Reviewed, UniProtKB/Swiss-Prot Q5R5F3 (DHSO_PONAB)

Names and origin

Protein names

Recommended name:
    Sorbitol dehydrogenase
    EC=1.1.1.14
Alternative name(s):
    L-iditol 2-dehydrogenase

Gene names

Name:

SORD

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-iditol + NAD(+) = L-sorbose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Molecular function	L-iditol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 357	356	Sorbitol dehydrogenase		PRO_0000301685
Sites
	Metal binding	45	1	Zinc; catalytic By similarity
	Metal binding	70	1	Zinc; catalytic By similarity
	Metal binding	71	1	Zinc; catalytic By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R5F3-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 630FB00DE09BC886	FASTA	357	38,212
	10 20 30 40 50 60 MAAAAKPSNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEDGRIGNF 70 80 90 100 110 120 IVKKPMVLGH EASGTVEKVG SLVKHLKPGD RVAIEPGAPR ENDEFCKIGR YNLSPSIFFC 130 140 150 160 170 180 ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGAMIEPLSV GIHACRRGGV TLGHKVLVCG 190 200 210 220 230 240 AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGLL 250 260 270 280 290 300 GCKPEVTIEC TGAGASIQAG IYATHSGGTL VLVGLGSEMT TIPLLHAAIR EVDIKGVFRY 310 320 330 340 350 CNTWPVAISM LASKSVNVKP LITHRFPLEK ALEAFETFKK GLGLKIMLKC DPNDQNP

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860908 mRNA. Translation: CAH93013.1.
RefSeq	NP_001126780.1.
3D structure databases
SMR	Q5R5F3. Positions 2-357.
ModBase	Search...
Genome annotation databases
GeneID	100173784.
Phylogenomic databases
HOVERGEN	Q5R5F3.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSO_PONAB

Accession

Primary (citable) accession number: Q5R5F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)