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Reviewed, UniProtKB/Swiss-Prot Q5R5J5 (DHDH_PONAB)

Last modified September 1, 2009. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    EC=1.3.1.20
Alternative name(s):
    Dimeric dihydrodiol dehydrogenase
    D-xylose-NADP dehydrogenase
    EC=1.1.1.179
    D-xylose 1-dehydrogenase
Gene names
Name: DHDH
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the gfo/idh/mocA family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
PRO_0000315366

Sites

Site711May play an important role in coenzyme binding By similarity
Site791May play an important role in coenzyme binding By similarity
Site971May play an important role in coenzyme binding By similarity
Site1761May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
Site1801May play an important role in catalytic activity By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5R5J5-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 13FCCA0EAE897B4B

FASTA33436,437
        10         20         30         40         50         60 
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEVAEKHD IPKAYGSYEE 

        70         80         90        100        110        120 
LAKDPNVEVA YIGTQHPQHK AAVMLCLAAG EAVLCEKPMG VNVAEVREMV AEARSRDLFL 

       130        140        150        160        170        180 
MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLTH IPRAIDWAQA GGALLDIGIY 

       190        200        210        220        230        240 
CVQFISMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TAQLSNTASV 

       250        260        270        280        290        300 
SGTKGMAQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVRECLRKGM 

       310        320        330 
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR

« Hide

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

CR860863 mRNA. Translation: CAH92971.1.
RefSeqNP_001127612.1.
UniGenePab.18175

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID100174691.

Organism-specific databases

CTD100174691.

Phylogenomic databases

HOVERGENQ5R5J5.

Enzyme and pathway databases

BRENDA1.1.1.179. 269192.
1.3.1.20. 269192.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDHDH_PONAB
AccessionPrimary (citable) accession number: Q5R5J5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: September 1, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents