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Q5R5F3 (DHSO_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sorbitol dehydrogenase

EC=1.1.1.14
Alternative name(s):
L-iditol 2-dehydrogenase
Gene names
Name:SORD
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm By similarity.

Catalytic activity

L-iditol + NAD+ = L-sorbose + NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion membrane; Peripheral membrane protein. Cell projectionciliumflagellum. Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 357356Sorbitol dehydrogenase
PRO_0000301685

Sites

Metal binding451Zinc; catalytic By similarity
Metal binding701Zinc; catalytic By similarity
Metal binding711Zinc; catalytic By similarity
Binding site511Substrate By similarity
Binding site1561Substrate By similarity
Binding site2991Substrate By similarity
Binding site3001Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R5F3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 630FB00DE09BC886

FASTA35738,212
        10         20         30         40         50         60 
MAAAAKPSNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEDGRIGNF 

        70         80         90        100        110        120 
IVKKPMVLGH EASGTVEKVG SLVKHLKPGD RVAIEPGAPR ENDEFCKIGR YNLSPSIFFC 

       130        140        150        160        170        180 
ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGAMIEPLSV GIHACRRGGV TLGHKVLVCG 

       190        200        210        220        230        240 
AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGLL 

       250        260        270        280        290        300 
GCKPEVTIEC TGAGASIQAG IYATHSGGTL VLVGLGSEMT TIPLLHAAIR EVDIKGVFRY 

       310        320        330        340        350 
CNTWPVAISM LASKSVNVKP LITHRFPLEK ALEAFETFKK GLGLKIMLKC DPNDQNP 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860908 mRNA. Translation: CAH93013.1.
RefSeqNP_001126780.1. NM_001133308.1.
UniGenePab.18242.

3D structure databases

HSSPHSSP built from PDB template 1PL8 based on UniProtKB Q00796.
ProteinModelPortalQ5R5F3.
SMRQ5R5F3. Positions 2-357.
ModBaseSearch...

Proteomic databases

PRIDEQ5R5F3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173784.
KEGGpon:100173784.

Organism-specific databases

CTD6652.

Phylogenomic databases

HOVERGENHBG005484.
InParanoidQ5R5F3.
KOK00008.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHSO_PONAB
AccessionPrimary (citable) accession number: Q5R5F3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families