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Reviewed, UniProtKB/Swiss-Prot Q5R6B1 (LRRT1_PONAB)

Last modified October 13, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Leucine-rich repeat transmembrane neuronal protein 1
Gene names
Name: LRRTM1
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May play a role during the development of specific forebrain structures by influencing neuronal differentiation and connectivity, with a possible role in intracellular trafficking within axons By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the LRRTM family.

Contains 10 LRR (leucine-rich) repeats.

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 522488Leucine-rich repeat transmembrane neuronal protein 1
PRO_0000018352

Regions

Topological domain35 – 427393Lumenal Potential
Transmembrane428 – 44821 Potential
Topological domain449 – 52274Cytoplasmic Potential
Repeat64 – 8724LRR 1
Repeat89 – 11123LRR 2
Repeat112 – 13524LRR 3
Repeat137 – 15923LRR 4
Repeat161 – 18323LRR 5
Repeat184 – 20724LRR 6
Repeat209 – 23123LRR 7
Repeat233 – 25422LRR 8
Repeat255 – 27824LRR 9
Repeat279 – 30224LRR 10

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation3801N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict571P → L in CAI29644. Ref.1
Sequence conflict5011L → P in CAI29644. Ref.1
Sequence conflict5201C → R in CAI29644. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q5R6B1-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: EDBAD67526005793

FASTA52258,597
        10         20         30         40         50         60 
MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNPTEA 

        70         80         90        100        110        120 
PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL 

       130        140        150        160        170        180 
SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI 

       190        200        210        220        230        240 
FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL 

       250        260        270        280        290        300 
RRNKVAIVVS SLDWVWNLKK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL 

       310        320        330        340        350        360 
NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDGNL QCASPEYAQG EDVLDAVYAF 

       370        380        390        400        410        420 
HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG QHDGTFEPAT VALPGGEHAE 

       430        440        450        460        470        480 
NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM 

       490        500        510        520 
AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV

« Hide

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

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Web resources

Protein Spotlight

The hands to say it - Issue 91 of February 2008

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Cross-references

Sequence databases

CR860580 mRNA. Translation: CAH92705.1.
CR926006 mRNA. Translation: CAI29644.1.
RefSeqNP_001126583.1.
UniGenePab.18416

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID100173575.

Organism-specific databases

CTD100173575.

Phylogenomic databases

HOVERGENQ5R6B1.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR000372. Leu-rich_rpt_Cys-rich-dom_N.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamPF00560. LRR_1. 5 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLRRT1_PONAB
AccessionPrimary (citable) accession number: Q5R6B1
Secondary accession number(s): Q5NVL9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 21, 2004
Last modified: October 13, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents