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Protein

Calcyclin-binding protein

Gene

CACYBP

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyclin-binding protein
Short name:
CacyBP
Gene namesi
Name:CACYBP
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001853912 – 228Calcyclin-binding proteinAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei85N6-acetyllysineBy similarity1
Modified residuei118N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5R6Z8

Interactioni

Subunit structurei

Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000000558

Structurei

3D structure databases

ProteinModelPortaliQ5R6Z8
SMRiQ5R6Z8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 167CSPROSITE-ProRule annotationAdd BLAST95
Domaini168 – 228SGSPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 80Interaction with SIAH1By similarityAdd BLAST79
Regioni73 – 228Interaction with SKP1By similarityAdd BLAST156
Regioni154 – 228Interaction with S100A6By similarityAdd BLAST75

Phylogenomic databases

eggNOGiKOG3260 Eukaryota
ENOG410XSB6 LUCA
HOVERGENiHBG003242
InParanoidiQ5R6Z8
KOiK04507

Family and domain databases

CDDicd06468 p23_CacyBP, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR037201 CacyBP_N
IPR037893 CS_CacyBP
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR015120 Siah-Interact_N
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
PF09032 Siah-Interact_N, 1 hit
SUPFAMiSSF140106 SSF140106, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R6Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK
60 70 80 90 100
KAELLDNEKP AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP
110 120 130 140 150
TENVQVHFTE RSFDLLVKNL NGKSYSMIVN NLLKPISVEG SSKKVKTDTV
160 170 180 190 200
LILCRKKVEN TRWDYLTQVE KERKEKEKPS YDAETDPSEG LMNVLKKIYE
210 220
DGDDDMKRTI NKAWVESREK QAKGDTEF
Length:228
Mass (Da):26,233
Last modified:December 21, 2004 - v1
Checksum:i737833EA14B6EF94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860325 mRNA Translation: CAH92462.1
RefSeqiNP_001127554.1, NM_001134082.1
UniGeneiPab.4958

Genome annotation databases

GeneIDi100174632
KEGGipon:100174632

Similar proteinsi

Entry informationi

Entry nameiCYBP_PONAB
AccessioniPrimary (citable) accession number: Q5R6Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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