Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Relaxin receptor 1

Gene

RXFP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Calcium; via carbonyl oxygenBy similarity
Metal bindingi48 – 481CalciumBy similarity
Metal bindingi50 – 501Calcium; via carbonyl oxygenBy similarity
Metal bindingi52 – 521CalciumBy similarity
Metal bindingi58 – 581CalciumBy similarity
Metal bindingi59 – 591CalciumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 1
Alternative name(s):
Relaxin family peptide receptor 1
Gene namesi
Name:RXFP1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 408408ExtracellularSequence analysisAdd
BLAST
Transmembranei409 – 42921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini430 – 44314CytoplasmicSequence analysisAdd
BLAST
Transmembranei444 – 46421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini465 – 48622ExtracellularSequence analysisAdd
BLAST
Transmembranei487 – 50721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini508 – 52720CytoplasmicSequence analysisAdd
BLAST
Transmembranei528 – 54821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini549 – 57729ExtracellularSequence analysisAdd
BLAST
Transmembranei578 – 59821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini599 – 62931CytoplasmicSequence analysisAdd
BLAST
Transmembranei630 – 65021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini651 – 66010ExtracellularSequence analysis
Transmembranei661 – 68121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini682 – 75776CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Relaxin receptor 1PRO_0000312668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 40By similarity
Disulfide bondi34 ↔ 53By similarity
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi47 ↔ 62By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi485 ↔ 563By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016938.

Structurei

3D structure databases

ProteinModelPortaliQ5R5V8.
SMRiQ5R5V8. Positions 21-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6338LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Domaini91 – 12737LRRNTAdd
BLAST
Repeati151 – 17222LRR 1Add
BLAST
Repeati175 – 19622LRR 2Add
BLAST
Repeati199 – 22022LRR 3Add
BLAST
Repeati223 – 24422LRR 4Add
BLAST
Repeati248 – 26922LRR 5Add
BLAST
Repeati272 – 29322LRR 6Add
BLAST
Repeati296 – 31722LRR 7Add
BLAST
Repeati320 – 34122LRR 8Add
BLAST
Repeati344 – 36522LRR 9Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
ENOG410Z84K. LUCA.
HOVERGENiHBG026354.
InParanoidiQ5R5V8.
KOiK04306.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R5V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGSVFFYI LIIGKYFSHG GGQDVKCSLG YFPCGNITKC LPQLLHCNGV
60 70 80 90 100
DDCGNQADED NCGDNNGWSL QFDKYFASYY KMTSQYPFEA ETPECLVGSV
110 120 130 140 150
PVQCLCRGLE LDCDETNLRA VPSVSSNVTA MSLQWNLIRK LPPDCFKNYH
160 170 180 190 200
DLQKLYLQNN KITSISIYAF RGLNSLTKLY LSHNRITFLK PGVFEDLHRL
210 220 230 240 250
EWLIIEDNHL SRISPPTFYG LNSLILLVLM NNVLTRLPDK PLCQHMPRLH
260 270 280 290 300
WLDLEGNHIH NLRNLTLISC SNLTVLVMGK NKINHLNENT FAPLQKLDEL
310 320 330 340 350
DLGSNKIENL PPLIFKDLKE LSQLNLSYNP IQKIQANQFD YLVKLKSLSL
360 370 380 390 400
EGIEISNIQQ RMFRPLMNLS HIYFKKFQYC GYAPHVRSGK PNTDGISSLE
410 420 430 440 450
NLLASIIQRV FVWVVSAVTC FGNVFVICMR PYIRSENKLY AMSIISLCCA
460 470 480 490 500
DCLMGIYLFV IGGFDLKFRG EYNKHAQLWM ESTHCQLVGS LAILSTEVSV
510 520 530 540 550
LLLTFLTLEK YICIVYPFRC VRPGKCRTIT VLILIWITGF IVAFIPLSNK
560 570 580 590 600
EFFKNYYGTN GVCFPLHSED TESIGAQVYS VAIFLGINLA AFIIIVFSYG
610 620 630 640 650
SMFYSVHQSA ITATEIRNQV KKEMILAKRF FFIVFTDALC WIPIFVVKFL
660 670 680 690 700
SLLQVEIPGT ITSWVVIFIL PINSALNPIL YTLTTRPFKE MIHRFWYNYR
710 720 730 740 750
QRKSMDSKGQ KTYAPSFIWV EMWPLQEMPP ELMKPGLFTY PCEMSLISQS

TRLNSYS
Length:757
Mass (Da):86,703
Last modified:December 21, 2004 - v1
Checksum:i140A8E16F8A6ACDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860744 mRNA. Translation: CAH92858.1.
RefSeqiNP_001126672.1. NM_001133200.1.

Genome annotation databases

GeneIDi100173672.
KEGGipon:100173672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860744 mRNA. Translation: CAH92858.1.
RefSeqiNP_001126672.1. NM_001133200.1.

3D structure databases

ProteinModelPortaliQ5R5V8.
SMRiQ5R5V8. Positions 21-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016938.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173672.
KEGGipon:100173672.

Organism-specific databases

CTDi59350.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
ENOG410Z84K. LUCA.
HOVERGENiHBG026354.
InParanoidiQ5R5V8.
KOiK04306.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXFP1_PONAB
AccessioniPrimary (citable) accession number: Q5R5V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.