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Q5R574 (MSMO1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylsterol monooxygenase 1

EC=1.14.13.72
Alternative name(s):
C-4 methylsterol oxidase
Gene names
Name:MSMO1
Synonyms:SC4MOL
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)+ + H2O.

4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O2 = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)+ + 2 H2O.

3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O2 = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)+ + H2O.

Cofactor

Iron Probable.

Pathway

Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding By similarity.

Sequence similarities

Belongs to the sterol desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Methylsterol monooxygenase 1
PRO_0000117035

Regions

Transmembrane55 – 7521Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane199 – 21921Helical; Potential
Motif157 – 1615Histidine box-1 By similarity
Motif170 – 1745Histidine box-2 By similarity
Motif249 – 2557Histidine box-3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R574 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: D88E0DDBE85DE0BF

FASTA29335,216
        10         20         30         40         50         60 
MATNESVSIF SSASLAVEYV DSLLPENPLQ EPFKNAWNYM LNNYTKFQIA TWGSLIVHEA 

        70         80         90        100        110        120 
LYFLFCLPGF LFQFIPYMKK YKIQKDKPET WENQWKCFKV LLFNHFCIQL PLICGTYYFT 

       130        140        150        160        170        180 
EYFNIPYDWE RMPRWYFLLA RCFGCAVIED TWHYFLHRLL HHKRIYKYIH KVHHEFQAPF 

       190        200        210        220        230        240 
GMEAEYAHPL ETLILGTGFF IGIVLLCDHV ILLWAWVTIR LLETIDVHSG YDIPLNPLNL 

       250        260        270        280        290 
IPFYAGSRHH DFHHMNFIGN YASTFTWWDR IFGTDSQYNA YNEKRKKFEK KTE 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR860990 mRNA. Translation: CAH93092.1.
RefSeqNP_001126831.1. NM_001133359.1.
UniGenePab.18577.

3D structure databases

ProteinModelPortalQ5R574.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000017646; ENSPPYP00000016960; ENSPPYG00000015178.
GeneID100173838.
KEGGpon:100173838.

Organism-specific databases

CTD6307.

Phylogenomic databases

HOVERGENHBG051504.
InParanoidQ5R574.
OMAAWNYMLD.

Family and domain databases

InterProIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
KOK07750.
PfamPF04116. FA_hydroxylase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMSMO1_PONAB
AccessionPrimary (citable) accession number: Q5R574
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families