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Protein

3-hydroxyisobutyrate dehydrogenase, mitochondrial

Gene

HIBADH

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108NADBy similarity1
Binding sitei134NAD; via amide nitrogenBy similarity1
Active sitei209By similarity1
Binding sitei284NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 69NADBy similarityAdd BLAST30
Nucleotide bindingi103 – 104NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processBranched-chain amino acid catabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00362

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyrate dehydrogenase, mitochondrial (EC:1.1.1.31)
Short name:
HIBADH
Gene namesi
Name:HIBADH
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 36MitochondrionBy similarityAdd BLAST36
ChainiPRO_000029034137 – 3363-hydroxyisobutyrate dehydrogenase, mitochondrialAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60N6-acetyllysine; alternateBy similarity1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei76N6-acetyllysine; alternateBy similarity1
Modified residuei76N6-succinyllysine; alternateBy similarity1
Modified residuei95N6-succinyllysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1
Modified residuei141N6-succinyllysineBy similarity1
Modified residuei145N6-acetyllysineBy similarity1
Modified residuei149N6-acetyllysine; alternateBy similarity1
Modified residuei149N6-succinyllysine; alternateBy similarity1
Modified residuei238N6-acetyllysine; alternateBy similarity1
Modified residuei238N6-succinyllysine; alternateBy similarity1
Modified residuei242N6-acetyllysine; alternateBy similarity1
Modified residuei242N6-succinyllysine; alternateBy similarity1
Modified residuei297N6-succinyllysineBy similarity1
Modified residuei321N6-acetyllysine; alternateBy similarity1
Modified residuei321N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ5R5E7

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000019832

Structurei

3D structure databases

ProteinModelPortaliQ5R5E7
SMRiQ5R5E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0409 Eukaryota
COG2084 LUCA
GeneTreeiENSGT00530000063270
HOVERGENiHBG050424
InParanoidiQ5R5E7
OMAiWPSEVNN
OrthoDBiEOG091G0CUJ
TreeFamiTF314043

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006115 6PGDH_NADP-bd
IPR011548 HIBADH
IPR015815 HIBADH-related
IPR036291 NAD(P)-bd_dom_sf
IPR029154 NADP-bd
PfamiView protein in Pfam
PF14833 NAD_binding_11, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000103 HIBADH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01692 HIBADH, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R5E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLRLLGA ASGLRYWSRR LRPAAGSFAA VCSRSVASKT PVGFIGLGNM
60 70 80 90 100
GNPMAKNLMK HGYPLIIYDV FPDACKEFQD AGEQVVSSPA DVAEKADRII
110 120 130 140 150
TMLPTSINAI EAYSGANGIL KKVKKGSLLI DSSTIDPAVS KELAKEVEKM
160 170 180 190 200
GAVFMDAPVS GGVGAARSGN LTFMVGGVED EFAAAQELLG CMGSNVVYCG
210 220 230 240 250
AVGTGQAAKI CNNMLLAISM IGTAEAMNLG IRLGLDPKLL AKILNMSSGR
260 270 280 290 300
CWSSDTYNPV PGVMDGVPSA NNYQGGFGAT LMAKDLGLAQ DSATSTKSPI
310 320 330
LLGSLAHQIY RMMCAKGYSK KDFSSVFQFL REEETF
Length:336
Mass (Da):35,299
Last modified:December 21, 2004 - v1
Checksum:iDA243D775F84AF48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860914 mRNA Translation: CAH93019.1
RefSeqiNP_001127621.1, NM_001134149.1
XP_009241202.1, XM_009242927.1
UniGeneiPab.18605

Genome annotation databases

EnsembliENSPPYT00000020615; ENSPPYP00000019832; ENSPPYG00000017693
GeneIDi100174700
100189883
KEGGipon:100174700

Similar proteinsi

Entry informationi

Entry namei3HIDH_PONAB
AccessioniPrimary (citable) accession number: Q5R5E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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