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Q5R514 (UMPS_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uridine 5'-monophosphate synthase

Short name=UMP synthase

Including the following 2 domains:

  1. Orotate phosphoribosyltransferase
    Short name=OPRTase
    EC=2.4.2.10
  2. Orotidine 5'-phosphate decarboxylase
    EC=4.1.1.23
    Alternative name(s):
    OMPdecase
Gene names
Name:UMPS
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01208

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP-Rule MF_01208

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01208

Sequence similarities

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

In the C-terminal section; belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 480479Uridine 5'-monophosphate synthase HAMAP-Rule MF_01208
PRO_0000257814

Regions

Region2 – 214213OPRTase HAMAP-Rule MF_01208
Region215 – 2206Domain linker HAMAP-Rule MF_01208
Region221 – 480260OMPdecase HAMAP-Rule MF_01208

Sites

Active site3141For OMPdecase activity By similarity
Active site3171For OMPdecase activity By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue2141Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R514 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 18DBEA8FCF5DB6BC

FASTA48052,128
        10         20         30         40         50         60 
MAAVGAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADTLFQT 

        70         80         90        100        110        120 
AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET KDYGTKRLVE GTINPGETCL 

       130        140        150        160        170        180 
IIEDVVTSGS SVLETAEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML 

       190        200        210        220        230        240 
EILEQQKKID AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFSAR AELPRIHPVA 

       250        260        270        280        290        300 
SKLLRLMQKK ETNLCLSADV SEARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT 

       310        320        330        340        350        360 
LAKRHEFLIF EDRKFADIGN TVKKQYEGGV FKIASWADLV NAHVVPGSGV VKGLQEVGLP 

       370        380        390        400        410        420 
LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ 

       430        440        450        460        470        480 
LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG RGIISAADCL EAAEMYRKAA WEAYLSRLGV 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR861071 mRNA. Translation: CAH93152.1.
RefSeqNP_001126858.1. NM_001133386.1.
UniGenePab.1766.

3D structure databases

ProteinModelPortalQ5R514.
SMRQ5R514. Positions 221-479.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R514.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173867.
KEGGpon:100173867.

Organism-specific databases

CTD7372.

Phylogenomic databases

HOVERGENHBG000870.
InParanoidQ5R514.
KOK13421.

Enzyme and pathway databases

UniPathwayUPA00070; UER00119.
UPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPMF_01208. PyrE.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUMPS_PONAB
AccessionPrimary (citable) accession number: Q5R514
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways