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Q5R5N6

- BGLR_PONAB

UniProt

Q5R5N6 - BGLR_PONAB

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Protein
Beta-glucuronidase
Gene
GUSB
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays an important role in the degradation of dermatan and keratan sulfates By similarity.

Catalytic activityi

A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.

Enzyme regulationi

Inhibited by L-aspartic acid By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei451 – 4511Proton donor By similarity

GO - Molecular functioni

  1. beta-glucuronidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucuronidase (EC:3.2.1.31)
Gene namesi
Name:GUSB
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 651629Beta-glucuronidase
PRO_0000231039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi631 – 6311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R5N6.
SMRiQ5R5N6. Positions 22-632.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004843.
KOiK01195.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R5N6-1 [UniParc]FASTAAdd to Basket

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MARGSAVAWA AFGPLLWGCA LGLQGGMLYP QESRSRERKE LDGLWSFRAD    50
FSDNRRRGFE EQWYRRPLRE SGPTLDMPVP SSFNDISQDW RLRHFVGWVW 100
YEREVILPER WTQDLHTRVV LRIGSAHSYA IVWVNGVDTL EHEGGYLPFE 150
ADISNLVQVG PLPSRLRITI AINNTLTPTT LPPGTIQYMN DTSKYPKGYF 200
VQNTYFDFFN YAGLQRSVLL YTTPTTYIDD ITVTTGVEQD SGLVNYQISV 250
KGSNLFELEA RLLDAENKVV ANGTGTQGQL KVPGASLWWP YLMHERPAYL 300
YSLEVRLTAQ TSLGPVSDFY SLPVGIRTVA VTESQFLING KPFYFHGVNK 350
HEDADIRGKG FDWPLLVKDF NLLRWLGANA FRTSHYPYAE EVLQMCDRHG 400
IVVIDECPGV GLALPQFFNN VSLHHHMRVM EEVVRRDKNH PAVVMWSVAN 450
EPASHLESAG YYLKMVIAHT KALDPSRPVT FVSNSNYAAD KGAPYVDVIC 500
LNSYYSWYHD YGHLELIQLQ LATQFENWYK KYQKPIIQSE YGAETIAGFH 550
QDPPLMFTEE YQKSLLEQYH LGLDQKRRKY VVGELIWNFA DFMTEQSLTR 600
VLGNKKGIFT RQRQPKSAAF LLRERYWKIA NETRYPHSVA KSQCLENSPF 650
T 651
Length:651
Mass (Da):74,772
Last modified:April 4, 2006 - v2
Checksum:iA3170629BE393917
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41G → R in CAH92009. 1 Publication
Sequence conflicti69 – 691R → Q in CAH92930. 1 Publication
Sequence conflicti370 – 3701F → I in CAH92009. 1 Publication
Sequence conflicti406 – 4061E → G in CAH92930. 1 Publication
Sequence conflicti460 – 4601G → D in CAH92009. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859852 mRNA. Translation: CAH92009.1.
CR860821 mRNA. Translation: CAH92930.1.
RefSeqiNP_001126724.1. NM_001133252.1.
NP_001128846.1. NM_001135374.1.
UniGeneiPab.18644.
Pab.8068.

Genome annotation databases

GeneIDi100173726.
100189763.
KEGGipon:100173726.
pon:100189763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859852 mRNA. Translation: CAH92009.1 .
CR860821 mRNA. Translation: CAH92930.1 .
RefSeqi NP_001126724.1. NM_001133252.1.
NP_001128846.1. NM_001135374.1.
UniGenei Pab.18644.
Pab.8068.

3D structure databases

ProteinModelPortali Q5R5N6.
SMRi Q5R5N6. Positions 22-632.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100173726.
100189763.
KEGGi pon:100173726.
pon:100189763.

Organism-specific databases

CTDi 2990.

Phylogenomic databases

HOVERGENi HBG004843.
KOi K01195.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SUPFAMi SSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex and Kidney.

Entry informationi

Entry nameiBGLR_PONAB
AccessioniPrimary (citable) accession number: Q5R5N6
Secondary accession number(s): Q5R8A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: October 16, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi