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Q5R6Z8

- CYBP_PONAB

UniProt

Q5R6Z8 - CYBP_PONAB

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Protein

Calcyclin-binding protein

Gene
CACYBP
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) By similarity.

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyclin-binding protein
Short name:
CacyBP
Gene namesi
Name:CACYBP
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 228227Calcyclin-binding proteinPRO_0000185391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei8 – 81N6-acetyllysine By similarity
Modified residuei19 – 191N6-acetyllysine By similarity
Modified residuei85 – 851N6-acetyllysine By similarity
Modified residuei118 – 1181N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R6Z8.
SMRiQ5R6Z8. Positions 1-47, 61-180, 188-218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 16795CSAdd
BLAST
Domaini168 – 22861SGSAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 8079Interaction with SIAH1 By similarityAdd
BLAST
Regioni73 – 228156Interaction with SKP1 By similarityAdd
BLAST
Regioni154 – 22875Interaction with S100A6 By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 CS domain.
Contains 1 SGS domain.

Phylogenomic databases

HOVERGENiHBG003242.
InParanoidiQ5R6Z8.
KOiK04507.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS.
IPR015120. Siah-Interact_N.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF09032. Siah-Interact_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R6Z8-1 [UniParc]FASTAAdd to Basket

« Hide

MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK    50
KAELLDNEKP AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP 100
TENVQVHFTE RSFDLLVKNL NGKSYSMIVN NLLKPISVEG SSKKVKTDTV 150
LILCRKKVEN TRWDYLTQVE KERKEKEKPS YDAETDPSEG LMNVLKKIYE 200
DGDDDMKRTI NKAWVESREK QAKGDTEF 228
Length:228
Mass (Da):26,233
Last modified:December 21, 2004 - v1
Checksum:i737833EA14B6EF94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860325 mRNA. Translation: CAH92462.1.
RefSeqiNP_001127554.1. NM_001134082.1.
UniGeneiPab.4958.

Genome annotation databases

GeneIDi100174632.
KEGGipon:100174632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860325 mRNA. Translation: CAH92462.1 .
RefSeqi NP_001127554.1. NM_001134082.1.
UniGenei Pab.4958.

3D structure databases

ProteinModelPortali Q5R6Z8.
SMRi Q5R6Z8. Positions 1-47, 61-180, 188-218.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174632.
KEGGi pon:100174632.

Organism-specific databases

CTDi 27101.

Phylogenomic databases

HOVERGENi HBG003242.
InParanoidi Q5R6Z8.
KOi K04507.

Family and domain databases

Gene3Di 2.60.40.790. 1 hit.
InterProi IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS.
IPR015120. Siah-Interact_N.
[Graphical view ]
Pfami PF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF09032. Siah-Interact_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49764. SSF49764. 1 hit.
PROSITEi PS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiCYBP_PONAB
AccessioniPrimary (citable) accession number: Q5R6Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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