Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5R6B5

- AL1B1_PONAB

UniProt

Q5R6B5 - AL1B1_PONAB

Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

ALDH1B1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation By similarity.By similarity

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei186 – 1861Transition state stabilizerBy similarity
    Active sitei285 – 2851Proton acceptorPROSITE-ProRule annotation
    Active sitei319 – 3191NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi262 – 2676NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
    Alternative name(s):
    Aldehyde dehydrogenase family 1 member B1
    Gene namesi
    Name:ALDH1B1
    Synonyms:ALDHX
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1717MitochondrionSequence AnalysisAdd
    BLAST
    Chaini18 – 517500Aldehyde dehydrogenase X, mitochondrialPRO_0000271412Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-acetyllysineBy similarity
    Modified residuei52 – 521N6-acetyllysine; alternateBy similarity
    Modified residuei52 – 521N6-succinyllysine; alternateBy similarity
    Modified residuei81 – 811N6-succinyllysineBy similarity
    Modified residuei364 – 3641N6-acetyllysine; alternateBy similarity
    Modified residuei364 – 3641N6-succinyllysine; alternateBy similarity
    Modified residuei383 – 3831N6-acetyllysine; alternateBy similarity
    Modified residuei383 – 3831N6-succinyllysine; alternateBy similarity
    Modified residuei399 – 3991N6-acetyllysine; alternateBy similarity
    Modified residuei399 – 3991N6-succinyllysine; alternateBy similarity
    Modified residuei414 – 4141N6-acetyllysine; alternateBy similarity
    Modified residuei414 – 4141N6-succinyllysine; alternateBy similarity
    Modified residuei426 – 4261N6-acetyllysine; alternateBy similarity
    Modified residuei426 – 4261N6-succinyllysine; alternateBy similarity
    Modified residuei429 – 4291N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ5R6B5.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R6B5.
    SMRiQ5R6B5. Positions 25-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG000097.
    InParanoidiQ5R6B5.
    KOiK00128.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R6B5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS    50
    KKTFPTVNPT TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE 100
    RGRLLNCLAD LVERDRVYLA SLETLDNGKP FQESYALDLD EVIKVYRYFA 150
    GWADKWHGKT IPMDGQHFCF TRHEPIGVCG QIIPWNFPLV MQGWKLAPAL 200
    ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG YGPTAGAAIA 250
    QHMDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM 300
    EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN 350
    PFELDTQQGP QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP 400
    TVFGGVQDDM RIAKEEIFGP VQPLFKFKKM EEVIERANTT RYGLAAAVFT 450
    RDLDKAMYFT QALQAGTVWV NTYNIVTCHT PFGGFKESGN GRELGEDGLK 500
    AYTEVKTVTI KVPQKNS 517
    Length:517
    Mass (Da):57,261
    Last modified:December 21, 2004 - v1
    Checksum:i105F47E5840D4229
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860576 mRNA. Translation: CAH92701.1.
    RefSeqiNP_001127576.1. NM_001134104.1.

    Genome annotation databases

    GeneIDi100174654.
    KEGGipon:100174654.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR860576 mRNA. Translation: CAH92701.1 .
    RefSeqi NP_001127576.1. NM_001134104.1.

    3D structure databases

    ProteinModelPortali Q5R6B5.
    SMRi Q5R6B5. Positions 25-517.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5R6B5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174654.
    KEGGi pon:100174654.

    Organism-specific databases

    CTDi 219.

    Phylogenomic databases

    HOVERGENi HBG000097.
    InParanoidi Q5R6B5.
    KOi K00128.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiAL1B1_PONAB
    AccessioniPrimary (citable) accession number: Q5R6B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3