Calcium-transporting ATPase type 2C member 1 - Pongo abelii (Sumatran orangutan)

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Reviewed, UniProtKB/Swiss-Prot Q5R5K5 (AT2C1_PONAB)

Last modified October 13, 2009. Version 34. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Calcium-transporting ATPase type 2C member 1
      Short name=ATPase 2C1
    EC=3.6.3.8

Gene names

Name:

ATP2C1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length	918 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium By similarity.
Catalytic activity	ATP + H₂O + Ca²⁺(Cis) = ADP + phosphate + Ca²⁺(Trans).
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily.

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane
Ligand	ATP-binding Calcium Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro Golgi calcium ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB Golgi calcium ion transport Inferred from sequence or structural similarity. Source: UniProtKB actin cytoskeleton reorganization Inferred from sequence or structural similarity. Source: UniProtKB calcium-dependent cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cellular manganese ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB epidermis development Inferred from sequence or structural similarity. Source: UniProtKB manganese ion transport Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	Golgi membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB calcium-transporting ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from sequence or structural similarity. Source: UniProtKB manganese-transporting ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB signal transducer activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 918

918

Calcium-transporting ATPase type 2C member 1

PRO_0000326150

Regions

Topological domain

1 – 75

Cytoplasmic Potential

Transmembrane

76 – 96

Potential

Topological domain

97 – 98

Extracellular Potential

Transmembrane

99 – 119

Potential

Topological domain

120 – 267

148

Cytoplasmic Potential

Transmembrane

268 – 288

Potential

Topological domain

289 – 302

Extracellular Potential

Transmembrane

303 – 323

Potential

Topological domain

324 – 703

380

Cytoplasmic Potential

Transmembrane

704 – 724

Potential

Topological domain

725 – 732

Extracellular Potential

Transmembrane

733 – 753

Potential

Topological domain

754 – 773

Cytoplasmic Potential

Transmembrane

774 – 794

Potential

Topological domain

795 – 842

Extracellular Potential

Transmembrane

843 – 863

Potential

Topological domain

864 – 873

Cytoplasmic Potential

Transmembrane

874 – 894

Potential

Topological domain

895 – 918

Extracellular Potential

Sites

Active site

350

4-aspartylphosphate intermediate By similarity

Metal binding

643

Magnesium By similarity

Metal binding

647

Magnesium By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q5R5K5-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 96C2EE903944AD83
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FASTA

918

100,400

        10         20         30         40         50         60 
MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE VSHRRAFHGW 

        70         80         90        100        110        120 
NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF DDAVSITVAI LIVVTVAFVQ 

       130        140        150        160        170        180 
EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 

       190        200        210        220        230        240 
LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE 

       250        260        270        280        290        300 
FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 

       310        320        330        340        350        360 
LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 

       370        380        390        400        410        420 
TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 

       430        440        450        460        470        480 
LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 

       490        500        510        520        530        540 
GAYEQVIKYC TTYQSKGQTL TLTQQQRDVQ QEKARMGSAG LRVLALASGP ELGQLTFLGL 

       550        560        570        580        590        600 
VGIIDPPRTG VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEIDA 

       610        620        630        640        650        660 
MDVQQLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGSVVAM TGDGVNDAVA LKAADIGVAM 

       670        680        690        700        710        720 
GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN FVRFQLSTSI AALTLISLAT 

       730        740        750        760        770        780 
LMNFPNPLNA MQILWINIIM DGPPAQSLGV EPVDKDVIRK PPRNWKDSIL TKNLILKILV 

       790        800        810        820        830        840 
SSIIIVCGTL FVFWRELRDN VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN 

       850        860        870        880        890        900 
KMFCYAVLGS IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV AEIIKKVERS 

       910 
REKIQKHVSS TSSSFLEV

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References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

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Cross-references

Sequence databases
	CR860853 mRNA. Translation: CAH92961.1.
UniGene	Pab.18630
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q5R5K5.
Enzyme and pathway databases
BRENDA	3.6.3.8. 269192.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006413. ATPase_P-typ_Ca-transp_PMR1. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
TIGRFAMs	TIGR01522. ATPase-IIA2_Ca. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

AT2C1_PONAB

Accession

Primary (citable) accession number: Q5R5K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 21, 2004
Last modified:	October 13, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents