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Q5R6Z8

- CYBP_PONAB

UniProt

Q5R6Z8 - CYBP_PONAB

Protein

Calcyclin-binding protein

Gene

CACYBP

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) By similarity.By similarity

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcyclin-binding protein
    Short name:
    CacyBP
    Gene namesi
    Name:CACYBP
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 228227Calcyclin-binding proteinPRO_0000185391Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei8 – 81N6-acetyllysineBy similarity
    Modified residuei19 – 191N6-acetyllysineBy similarity
    Modified residuei85 – 851N6-acetyllysineBy similarity
    Modified residuei118 – 1181N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R6Z8.
    SMRiQ5R6Z8. Positions 1-47, 61-180, 188-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 16795CSPROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 22861SGSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 8079Interaction with SIAH1By similarityAdd
    BLAST
    Regioni73 – 228156Interaction with SKP1By similarityAdd
    BLAST
    Regioni154 – 22875Interaction with S100A6By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CS domain.PROSITE-ProRule annotation
    Contains 1 SGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG003242.
    InParanoidiQ5R6Z8.
    KOiK04507.

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    InterProiIPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    IPR007699. SGS.
    IPR015120. Siah-Interact_N.
    [Graphical view]
    PfamiPF04969. CS. 1 hit.
    PF05002. SGS. 1 hit.
    PF09032. Siah-Interact_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49764. SSF49764. 1 hit.
    PROSITEiPS51203. CS. 1 hit.
    PS51048. SGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R6Z8-1 [UniParc]FASTAAdd to Basket

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    MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK    50
    KAELLDNEKP AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP 100
    TENVQVHFTE RSFDLLVKNL NGKSYSMIVN NLLKPISVEG SSKKVKTDTV 150
    LILCRKKVEN TRWDYLTQVE KERKEKEKPS YDAETDPSEG LMNVLKKIYE 200
    DGDDDMKRTI NKAWVESREK QAKGDTEF 228
    Length:228
    Mass (Da):26,233
    Last modified:December 21, 2004 - v1
    Checksum:i737833EA14B6EF94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860325 mRNA. Translation: CAH92462.1.
    RefSeqiNP_001127554.1. NM_001134082.1.
    UniGeneiPab.4958.

    Genome annotation databases

    GeneIDi100174632.
    KEGGipon:100174632.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860325 mRNA. Translation: CAH92462.1 .
    RefSeqi NP_001127554.1. NM_001134082.1.
    UniGenei Pab.4958.

    3D structure databases

    ProteinModelPortali Q5R6Z8.
    SMRi Q5R6Z8. Positions 1-47, 61-180, 188-218.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174632.
    KEGGi pon:100174632.

    Organism-specific databases

    CTDi 27101.

    Phylogenomic databases

    HOVERGENi HBG003242.
    InParanoidi Q5R6Z8.
    KOi K04507.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    InterProi IPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    IPR007699. SGS.
    IPR015120. Siah-Interact_N.
    [Graphical view ]
    Pfami PF04969. CS. 1 hit.
    PF05002. SGS. 1 hit.
    PF09032. Siah-Interact_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49764. SSF49764. 1 hit.
    PROSITEi PS51203. CS. 1 hit.
    PS51048. SGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiCYBP_PONAB
    AccessioniPrimary (citable) accession number: Q5R6Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3