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Q5R748 (PCYOX_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prenylcysteine oxidase

EC=1.8.3.5
Gene names
Name:PCYOX1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine By similarity.

Catalytic activity

An S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

Cofactor

FAD By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the prenylcysteine oxidase family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMGlycoprotein
Isopeptide bond
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprenylcysteine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprenylcysteine oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 505478Prenylcysteine oxidase
PRO_0000023301

Amino acid modifications

Glycosylation1961N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Cross-link162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R748 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: EA49ACA2F23D1313

FASTA50556,752
        10         20         30         40         50         60 
MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA YYLRQKFGKD 

        70         80         90        100        110        120 
VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLRMK RFVKDLGLST VQASGGLLGI 

       130        140        150        160        170        180 
YNGETLVFEE SNWFIINVIK LVWRYGFQSL RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE 

       190        200        210        220        230        240 
KLLHALGGDD FLGMLNRTLL ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL 

       250        260        270        280        290        300 
SCSDSGLWAV EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKHTGNPT KMYEVVYQIG 

       310        320        330        340        350        360 
TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG ELNTSIFSSR 

       370        380        390        400        410        420 
PIDKFGLNTV LTTDNSDLFI NSIGIVSSVR EKEDPEPSTD GTYVWKIFSQ ETLTKAQILK 

       430        440        450        460        470        480 
LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL HDRLYYLNGI ECAASAMEMS AIAAHNAALL 

       490        500 
AYHRWNRHTD MIDQDGLYEK LKTEL 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860270 mRNA. Translation: CAH92412.1.
RefSeqNP_001126422.1. NM_001132950.1.
UniGenePab.2816.

3D structure databases

ProteinModelPortalQ5R748.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R748.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100457284.
KEGGpon:100457284.

Organism-specific databases

CTD51449.

Phylogenomic databases

HOVERGENHBG053532.
InParanoidQ5R748.
KOK05906.

Family and domain databases

InterProIPR010795. Prenylcys_lyase.
IPR017046. Prenylcysteine_Oxase.
[Graphical view]
PfamPF07156. Prenylcys_lyase. 1 hit.
[Graphical view]
PIRSFPIRSF036292. Prenylcysteine_oxidase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePCYOX_PONAB
AccessionPrimary (citable) accession number: Q5R748
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: January 22, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families