Q5R533 (SERC3_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine incorporator 3

Gene names

Name:

SERINC3

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in cellular transformation By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein By similarity.
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the TDE1 family.

Ontologies

Keywords
Cellular component	Cell membrane Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	induction of apoptosis Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Serine incorporator 3		PRO_0000342159
Regions
	Topological domain	1 – 96	96	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Topological domain	118 – 132	15	Cytoplasmic Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Topological domain	154 – 159	6	Extracellular Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Topological domain	181 – 203	23	Cytoplasmic Potential
	Transmembrane	204 – 224	21	Helical; Potential
	Topological domain	225 – 239	15	Extracellular Potential
	Transmembrane	240 – 260	21	Helical; Potential
	Topological domain	261 – 329	69	Cytoplasmic Potential
	Transmembrane	330 – 350	21	Helical; Potential
	Topological domain	351 – 406	56	Extracellular Potential
	Transmembrane	407 – 427	21	Helical; Potential
	Topological domain	428 – 446	19	Cytoplasmic Potential
	Transmembrane	447 – 467	21	Helical; Potential
	Topological domain	468 – 473	6	Extracellular Potential
Amino acid modifications
	Modified residue	371	1	Phosphoserine By similarity
	Glycosylation	34	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5R533 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 66919A8FCAC3333F	FASTA	473	52,550
	10 20 30 40 50 60 MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST VVSYIMQRKE 70 80 90 100 110 120 METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR ISFAMAIFFF VFSLLMFKVK 130 140 150 160 170 180 TSKDPRAAVH NGFWFFKIAA LIGIMVGSFY IPGGYFSSVW FVVGMIGAAL FILIQLVLLV 190 200 210 220 230 240 DFAHSWNESW VNRMEEGNPR LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF 250 260 270 280 290 300 ISINLILCVV ASIISIHPKI QEHQPRSGLL QSSVITLYTM YLTWSAMSNE PDRSCNPNLM 310 320 330 340 350 360 SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY SSIRTSTNSQ 370 380 390 400 410 420 VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG VQYSYSLFHL MLCLASLYIM 430 440 450 460 470 MTLTSWYSPD AKFQSMTSKW PAVWVKISSS WVCLLLYVWT LVAPLVLTSR DFS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR861044 mRNA. Translation: CAH93133.1.
RefSeq	NP_001128733.1. NM_001135261.1.
UniGene	Pab.18139.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000012805; ENSPPYP00000012323; ENSPPYG00000011035.
GeneID	100173651.
KEGG	pon:100173651.
Organism-specific databases
CTD	10955.
Phylogenomic databases
GeneTree	ENSGT00550000074522.
HOGENOM	HOG000165463.
HOVERGEN	HBG025699.
InParanoid	Q5R533.
OMA	CCPNSKN.
OrthoDB	EOG4S4PGF.
Family and domain databases
InterPro	IPR005016. TMS_TDE. [Graphical view]
PANTHER	PTHR10383. PTHR10383. 1 hit.
Pfam	PF03348. Serinc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SERC3_PONAB

Accession

Primary (citable) accession number: Q5R533

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program