Reviewed, UniProtKB/Swiss-Prot Q5R5C9 (SCPDH_PONAB)

Names and origin

Protein names

Recommended name:
    Probable saccharopine dehydrogenase
    EC=1.5.1.9

Gene names

Name:

SCCPDH

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH.
Pathway	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.
Sequence similarities	Belongs to the saccharopine dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 429	428	Probable saccharopine dehydrogenase		PRO_0000212842
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R5C9-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 8263DD73C0DAD79B	FASTA	429	47,104
	10 20 30 40 50 60 MATEQRPFHL VVFGASGFTG QFVTEEVARE QVDPERSSRL PWAVAGRSRE KLQRVLEKAA 70 80 90 100 110 120 LKLGRPTLSS EVGIIICDIA NPASLDEMAK QATVVPNCVG PYRFYGEPVI KACIENGASC 130 140 150 160 170 180 IDISGEPQFL ELMQLKYHEK AADKGVYIIG SSGFDSIPAD LGVIYTRNKM NGTLTAVESF 190 200 210 220 230 240 LTIHSGPEGL SIHDGTWKSA IYGFGDQSNL RKLRNASNLK PVPLVGPKLK RRWPISYCRE 250 260 270 280 290 300 LKGYSIPFMG SDVSVVRRTQ RYLYENLEES PVQYAAYATV GGITSVIKLM FAGLFFLFFV 310 320 330 340 350 360 RFGIGRQLLI KFPWFFSFGY FSKQGPTQKQ IDAASFTLTF FGQGYSQGIG TDKNKPNIKI 370 380 390 400 410 420 CTQVKGPEAG YVATPIAMVQ AAMTLLNDAS HLPKAGGVFT PGAAFSKTKL IDRLNKHGIE FSVISSSEV

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR860933 mRNA. Translation: CAH93037.1.
RefSeq	NP_001126796.1.
UniGene	Pab.8451
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100173800.
Organism-specific databases
CTD	100173800.
Phylogenomic databases
HOVERGEN	Q5R5C9.
InParanoid	Q5R5C9.
Enzyme and pathway databases
BRENDA	1.5.1.9. 269192.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR005097. Saccharopine_DH/HSpermid_syn. [Graphical view]
Pfam	PF03435. Saccharop_dh. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCPDH_PONAB

Accession

Primary (citable) accession number: Q5R5C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	December 21, 2004
Last modified:	February 9, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)