Reviewed, UniProtKB/Swiss-Prot Q5R5L3 (DJC10_PONAB)

Names and origin

Protein names

Recommended name:
    DnaJ homolog subfamily C member 10

Gene names

Name:

DNAJC10

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	793 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May be involved in disulfide formation. May act as a co-chaperone for HSPA5 By similarity.
Subunit structure	Interacts with HSPA5 via its J domain By similarity.
Subcellular location	Secreted Potential. Endoplasmic reticulum lumen By similarity.
Sequence similarities	Contains 1 J domain. Contains 4 thioredoxin domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Secreted
Domain	Repeat Signal
Molecular function	Chaperone
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 793	761	DnaJ homolog subfamily C member 10		PRO_0000281485
Regions
	Domain	35 – 100	66	J
	Domain	130 – 232	103	Thioredoxin 1
	Domain	454 – 553	100	Thioredoxin 2
	Domain	557 – 662	106	Thioredoxin 3
	Domain	671 – 778	108	Thioredoxin 4
	Motif	790 – 793	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	530	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5R5L3-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: FADC1167FC65121E	FASTA	793	90,951
	10 20 30 40 50 60 MGVWLSKDDY IRDLKRIILC FLIVYMAILV GTEQDFYSLL GVSKTASSRE IRQAFKKLAL 70 80 90 100 110 120 KLHPDKNPNN PNAHGNFLKI NRAYEVLKDE DLRKKYDKYG EKGLEDNQGG QYESWNYYRY 130 140 150 160 170 180 DFGIYDDDPE IITLERREFD AAVNSGELWF VNFYSPGCSH CHDLAPTWRD FAKEVDGLLR 190 200 210 220 230 240 IGAVNCGDDR MLCRMKGVNS YPSLFIFRSG MAPVKYHGDR SKESLVSFAM QHVRSTVTEL 250 260 270 280 290 300 WTGNFVNSIQ TAFAAGIGWL ITFCSKGGDC LTSQTRLRLS GMLDGLVNVG WMDCATQDNL 310 320 330 340 350 360 CKSLDITTST TAYFPPGATL NNKEKNSILF LNSLDAKEIY LEVIHNLPDF ELLSAHTLED 370 380 390 400 410 420 RLAHHRWLLF FHFGKNENSN DPELKKLKTL LKNDHIQVGR FDCSSAPDIC SNLYVFQPSL 430 440 450 460 470 480 AVFKGQGTKE YEIHHGKKIL YDILAFAKES VNSHVTTLGP QNFPANDKEP WLVDFFAPWC 490 500 510 520 530 540 PPCRALLPEL RRASNLLYGQ LKFGTLDCTV HEGLCNMYNI QAYPTTVVFN QSNIHEYEGH 550 560 570 580 590 600 HSAEQILEFI EDLMNPSVVS LTPTTFNELV TQRKHNEVWM VDFYSPWCHP CQVLMPEWKR 610 620 630 640 650 660 MARTLTGLIN VGSIDCQQYH SFCAQENVQR YPEIRFFPPK SNKAYQYHSY NGWNRDAYSL 670 680 690 700 710 720 RIWGLGFLPQ VSTGLTPQTF SEKVLQGKNH WVIDFYAPWC GPCQNFAPEF ELLARMIKGK 730 740 750 760 770 780 VKAGKVDCQA YAQTCQKAGI RAYPTVKFYF YESAKRTFQE EQINIRDAKA IAALINEKLE 790 TLQNQGKRNK DEL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860844 mRNA. Translation: CAH92953.1.
RefSeq	NP_001126740.1.
UniGene	Pab.5348
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100173742.
Phylogenomic databases
HOVERGEN	Q5R5L3.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR000886. ER_targeting_sequence. IPR018253. Heat_shock_DnaJ_CS. IPR015609. Hsp40/DnaJ_Rel. IPR003095. Hsp_DnaJ. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 4 hits.
PANTHER	PTHR11821. Hsp40/DnaJ_Rel. 1 hit.
Pfam	PF00226. DnaJ. 1 hit. PF00085. Thioredoxin. 4 hits. [Graphical view]
PRINTS	PR00625. DNAJPROTEIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
PROSITE	PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 2 hits. PS51352. THIOREDOXIN_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DJC10_PONAB

Accession

Primary (citable) accession number: Q5R5L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	December 21, 2004
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)