	Cross-link	162		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R748-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: EA49ACA2F23D1313	FASTA	505	56,752
	10 20 30 40 50 60 MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA YYLRQKFGKD 70 80 90 100 110 120 VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLRMK RFVKDLGLST VQASGGLLGI 130 140 150 160 170 180 YNGETLVFEE SNWFIINVIK LVWRYGFQSL RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE 190 200 210 220 230 240 KLLHALGGDD FLGMLNRTLL ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL 250 260 270 280 290 300 SCSDSGLWAV EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKHTGNPT KMYEVVYQIG 310 320 330 340 350 360 TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG ELNTSIFSSR 370 380 390 400 410 420 PIDKFGLNTV LTTDNSDLFI NSIGIVSSVR EKEDPEPSTD GTYVWKIFSQ ETLTKAQILK 430 440 450 460 470 480 LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL HDRLYYLNGI ECAASAMEMS AIAAHNAALL 490 500 AYHRWNRHTD MIDQDGLYEK LKTEL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860270 mRNA. Translation: CAH92412.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q5R748.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR010795. Prenylcys_lyase. IPR017046. Prenylcysteine_Oxase. [Graphical view]
Pfam	PF07156. Prenylcys_lyase. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PIRSF	PIRSF036292. Prenylcysteine_oxidase. 1 hit.
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

PCYOX_PONAB

Accession

Primary (citable) accession number: Q5R748

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	December 21, 2004
Last modified:	November 4, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)