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Protein

Gamma-butyrobetaine dioxygenase

Gene

BBOX1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of L-carnitine from gamma-butyrobetaine.By similarity

Catalytic activityi

4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.

Cofactori

Protein has several cofactor binding sites:
  • Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
  • L-ascorbateBy similarity

Pathwayi: carnitine biosynthesis

This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38ZincBy similarity1
Metal bindingi40ZincBy similarity1
Metal bindingi43ZincBy similarity1
Metal bindingi82ZincBy similarity1
Metal bindingi202Iron; catalyticBy similarity1
Metal bindingi204Iron; catalyticBy similarity1
Metal bindingi347Iron; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Carnitine biosynthesis

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00118.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-butyrobetaine dioxygenase (EC:1.14.11.1)
Alternative name(s):
Gamma-butyrobetaine hydroxylase
Short name:
Gamma-BBH
Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Gene namesi
Name:BBOX1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002601551 – 387Gamma-butyrobetaine dioxygenaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000003911.

Structurei

3D structure databases

ProteinModelPortaliQ5R5D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-BBH/TMLD family.Curated

Phylogenomic databases

eggNOGiKOG3888. Eukaryota.
COG2175. LUCA.
HOVERGENiHBG031125.
InParanoidiQ5R5D8.
KOiK00471.

Family and domain databases

InterProiIPR010376. DUF971.
IPR012775. GBBH.
IPR003819. TauD/TfdA-like.
[Graphical view]
PfamiPF06155. DUF971. 1 hit.
PF02668. TauD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02409. carnitine_bodg. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R5D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACTIQKAEA LDGARLMQIL WYDEEESLYP AVWLRDNCPC SDCYLDSAKA
60 70 80 90 100
RKLLAEALDV NIGIKGLTFD RKKVYITWPD EHYSEFQADW LKKRCLSKQA
110 120 130 140 150
RAKLQRELFF PECQYWGSEL QLPTLDFEDV LRYDEHAYKW LSTLKKVGIV
160 170 180 190 200
RLTGASDKPG EVSKLGKRMG FLYLTFYGHT WQVQDKIDAN NVAYTTGKLS
210 220 230 240 250
FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK LKKNNPQAFQ
260 270 280 290 300
ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRIN FNNATRDTIF
310 320 330 340 350
DVPVERVQPF YAALKEFVDL MNSKESKFTF KMNPGDVITF DNWRLLHGRR
360 370 380
SYEAGTEISR HLEGAYADWD VVMSRLRILR QRVENGN
Length:387
Mass (Da):44,660
Last modified:December 21, 2004 - v1
Checksum:i348C64E21A8BB0D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860924 mRNA. Translation: CAH93028.1.
RefSeqiNP_001126790.1. NM_001133318.1.

Genome annotation databases

GeneIDi100173794.
KEGGipon:100173794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860924 mRNA. Translation: CAH93028.1.
RefSeqiNP_001126790.1. NM_001133318.1.

3D structure databases

ProteinModelPortaliQ5R5D8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000003911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173794.
KEGGipon:100173794.

Organism-specific databases

CTDi8424.

Phylogenomic databases

eggNOGiKOG3888. Eukaryota.
COG2175. LUCA.
HOVERGENiHBG031125.
InParanoidiQ5R5D8.
KOiK00471.

Enzyme and pathway databases

UniPathwayiUPA00118.

Family and domain databases

InterProiIPR010376. DUF971.
IPR012775. GBBH.
IPR003819. TauD/TfdA-like.
[Graphical view]
PfamiPF06155. DUF971. 1 hit.
PF02668. TauD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02409. carnitine_bodg. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBODG_PONAB
AccessioniPrimary (citable) accession number: Q5R5D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 21, 2004
Last modified: February 17, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.