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Q5R5D5 (AK1A1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase [NADP(+)]

EC=1.1.1.2
Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1
Gene names
Name:AKR1A1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.

Catalytic activity

An alcohol + NADP+ = an aldehyde + NADPH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionalcohol dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 325324Alcohol dehydrogenase [NADP(+)]
PRO_0000384150

Regions

Nucleotide binding211 – 27363NADP By similarity

Sites

Active site501Proton donor By similarity
Binding site1131Substrate By similarity
Site801Lowers pKa of active site Tyr By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1271N6-acetyllysine; alternate By similarity
Modified residue1271N6-succinyllysine; alternate By similarity
Modified residue1451N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R5D5 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 11FD0210C3B99455

FASTA32536,390
        10         20         30         40         50         60 
MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL 

        70         80         90        100        110        120 
KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALQKTLA DLQLEYLDLY LMHWPYAFER 

       130        140        150        160        170        180 
GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVRALG LSNFNSRQID DILSVASVRP 

       190        200        210        220        230        240 
AVLQVECHPY LAQNELIAHC QARGLAVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK 

       250        260        270        280        290        300 
YGGSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRHIV 

       310        320 
PMLTVDGKRV PRDAGHPLYP FNDPY 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860927 mRNA. Translation: CAH93031.1.
RefSeqNP_001126792.1. NM_001133320.1.
UniGenePab.4743.

3D structure databases

ProteinModelPortalQ5R5D5.
SMRQ5R5D5. Positions 2-325.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R5D5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173796.
KEGGpon:100173796.

Organism-specific databases

CTD10327.

Phylogenomic databases

HOGENOMHOG000250272.
InParanoidQ5R5D5.
KOK00002.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAK1A1_PONAB
AccessionPrimary (citable) accession number: Q5R5D5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: December 21, 2004
Last modified: March 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families