Reviewed, UniProtKB/Swiss-Prot Q5R5D8 (BODG_PONAB)

Names and origin

Protein names

Recommended name:
    Gamma-butyrobetaine dioxygenase
    EC=1.14.11.1
Alternative name(s):
    Gamma-butyrobetaine,2-oxoglutarate dioxygenase
    Gamma-butyrobetaine hydroxylase
      Short name=Gamma-BBH

Gene names

Name:

BBOX1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of L-carnitine from gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.
Cofactor	Iron By similarity. Ascorbate By similarity.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-BBH/TMLD family.

Ontologies

Keywords
Biological process	Carnitine biosynthesis
Cellular component	Cytoplasm
Ligand	Iron
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	carnitine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro gamma-butyrobetaine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Gamma-butyrobetaine dioxygenase		PRO_0000260155

Sequences

	Sequence		Length	Mass (Da)
	Q5R5D8-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 348C64E21A8BB0D5	FASTA	387	44,660
	10 20 30 40 50 60 MACTIQKAEA LDGARLMQIL WYDEEESLYP AVWLRDNCPC SDCYLDSAKA RKLLAEALDV 70 80 90 100 110 120 NIGIKGLTFD RKKVYITWPD EHYSEFQADW LKKRCLSKQA RAKLQRELFF PECQYWGSEL 130 140 150 160 170 180 QLPTLDFEDV LRYDEHAYKW LSTLKKVGIV RLTGASDKPG EVSKLGKRMG FLYLTFYGHT 190 200 210 220 230 240 WQVQDKIDAN NVAYTTGKLS FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK 250 260 270 280 290 300 LKKNNPQAFQ ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRIN FNNATRDTIF 310 320 330 340 350 360 DVPVERVQPF YAALKEFVDL MNSKESKFTF KMNPGDVITF DNWRLLHGRR SYEAGTEISR 370 380 HLEGAYADWD VVMSRLRILR QRVENGN

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860924 mRNA. Translation: CAH93028.1.
RefSeq	NP_001126790.1.
UniGene	Pab.18602
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100173794.
Phylogenomic databases
HOVERGEN	Q5R5D8.
Enzyme and pathway databases
BRENDA	1.14.11.1. 269192.
Family and domain databases
InterPro	IPR012775. 2-oxoglut_dOase. IPR003819. Taurine_dOase. [Graphical view]
Pfam	PF02668. TauD. 1 hit. [Graphical view]
TIGRFAMs	TIGR02409. carnitine_bodg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BODG_PONAB

Accession

Primary (citable) accession number: Q5R5D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	December 21, 2004
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)