Calcium-transporting ATPase type 2C member 1 - Pongo abelii (Sumatran orangutan)

Contribute

Send feedback

Read comments (?) or add your own

Q5R5K5 (AT2C1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 56. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Calcium-transporting ATPase type 2C member 1
Short name=ATPase 2C1
EC=3.6.3.8

Gene names

Name:

ATP2C1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	918 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium By similarity.
Catalytic activity	ATP + H₂O + Ca²⁺(Side 1) = ADP + phosphate + Ca²⁺(Side 2).
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi calcium ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB Golgi calcium ion transport Inferred from sequence or structural similarity. Source: UniProtKB actin cytoskeleton reorganization Inferred from sequence or structural similarity. Source: UniProtKB calcium-dependent cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cellular manganese ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB epidermis development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW trans-Golgi network Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB calcium-transporting ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB manganese ion binding Inferred from sequence or structural similarity. Source: UniProtKB manganese-transporting ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB signal transducer activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 918

918

Calcium-transporting ATPase type 2C member 1

PRO_0000326150

Regions

Topological domain

1 – 75

Cytoplasmic Potential

Transmembrane

76 – 96

Helical; Potential

Topological domain

97 – 98

Extracellular Potential

Transmembrane

99 – 119

Helical; Potential

Topological domain

120 – 267

148

Cytoplasmic Potential

Transmembrane

268 – 288

Helical; Potential

Topological domain

289 – 302

Extracellular Potential

Transmembrane

303 – 323

Helical; Potential

Topological domain

324 – 703

380

Cytoplasmic Potential

Transmembrane

704 – 724

Helical; Potential

Topological domain

725 – 732

Extracellular Potential

Transmembrane

733 – 753

Helical; Potential

Topological domain

754 – 773

Cytoplasmic Potential

Transmembrane

774 – 794

Helical; Potential

Topological domain

795 – 842

Extracellular Potential

Transmembrane

843 – 863

Helical; Potential

Topological domain

864 – 873

Cytoplasmic Potential

Transmembrane

874 – 894

Helical; Potential

Topological domain

895 – 918

Extracellular Potential

Sites

Active site

350

4-aspartylphosphate intermediate By similarity

Metal binding

643

Magnesium By similarity

Metal binding

647

Magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q5R5K5 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 96C2EE903944AD83
Show »

FASTA

918

100,400

        10         20         30         40         50         60 
MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE VSHRRAFHGW 

        70         80         90        100        110        120 
NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF DDAVSITVAI LIVVTVAFVQ 

       130        140        150        160        170        180 
EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 

       190        200        210        220        230        240 
LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE 

       250        260        270        280        290        300 
FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 

       310        320        330        340        350        360 
LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 

       370        380        390        400        410        420 
TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 

       430        440        450        460        470        480 
LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 

       490        500        510        520        530        540 
GAYEQVIKYC TTYQSKGQTL TLTQQQRDVQ QEKARMGSAG LRVLALASGP ELGQLTFLGL 

       550        560        570        580        590        600 
VGIIDPPRTG VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEIDA 

       610        620        630        640        650        660 
MDVQQLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGSVVAM TGDGVNDAVA LKAADIGVAM 

       670        680        690        700        710        720 
GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN FVRFQLSTSI AALTLISLAT 

       730        740        750        760        770        780 
LMNFPNPLNA MQILWINIIM DGPPAQSLGV EPVDKDVIRK PPRNWKDSIL TKNLILKILV 

       790        800        810        820        830        840 
SSIIIVCGTL FVFWRELRDN VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN 

       850        860        870        880        890        900 
KMFCYAVLGS IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV AEIIKKVERS 

       910 
REKIQKHVSS TSSSFLEV

« Hide

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860853 mRNA. Translation: CAH92961.1.
UniGene	Pab.18630.
3D structure databases
HSSP	HSSP built from PDB template 1WPG based on UniProtKB P04191.
ProteinModelPortal	Q5R5K5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000265621.
HOVERGEN	HBG106478.
InParanoid	Q5R5K5.
Family and domain databases
Gene3D	1.20.1110.10. 3 hits.
InterPro	IPR006413. ATPase_P-typ_Ca-transp_PMR1. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01522. ATPase-IIA2_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT2C1_PONAB

Accession

Primary (citable) accession number: Q5R5K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents