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Protein

Death domain-containing protein CRADD

Gene

CRADD

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing protein CRADD
Alternative name(s):
Caspase and RIP adapter with death domain
Gene namesi
Name:CRADD
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Death domain-containing protein CRADDPRO_0000079328Add
BLAST

Interactioni

Subunit structurei

Interacts with LRDD.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005515.

Structurei

3D structure databases

ProteinModelPortaliQ5R6I4.
SMRiQ5R6I4. Positions 1-100, 109-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
BLAST
Domaini116 – 18873DeathPROSITE-ProRule annotationAdd
BLAST

Domaini

Contains a death domain involved in the binding of RIP protein.By similarity
The CARD domain mediates the interaction with caspase-2.By similarity

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
GeneTreeiENSGT00390000014448.
HOVERGENiHBG051112.
InParanoidiQ5R6I4.
KOiK02832.
OMAiLGPEWEH.
OrthoDBiEOG091G0M3P.
TreeFamiTF333055.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R6I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARDKQVLR LLRLELGAEV LVEGLVLQYL YQEGILTENH VQEINAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG
110 120 130 140 150
DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Length:199
Mass (Da):22,725
Last modified:December 21, 2004 - v1
Checksum:i47B923B3B6F68F59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860505 mRNA. Translation: CAH92626.1.
RefSeqiNP_001126538.1. NM_001133066.1.
XP_009246375.1. XM_009248100.1.
XP_009246376.1. XM_009248101.1.
UniGeneiPab.11875.

Genome annotation databases

EnsembliENSPPYT00000005728; ENSPPYP00000005515; ENSPPYG00000004835.
GeneIDi100173528.
KEGGipon:100173528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860505 mRNA. Translation: CAH92626.1.
RefSeqiNP_001126538.1. NM_001133066.1.
XP_009246375.1. XM_009248100.1.
XP_009246376.1. XM_009248101.1.
UniGeneiPab.11875.

3D structure databases

ProteinModelPortaliQ5R6I4.
SMRiQ5R6I4. Positions 1-100, 109-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005515.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000005728; ENSPPYP00000005515; ENSPPYG00000004835.
GeneIDi100173528.
KEGGipon:100173528.

Organism-specific databases

CTDi8738.

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
GeneTreeiENSGT00390000014448.
HOVERGENiHBG051112.
InParanoidiQ5R6I4.
KOiK02832.
OMAiLGPEWEH.
OrthoDBiEOG091G0M3P.
TreeFamiTF333055.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRADD_PONAB
AccessioniPrimary (citable) accession number: Q5R6I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.