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Q5R6F1 (MESD_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene names
Name:MESDC2
Synonyms:MESD
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction By similarity.

Subunit structure

Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Domain

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity.

The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.

Sequence similarities

Belongs to the MESD family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionChaperone
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

protein folding

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 234201LDLR chaperone MESD
PRO_0000240319

Regions

Region1 – 164164Chaperone domain By similarity
Region165 – 20440Escort domain By similarity
Motif231 – 2344Prevents secretion from ER

Amino acid modifications

Glycosylation2011N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5R6F1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 952FCB4BA2B672DC

FASTA23426,120
        10         20         30         40         50         60 
MAASSWARKA VVVLCASDLL LLLLLLPPPG SCAAEASPGT PDESTPPPRK KKKDIRDYND 

        70         80         90        100        110        120 
ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK PESILKMTKK GKTLMMFVTV 

       130        140        150        160        170        180 
SGSPTEKETE EITSLWQGSL FNANYDVQRF IVGSDRAIFM LRDGNYAWEI KDFLVGQDRC 

       190        200        210        220        230 
ADVTLEGQVY PGKGGGSKEK NKTKQDKGKK KKEGDLKSRS SKEDNRARNK REDL 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860539 mRNA. Translation: CAH92665.1.
RefSeqNP_001127574.1. NM_001134102.1.
UniGenePab.1436.

3D structure databases

ProteinModelPortalQ5R6F1.
SMRQ5R6F1. Positions 98-193.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174652.
KEGGpon:100174652.

Organism-specific databases

CTD57214.

Phylogenomic databases

InParanoidQ5R6F1.

Family and domain databases

InterProIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamPF10185. Mesd. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMESD_PONAB
AccessionPrimary (citable) accession number: Q5R6F1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families