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Q5R5V3 (GPD1L_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein
EC=1.1.1.8
Gene names
Name:GPD1L
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L By similarity.

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Subunit structure

Interacts with SCN5A By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Glycerol-3-phosphate dehydrogenase 1-like protein
PRO_0000286513

Regions

Nucleotide binding12 – 176NAD By similarity
Region271 – 2722Substrate binding By similarity

Sites

Active site2061Proton acceptor By similarity
Binding site431NAD By similarity
Binding site991NAD By similarity
Binding site1221Substrate By similarity
Binding site1551NAD; via amide nitrogen By similarity
Binding site2711NAD By similarity
Binding site2981NAD; via amide nitrogen By similarity
Binding site3001NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R5V3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 74C273D429C8F30D

FASTA35138,329
        10         20         30         40         50         60 
MAAAPLKVCI VGSGNWGSAV AKIIGNNVKK LQKFASTVKM WVFEETVNGR KLTDIINNDH 

        70         80         90        100        110        120 
ENVKYLPGHK LPENVVAISN LSEAVQDADL LVFVIPHQFI HRICDEITGR VPKKALGITL 

       130        140        150        160        170        180 
IKGIDEGPEG LKLISDIIRE KMGIDISVLM GANIANEVAA EKFCETTIGS KVMENGLLFK 

       190        200        210        220        230        240 
ELLQTPNFRI TVVDDADTVE LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF 

       250        260        270        280        290        300 
ARIFCKGQVS TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KEMLNGQKLQ 

       310        320        330        340        350 
GPQTSAEVYR ILKQKGLLDK FPLFTAVYQI CYESRPVQGM LSCLQSHPEH T

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR860749 mRNA. Translation: CAH92863.1.
RefSeqNP_001126675.1. NM_001133203.1.
UniGenePab.18106.

3D structure databases

HSSPHSSP built from PDB template 1X0X based on UniProtKB Q8N1B0.
ProteinModelPortalQ5R5V3.
SMRQ5R5V3. Positions 4-346.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173675.
KEGGpon:100173675.

Organism-specific databases

CTD23171.

Phylogenomic databases

HOVERGENHBG003669.
KOK00006.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPD1L_PONAB
AccessionPrimary (citable) accession number: Q5R5V3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 21, 2004
Last modified: March 6, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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