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Q5R6Z8 (CYBP_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcyclin-binding protein

Short name=CacyBP
Gene names
Name:CACYBP
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) By similarity.

Subunit structure

Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner. Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Post-translational modification

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations By similarity.

Sequence similarities

Contains 1 CS domain.

Contains 1 SGS domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 228227Calcyclin-binding protein
PRO_0000185391

Regions

Domain73 – 16795CS
Domain168 – 22861SGS
Region2 – 8079Interaction with SIAH1 By similarity
Region73 – 228156Interaction with SKP1 By similarity
Region154 – 22875Interaction with S100A6 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue81N6-acetyllysine By similarity
Modified residue191N6-acetyllysine By similarity
Modified residue851N6-acetyllysine By similarity
Modified residue1181N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R6Z8 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 737833EA14B6EF94

FASTA22826,233
        10         20         30         40         50         60 
MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP 

        70         80         90        100        110        120 
AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL 

       130        140        150        160        170        180 
NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KERKEKEKPS 

       190        200        210        220 
YDAETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860325 mRNA. Translation: CAH92462.1.
RefSeqNP_001127554.1. NM_001134082.1.
UniGenePab.4958.

3D structure databases

ProteinModelPortalQ5R6Z8.
SMRQ5R6Z8. Positions 1-47, 61-180, 188-218.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174632.
KEGGpon:100174632.

Organism-specific databases

CTD27101.

Phylogenomic databases

HOVERGENHBG003242.
InParanoidQ5R6Z8.
KOK04507.

Family and domain databases

Gene3D2.60.40.790. 1 hit.
InterProIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS.
IPR015120. Siah-Interact_N.
[Graphical view]
PfamPF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF09032. Siah-Interact_N. 1 hit.
[Graphical view]
SUPFAMSSF49764. SSF49764. 1 hit.
PROSITEPS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYBP_PONAB
AccessionPrimary (citable) accession number: Q5R6Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families