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Protein

Low-density lipoprotein receptor-related protein 12

Gene

LRP12

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 12
Short name:
LRP-12
Gene namesi
Name:LRP12
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 492ExtracellularSequence analysisAdd BLAST460
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 859CytoplasmicSequence analysisAdd BLAST346

Keywords - Cellular componenti

Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000035267233 – 859Low-density lipoprotein receptor-related protein 12Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 76By similarity
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 122By similarity
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Disulfide bondi215 ↔ 232By similarity
Disulfide bondi222 ↔ 245By similarity
Disulfide bondi239 ↔ 254By similarity
Disulfide bondi259 ↔ 285By similarity
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi375 ↔ 388By similarity
Disulfide bondi382 ↔ 401By similarity
Disulfide bondi395 ↔ 410By similarity
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi413 ↔ 426By similarity
Disulfide bondi420 ↔ 439By similarity
Disulfide bondi433 ↔ 448By similarity
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi451 ↔ 463By similarity
Disulfide bondi458 ↔ 476By similarity
Disulfide bondi470 ↔ 485By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

May interact with RACK1, ZFYVE9 and NMRK2.By similarity

Structurei

3D structure databases

SMRiQ5R662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 159CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini165 – 201LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini214 – 255LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST42
Domaini259 – 372CUB 2PROSITE-ProRule annotationAdd BLAST114
Domaini374 – 411LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini412 – 449LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini450 – 486LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT2 Eukaryota
ENOG410YUIT LUCA
GeneTreeiENSGT00810000125405
HOGENOMiHOG000013017
HOVERGENiHBG103190
InParanoidiQ5R662
KOiK20050
OMAiHTAQIPD
OrthoDBiEOG091G0I9Q
TreeFamiTF332149

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00112 LDLa, 5 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00057 Ldl_recept_a, 4 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00192 LDLa, 5 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF57424 SSF57424, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5R662-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET
60 70 80 90 100
PEQIRAPSGI ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS
110 120 130 140 150
RRCNLDWLTI ETYKNIESYR ACGSTIPPPY ISSQDHIWIR FHSDDNISRK
160 170 180 190 200
GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP EAWKCNNMDE CGDSSDEEIC
210 220 230 240 250
AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD GNIDCLDLGD
260 270 280 290 300
EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR
310 320 330 340 350
FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI
360 370 380 390 400
RVHFCADKVN AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH
410 420 430 440 450
CPNGRDEINC TMCQKEEFPC SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF
460 470 480 490 500
CQPGNFHCKN NRCVFESWVC DSQDDCGDGS DEENCPVIVP TRVITAAVIG
510 520 530 540 550
SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL LRREAPPSYG
560 570 580 590 600
QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS
610 620 630 640 650
NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV
660 670 680 690 700
ESDDTDTENE RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST
710 720 730 740 750
RGGHADNGRD VTSVEPPSVS PARHQLTSAL SRMTQGLRWV RFTLGRSSSV
760 770 780 790 800
SQNQSPLRQL DNGVSGREDD DDVEMLIPIS DGSSDFDVND CSRPLLDLAS
810 820 830 840 850
DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT CLEVTLKNET

SDDEALLLC
Length:859
Mass (Da):95,035
Last modified:October 14, 2008 - v2
Checksum:i37902D89FFDC02C2
GO
Isoform 2 (identifier: Q5R662-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-45: Missing.

Show »
Length:840
Mass (Da):93,174
Checksum:i976EE43304BD096B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66W → R in CAH92835 (Ref. 1) Curated1
Sequence conflicti140R → S in CAH92835 (Ref. 1) Curated1
Sequence conflicti452Q → H in CAH92754 (Ref. 1) Curated1
Sequence conflicti608N → S in CAH92754 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03557827 – 45Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860634 mRNA Translation: CAH92754.1
CR860720 mRNA Translation: CAH92835.1
RefSeqiNP_001126606.1, NM_001133134.1
NP_001128879.1, NM_001135407.1
UniGeneiPab.18699

Genome annotation databases

EnsembliENSPPYT00000021947; ENSPPYP00000021104; ENSPPYG00000018813 [Q5R662-1]
GeneIDi100173603
KEGGipon:100173603
pon:100189811

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLRP12_PONAB
AccessioniPrimary (citable) accession number: Q5R662
Secondary accession number(s): Q5R5Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health