Reviewed, UniProtKB/Swiss-Prot Q5R5A0 (ANXA2_PONAB)

Names and origin

Protein names

Recommended name:
    Annexin A2
Alternative name(s):
    Annexin-2

Gene names

Name:	ANXA2
Synonyms:	ANX2

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity By similarity.
Subunit structure	Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix › basement membrane. Note: In the lamina beneath the plasma membrane By similarity.
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Miscellaneous	It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.

Ontologies

Keywords
Cellular component	Basement membrane Extracellular matrix Secreted
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Cellular component	basement membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-dependent phospholipid binding Inferred from electronic annotation. Source: UniProtKB-KW cytoskeletal protein binding Inferred from electronic annotation. Source: InterPro phospholipase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 339	338	Annexin A2		PRO_0000288686
Regions
	Repeat	42 – 102	61	Annexin 1
	Repeat	114 – 174	61	Annexin 2
	Repeat	199 – 259	61	Annexin 3
	Repeat	274 – 334	61	Annexin 4
	Region	2 – 24	23	S100A10-binding site Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	18	1	Phosphoserine By similarity
	Modified residue	19	1	Phosphothreonine By similarity
	Modified residue	24	1	Phosphotyrosine; by SRC By similarity
	Modified residue	26	1	Phosphoserine; by PKC By similarity
	Modified residue	30	1	Phosphotyrosine By similarity
	Modified residue	104	1	N6-acetyllysine By similarity
	Modified residue	115	1	N6-acetyllysine By similarity
	Modified residue	148	1	N6-acetyllysine By similarity
	Modified residue	152	1	N6-acetyllysine By similarity
	Modified residue	157	1	N6-acetyllysine By similarity
	Modified residue	188	1	Phosphotyrosine By similarity
	Modified residue	199	1	Phosphotyrosine By similarity
	Modified residue	227	1	N6-acetyllysine By similarity
	Modified residue	238	1	Phosphotyrosine By similarity
	Modified residue	275	1	Phosphotyrosine By similarity
	Modified residue	279	1	N6-acetyllysine By similarity
	Modified residue	302	1	N6-acetyllysine By similarity
	Modified residue	313	1	N6-acetyllysine By similarity
	Modified residue	316	1	Phosphotyrosine By similarity
	Modified residue	317	1	Phosphotyrosine By similarity
	Modified residue	318	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R5A0-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 5126E1337A0CBEA1	FASTA	339	38,604
	10 20 30 40 50 60 MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL 70 80 90 100 110 120 TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 130 140 150 160 170 180 LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 190 200 210 220 230 240 EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM 250 260 270 280 290 300 LESIRKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 310 320 330 LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Web resources

Protein Spotlight

Red velvet - Issue 86 of September 2007

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR860964 mRNA. Translation: CAH93066.1.
RefSeq	NP_001126816.1.
UniGene	Pab.8142
3D structure databases
HSSP	HSSP built from PDB template 1W7B based on UniProtKB P07355.
SMR	Q5R5A0. Positions 21-339.
ModBase	Search...
Genome annotation databases
GeneID	100173821.
Organism-specific databases
CTD	100173821.
Phylogenomic databases
HOVERGEN	Q5R5A0.
OMA	CHLQKVF
Family and domain databases
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR002389. AnnexinII. [Graphical view]
Gene3D	G3DSA:1.10.220.10. Annexin. 4 hits.
PANTHER	PTHR10502. Annexin. 1 hit. PTHR10502:SF18. AnnexinII. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR00198. ANNEXINII.
SMART	SM00335. ANX. 4 hits. [Graphical view]
PROSITE	PS00223. ANNEXIN. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANXA2_PONAB

Accession

Primary (citable) accession number: Q5R5A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	December 21, 2004
Last modified:	November 24, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)