Reviewed, UniProtKB/Swiss-Prot Q5R6B5 (AL1B1_PONAB)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase X, mitochondrial
    EC=1.2.1.3
Alternative name(s):
    Aldehyde dehydrogenase family 1 member B1

Gene names

Name:	ALDH1B1
Synonyms:	ALDHX

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation By similarity.
Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 17	17	Mitochondrion Potential
	Chain	18 – 517	500	Aldehyde dehydrogenase X, mitochondrial		PRO_0000271412
Regions
	Nucleotide binding	262 – 267	6	NAD By similarity
Sites
	Active site	285	1	Proton acceptor By similarity
	Active site	319	1	Nucleophile By similarity
	Site	186	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R6B5-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 105F47E5840D4229	FASTA	517	57,261
	10 20 30 40 50 60 MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT 70 80 90 100 110 120 TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNCLAD LVERDRVYLA 130 140 150 160 170 180 SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPIGVCG 190 200 210 220 230 240 QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG 250 260 270 280 290 300 YGPTAGAAIA QHMDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM 310 320 330 340 350 360 EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP 370 380 390 400 410 420 QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP 430 440 450 460 470 480 VQPLFKFKKM EEVIERANTT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT 490 500 510 PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860576 mRNA. Translation: CAH92701.1.
RefSeq	NP_001127576.1.
UniGene	Pab.18715
3D structure databases
HSSP	HSSP built from PDB template 1ZUM based on UniProtKB P05091.
SMR	Q5R6B5. Positions 25-517.
ModBase	Search...
Genome annotation databases
GeneID	100174654.
Organism-specific databases
CTD	100174654.
Phylogenomic databases
HOVERGEN	Q5R6B5.
InParanoid	Q5R6B5.
Enzyme and pathway databases
BRENDA	1.2.1.3. 269192.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL1B1_PONAB

Accession

Primary (citable) accession number: Q5R6B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	December 21, 2004
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)