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Q5R6F1

- MESD_PONAB

UniProt

Q5R6F1 - MESD_PONAB

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Protein

LDLR chaperone MESD

Gene
MESDC2, MESD
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction By similarity.

GO - Biological processi

  1. protein folding Source: UniProtKB
  2. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:MESDC2
Synonyms:MESD
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 234201LDLR chaperone MESDPRO_0000240319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R6F1.
SMRiQ5R6F1. Positions 98-193.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 164164Chaperone domain By similarityAdd
BLAST
Regioni165 – 20440Escort domain By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi231 – 2344Prevents secretion from ER

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity.
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.

Sequence similaritiesi

Belongs to the MESD family.

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ5R6F1.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R6F1-1 [UniParc]FASTAAdd to Basket

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MAASSWARKA VVVLCASDLL LLLLLLPPPG SCAAEASPGT PDESTPPPRK    50
KKKDIRDYND ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK 100
PESILKMTKK GKTLMMFVTV SGSPTEKETE EITSLWQGSL FNANYDVQRF 150
IVGSDRAIFM LRDGNYAWEI KDFLVGQDRC ADVTLEGQVY PGKGGGSKEK 200
NKTKQDKGKK KKEGDLKSRS SKEDNRARNK REDL 234
Length:234
Mass (Da):26,120
Last modified:December 21, 2004 - v1
Checksum:i952FCB4BA2B672DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860539 mRNA. Translation: CAH92665.1.
RefSeqiNP_001127574.1. NM_001134102.1.
UniGeneiPab.1436.

Genome annotation databases

GeneIDi100174652.
KEGGipon:100174652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860539 mRNA. Translation: CAH92665.1 .
RefSeqi NP_001127574.1. NM_001134102.1.
UniGenei Pab.1436.

3D structure databases

ProteinModelPortali Q5R6F1.
SMRi Q5R6F1. Positions 98-193.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174652.
KEGGi pon:100174652.

Organism-specific databases

CTDi 102367458.

Phylogenomic databases

InParanoidi Q5R6F1.

Family and domain databases

InterProi IPR019330. Mesoderm_development_cand-2.
[Graphical view ]
Pfami PF10185. Mesd. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiMESD_PONAB
AccessioniPrimary (citable) accession number: Q5R6F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 21, 2004
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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