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Q5R6H6

- DUS26_PONAB

UniProt

Q5R6H6 - DUS26_PONAB

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Protein

Dual specificity protein phosphatase 26

Gene

DUSP26

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. phosphoserine phosphatase activity Source: Ensembl
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  2. negative regulation of protein kinase activity by regulation of protein phosphorylation Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. positive regulation of cell adhesion Source: Ensembl
  5. positive regulation of peptidyl-serine dephosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DUSP26
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 8

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Golgi apparatus By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. Golgi apparatus Source: UniProtKB-KW
  3. mitochondrion Source: Ensembl
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Dual specificity protein phosphatase 26PRO_0000292221Add
BLAST

Interactioni

Subunit structurei

Interacts with HSF4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5R6H6.
SMRiQ5R6H6. Positions 61-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 206146Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118853.
HOVERGENiHBG001524.
InParanoidiQ5R6H6.
KOiK14165.
OMAiMAFMSRF.
OrthoDBiEOG7CZK7N.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R6H6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCPGNWLWAS MTFMARFSRS SSRSPVRTRG NLEEMPTVQH PFLNVFELER
60 70 80 90 100
LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR
110 120 130 140 150
GTPEAYEGLG IRYLGVEAHD SPAFDMSIHF QTAADFIHRA LSQPGGKILV
160 170 180 190 200
HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK KVKDHRGIIP NRGFLRQLLA
210
LDRRLRQGLE A
Length:211
Mass (Da):23,959
Last modified:December 21, 2004 - v1
Checksum:i8F13442A42D3D8DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860513 mRNA. Translation: CAH92640.1.
RefSeqiNP_001126545.1. NM_001133073.1.
UniGeneiPab.11894.

Genome annotation databases

EnsembliENSPPYT00000021569; ENSPPYP00000020739; ENSPPYG00000018499.
GeneIDi100173535.
KEGGipon:100173535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860513 mRNA. Translation: CAH92640.1 .
RefSeqi NP_001126545.1. NM_001133073.1.
UniGenei Pab.11894.

3D structure databases

ProteinModelPortali Q5R6H6.
SMRi Q5R6H6. Positions 61-210.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000021569 ; ENSPPYP00000020739 ; ENSPPYG00000018499 .
GeneIDi 100173535.
KEGGi pon:100173535.

Organism-specific databases

CTDi 78986.

Phylogenomic databases

GeneTreei ENSGT00760000118853.
HOVERGENi HBG001524.
InParanoidi Q5R6H6.
KOi K14165.
OMAi MAFMSRF.
OrthoDBi EOG7CZK7N.
TreeFami TF105128.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiDUS26_PONAB
AccessioniPrimary (citable) accession number: Q5R6H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3