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Q5R636

- PFKAP_PONAB

UniProt

Q5R636 - PFKAP_PONAB

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Protein
ATP-dependent 6-phosphofructokinase, platelet type
Gene
PFKP
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotation

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP; via amide nitrogen By similarity
Metal bindingi128 – 1281Magnesium; catalytic By similarity
Active sitei175 – 1751Proton acceptor By similarity
Binding sitei210 – 2101Substrate; shared with dimeric partner By similarity
Binding sitei273 – 2731Substrate By similarity
Binding sitei301 – 3011Substrate; shared with dimeric partner By similarity
Binding sitei481 – 4811Allosteric activator fructose 2,6-bisphosphate By similarity
Binding sitei576 – 5761Allosteric activator fructose 2,6-bisphosphate; shared with dimeric partner By similarity
Binding sitei639 – 6391Allosteric activator fructose 2,6-bisphosphate By similarity
Binding sitei665 – 6651Allosteric activator fructose 2,6-bisphosphate; shared with dimeric partner By similarity
Binding sitei744 – 7441Allosteric activator fructose 2,6-bisphosphate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 982ATP By similarity
Nucleotide bindingi127 – 1304ATP By similarity

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. fructose 6-phosphate metabolic process Source: InterPro
  3. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinase, platelet type (EC:2.7.1.11)
Short name:
ATP-PFK
Short name:
PFK-P
Alternative name(s):
6-phosphofructokinase type C
Phosphofructo-1-kinase isozyme C
Short name:
PFK-C
Phosphohexokinase
Gene namesi
Name:PFKP
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 784784ATP-dependent 6-phosphofructokinase, platelet typeUniRule annotation
PRO_0000284442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei12 – 121Phosphoserine By similarity
Modified residuei386 – 3861Phosphoserine By similarity
Modified residuei395 – 3951N6-acetyllysine By similarity
Modified residuei486 – 4861N6-acetyllysine By similarity
Glycosylationi540 – 5401O-linked (GlcNAc) By similarity
Modified residuei651 – 6511Phosphotyrosine By similarity
Modified residuei688 – 6881N6-acetyllysine By similarity
Modified residuei783 – 7831Phosphoserine By similarity

Post-translational modificationi

GlcNAcylation decreases enzyme activity By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ5R636.

Interactioni

Subunit structurei

Homo- and heterotetramers By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5R636.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 399399N-terminal catalytic PFK domain 1UniRule annotation
Add
BLAST
Regioni173 – 1753Substrate binding By similarity
Regioni217 – 2193Substrate binding By similarity
Regioni307 – 3104Substrate binding By similarity
Regioni400 – 41112Interdomain linkerUniRule annotation
Add
BLAST
Regioni412 – 784373C-terminal regulatory PFK domain 2UniRule annotation
Add
BLAST
Regioni538 – 5425Allosteric activator fructose 2,6-bisphosphate binding By similarity
Regioni583 – 5853Allosteric activator fructose 2,6-bisphosphate binding By similarity
Regioni671 – 6744Allosteric activator fructose 2,6-bisphosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000976.
InParanoidiQ5R636.
KOiK00850.

Family and domain databases

HAMAPiMF_03184. Phosphofructokinase_I_E.
InterProiIPR009161. 6-phosphofructokinase_euk.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 2 hits.
[Graphical view]
PIRSFiPIRSF000533. ATP_PFK_euk. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 2 hits.
TIGRFAMsiTIGR02478. 6PF1K_euk. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R636-1 [UniParc]FASTAAdd to Basket

« Hide

MDADDSRAPK GSLRKFLEHL SGAGKAIGVL TSGGDAQGMN AAVRAVVRMG    50
IYVGAKVCFI YEGYQGMVDG GSNIAEADWE SVSSILQVGG TIIGSARCQA 100
FRTREGRLKA ACNLLQRGIT NLCVIGGDGS LTGANLFRKE WSGLLEELAR 150
NGQIDKEAVQ KYAYLNVVGM VGSIDNDFCG TDMTIGTDSA LHRIIEVVDA 200
IMTTAQSHQR TFVLEVMGRH CGYLALVSAL ACGADWVFLP ESPPEEGWEE 250
QMCVKLSENR ARKKRLNIII VAEGAIDTQN KPITSEKIKE LVVTQLGYDT 300
RVTILGHVQR GGTPSAFDRI LASRMGVEAV IALLEATPDT PACVVSLNGN 350
HAVRLPLMEC VQMTQDVQKA MDERRFQDAV RLRGRSFAGN LNTYKRLAIK 400
LPDDQIPKTN CNVAVINVGA PAAGMNAAVR SAVRVGIADG HRMLAIYDGF 450
DGFAKGQIKE IGWTDVGGWT GQGGSILGTK RVLPGKYLEE IATQMRTHSI 500
NALLIIGGFE AYLGLLELSA AREKHEEFCV PMVMVPATVS NNVPGSDFSI 550
GADTALNTIT DTCDRIKQSA SGTKRRVFII ETMGGYCGYL ANMGGLAAGA 600
DAAYIFEEPF DIRDLQSSVE HLTEKMKTTI QRGLVLRNES CSENYTTDFI 650
YQLYSEEGKG VFDCRKNVLG HMQQGGAPSP FDRNFGTKIS ARAMEWITAK 700
LKETRGRGKK FTTDDSVCVL GISKRNVIFQ PVAELKKQTD FEHRIPKEQW 750
WLKLRPLMKI LAKYKASYDV SDSGQLEHVQ PWSV 784
Length:784
Mass (Da):85,525
Last modified:December 21, 2004 - v1
Checksum:i6DC468B4629E235D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860660 mRNA. Translation: CAH92780.1.
RefSeqiNP_001126622.1. NM_001133150.1.
UniGeneiPab.4970.

Genome annotation databases

GeneIDi100173619.
KEGGipon:100173619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR860660 mRNA. Translation: CAH92780.1 .
RefSeqi NP_001126622.1. NM_001133150.1.
UniGenei Pab.4970.

3D structure databases

ProteinModelPortali Q5R636.
ModBasei Search...

Proteomic databases

PRIDEi Q5R636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100173619.
KEGGi pon:100173619.

Organism-specific databases

CTDi 5214.

Phylogenomic databases

HOVERGENi HBG000976.
InParanoidi Q5R636.
KOi K00850.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .

Family and domain databases

HAMAPi MF_03184. Phosphofructokinase_I_E.
InterProi IPR009161. 6-phosphofructokinase_euk.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 2 hits.
[Graphical view ]
PIRSFi PIRSF000533. ATP_PFK_euk. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 2 hits.
TIGRFAMsi TIGR02478. 6PF1K_euk. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPFKAP_PONAB
AccessioniPrimary (citable) accession number: Q5R636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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