Reviewed, UniProtKB/Swiss-Prot Q5R5V3 (GPD1L_PONAB)

Names and origin

Protein names

Recommended name:
    Glycerol-3-phosphate dehydrogenase 1-like protein
    EC=1.1.1.8

Gene names

Name:

GPD1L

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Subcellular location	CytoplasmPotential.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Glycerol-3-phosphate dehydrogenase 1-like protein		PRO_0000286513
Regions
	Nucleotide binding	12 – 17	6	NAD By similarity
	Region	271 – 272	2	Substrate binding By similarity
Sites
	Active site	206	1	Proton acceptor By similarity
	Binding site	43	1	NAD By similarity
	Binding site	99	1	NAD By similarity
	Binding site	122	1	Substrate By similarity
	Binding site	155	1	NAD; via amide nitrogen By similarity
	Binding site	271	1	NAD By similarity
	Binding site	298	1	NAD; via amide nitrogen By similarity
	Binding site	300	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R5V3-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 74C273D429C8F30D	FASTA	351	38,329
	10 20 30 40 50 60 MAAAPLKVCI VGSGNWGSAV AKIIGNNVKK LQKFASTVKM WVFEETVNGR KLTDIINNDH 70 80 90 100 110 120 ENVKYLPGHK LPENVVAISN LSEAVQDADL LVFVIPHQFI HRICDEITGR VPKKALGITL 130 140 150 160 170 180 IKGIDEGPEG LKLISDIIRE KMGIDISVLM GANIANEVAA EKFCETTIGS KVMENGLLFK 190 200 210 220 230 240 ELLQTPNFRI TVVDDADTVE LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF 250 260 270 280 290 300 ARIFCKGQVS TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KEMLNGQKLQ 310 320 330 340 350 GPQTSAEVYR ILKQKGLLDK FPLFTAVYQI CYESRPVQGM LSCLQSHPEH T

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860749 mRNA. Translation: CAH92863.1.
RefSeq	NP_001126675.1.
3D structure databases
SMR	Q5R5V3. Positions 4-346.
ModBase	Search...
Genome annotation databases
GeneID	100173675.
Phylogenomic databases
HOVERGEN	Q5R5V3.
Family and domain databases
InterPro	IPR013328. DHase_multihelical. IPR016040. NAD(P)-bd. IPR017751. NAD-dep_Gly3P_DH_euk. IPR006168. NAD-dep_Gly3P_DHase. IPR011128. NAD-dep_Gly3P_DHase_N. IPR006109. NAD_Gly3P_DHase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11728. NAD_Gly3P_DH. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTS	PR00077. GPDHDRGNASE.
ProDom	PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00957. NAD_G3PDH. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD1L_PONAB

Accession

Primary (citable) accession number: Q5R5V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)