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Q5R748

- PCYOX_PONAB

UniProt

Q5R748 - PCYOX_PONAB

Protein

Prenylcysteine oxidase

Gene

PCYOX1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine By similarity.By similarity

    Catalytic activityi

    An S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

    Cofactori

    FAD.By similarity

    GO - Molecular functioni

    1. prenylcysteine oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prenylcysteine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prenylcysteine oxidase (EC:1.8.3.5)
    Gene namesi
    Name:PCYOX1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 505478Prenylcysteine oxidasePRO_0000023301Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki162 – 162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiQ5R748.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R748.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the prenylcysteine oxidase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG053532.
    InParanoidiQ5R748.
    KOiK05906.

    Family and domain databases

    InterProiIPR010795. Prenylcys_lyase.
    IPR017046. Prenylcysteine_Oxase.
    [Graphical view]
    PfamiPF07156. Prenylcys_lyase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036292. Prenylcysteine_oxidase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R748-1 [UniParc]FASTAAdd to Basket

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    MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA    50
    YYLRQKFGKD VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLRMK 100
    RFVKDLGLST VQASGGLLGI YNGETLVFEE SNWFIINVIK LVWRYGFQSL 150
    RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE KLLHALGGDD FLGMLNRTLL 200
    ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL SCSDSGLWAV 250
    EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKHTGNPT KMYEVVYQIG 300
    TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG 350
    ELNTSIFSSR PIDKFGLNTV LTTDNSDLFI NSIGIVSSVR EKEDPEPSTD 400
    GTYVWKIFSQ ETLTKAQILK LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL 450
    HDRLYYLNGI ECAASAMEMS AIAAHNAALL AYHRWNRHTD MIDQDGLYEK 500
    LKTEL 505
    Length:505
    Mass (Da):56,752
    Last modified:December 21, 2004 - v1
    Checksum:iEA49ACA2F23D1313
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860270 mRNA. Translation: CAH92412.1.
    RefSeqiNP_001126422.1. NM_001132950.1.
    UniGeneiPab.2816.

    Genome annotation databases

    GeneIDi100457284.
    KEGGipon:100457284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860270 mRNA. Translation: CAH92412.1 .
    RefSeqi NP_001126422.1. NM_001132950.1.
    UniGenei Pab.2816.

    3D structure databases

    ProteinModelPortali Q5R748.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5R748.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100457284.
    KEGGi pon:100457284.

    Organism-specific databases

    CTDi 51449.

    Phylogenomic databases

    HOVERGENi HBG053532.
    InParanoidi Q5R748.
    KOi K05906.

    Family and domain databases

    InterProi IPR010795. Prenylcys_lyase.
    IPR017046. Prenylcysteine_Oxase.
    [Graphical view ]
    Pfami PF07156. Prenylcys_lyase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036292. Prenylcysteine_oxidase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiPCYOX_PONAB
    AccessioniPrimary (citable) accession number: Q5R748
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3