Q5R6H6 (DUS26_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase 26
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:

DUSP26

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Interacts with HSF4 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Golgi apparatus By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Golgi apparatus Nucleus
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Dual specificity protein phosphatase 26		PRO_0000292221
Regions
	Domain	61 – 206	146	Tyrosine-protein phosphatase
Sites
	Active site	152	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R6H6 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 8F13442A42D3D8DD	FASTA	211	23,959
	10 20 30 40 50 60 MCPGNWLWAS MTFMARFSRS SSRSPVRTRG NLEEMPTVQH PFLNVFELER LLYTGKTACN 70 80 90 100 110 120 HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR GTPEAYEGLG IRYLGVEAHD 130 140 150 160 170 180 SPAFDMSIHF QTAADFIHRA LSQPGGKILV HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK 190 200 210 KVKDHRGIIP NRGFLRQLLA LDRRLRQGLE A

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860513 mRNA. Translation: CAH92640.1.
RefSeq	NP_001126545.1. NM_001133073.1.
UniGene	Pab.11894.
3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
ProteinModelPortal	Q5R6H6.
SMR	Q5R6H6. Positions 61-210.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000021569; ENSPPYP00000020739; ENSPPYG00000018499.
GeneID	100173535.
KEGG	pon:100173535.
Organism-specific databases
CTD	78986.
Phylogenomic databases
GeneTree	ENSGT00550000074474.
HOVERGEN	HBG001524.
InParanoid	Q5R6H6.
KO	K14165.
OMA	PAVQHPF.
OrthoDB	EOG4BCDP2.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUS26_PONAB

Accession

Primary (citable) accession number: Q5R6H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program