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Q5R6H6

- DUS26_PONAB

UniProt

Q5R6H6 - DUS26_PONAB

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Protein
Dual specificity protein phosphatase 26
Gene
DUSP26
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:DUSP26
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 8

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Golgi apparatus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Dual specificity protein phosphatase 26
    PRO_0000292221Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with HSF4 By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R6H6.
    SMRiQ5R6H6. Positions 61-210.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 206146Tyrosine-protein phosphatase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00550000074474.
    HOVERGENiHBG001524.
    InParanoidiQ5R6H6.
    KOiK14165.
    OMAiMAFMSRF.
    OrthoDBiEOG7CZK7N.
    TreeFamiTF105128.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5R6H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPGNWLWAS MTFMARFSRS SSRSPVRTRG NLEEMPTVQH PFLNVFELER    50
    LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR 100
    GTPEAYEGLG IRYLGVEAHD SPAFDMSIHF QTAADFIHRA LSQPGGKILV 150
    HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK KVKDHRGIIP NRGFLRQLLA 200
    LDRRLRQGLE A 211
    Length:211
    Mass (Da):23,959
    Last modified:December 21, 2004 - v1
    Checksum:i8F13442A42D3D8DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860513 mRNA. Translation: CAH92640.1.
    RefSeqiNP_001126545.1. NM_001133073.1.
    UniGeneiPab.11894.

    Genome annotation databases

    EnsembliENSPPYT00000021569; ENSPPYP00000020739; ENSPPYG00000018499.
    GeneIDi100173535.
    KEGGipon:100173535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860513 mRNA. Translation: CAH92640.1 .
    RefSeqi NP_001126545.1. NM_001133073.1.
    UniGenei Pab.11894.

    3D structure databases

    ProteinModelPortali Q5R6H6.
    SMRi Q5R6H6. Positions 61-210.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000021569 ; ENSPPYP00000020739 ; ENSPPYG00000018499 .
    GeneIDi 100173535.
    KEGGi pon:100173535.

    Organism-specific databases

    CTDi 78986.

    Phylogenomic databases

    GeneTreei ENSGT00550000074474.
    HOVERGENi HBG001524.
    InParanoidi Q5R6H6.
    KOi K14165.
    OMAi MAFMSRF.
    OrthoDBi EOG7CZK7N.
    TreeFami TF105128.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiDUS26_PONAB
    AccessioniPrimary (citable) accession number: Q5R6H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: December 21, 2004
    Last modified: June 11, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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