Q5R4Y7 (PLD3_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipase D3
Short name=PLD 3
EC=3.1.4.4

Alternative name(s):
Choline phosphatase 3
Phosphatidylcholine-hydrolyzing phospholipase D3

Gene names

Name:

PLD3

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.
Post-translational modification	Glycosylated By similarity.
Sequence similarities	Belongs to the phospholipase D family. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Endoplasmic reticulum Membrane
Domain	Repeat Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Phospholipase D3		PRO_0000280329
Regions
	Topological domain	1 – 38	38	Cytoplasmic Potential
	Transmembrane	39 – 59	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	60 – 490	431	Lumenal Potential
	Domain	196 – 223	28	PLD phosphodiesterase 1
	Domain	411 – 437	27	PLD phosphodiesterase 2
Sites
	Active site	201	1	Potential
	Active site	203	1	Potential
	Active site	208	1	Potential
Amino acid modifications
	Glycosylation	132	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	65	1	L → S in CAH93251. Ref.1
	Sequence conflict	165	1	V → M in CAH93251. Ref.1
	Sequence conflict	340	1	R → G in CAH93251. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5R4Y7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 4A0D295A1A73D808	FASTA	490	54,702
	10 20 30 40 50 60 MKPKLMYQEL KVPAEEPANE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW 70 80 90 100 110 120 EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST GNPSTSQAWL GLLAGAHSSL 130 140 150 160 170 180 DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ LQTLAPKGVN VRIAVSKPNG PQPQADLQAL 190 200 210 220 230 240 LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL 250 260 270 280 290 300 ARDLTKIFEA YWFLGQAGSS IPSTWPRFYD TRYNQETPME ICLNGTPALA YLASAPPPLC 310 320 330 340 350 360 PSGRTPDLKA LLNVVDNARS FIYVAVMNYL PTLEFSHPHR FWPAIDDGLR RAAYERGVKV 370 380 390 400 410 420 RLLISCWGHS EPSMRAFLLS LAALRDNHTH SDIQVKLFVV PADEAQARIP YARVNHNKYM 430 440 450 460 470 480 VTERATYIGT SNWSGNYFTE TAGTSLLVTQ NGRGGLRSQL EAIFLRDWDS PYSHDLDTSA 490 DSVGNACRLL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR861101 mRNA. Translation: CAH93179.1. CR861179 mRNA. Translation: CAH93251.1.
RefSeq	NP_001126871.1. NM_001133399.1.
UniGene	Pab.18073.
3D structure databases
ProteinModelPortal	Q5R4Y7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000011618; ENSPPYP00000011181; ENSPPYG00000009988.
GeneID	100173883.
KEGG	pon:100173883.
Organism-specific databases
CTD	23646.
Phylogenomic databases
HOVERGEN	HBG052880.
InParanoid	Q5R4Y7.
OMA	IDIASFY.
OrthoDB	EOG4M65HG.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. IPR013582. PLipase_D_envelope. [Graphical view]
Pfam	PF08371. PLD_envelope. 1 hit. PF00614. PLDc. 1 hit. [Graphical view]
SMART	SM00155. PLDc. 2 hits. [Graphical view]
PROSITE	PS50035. PLD. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD3_PONAB

Accession

Primary (citable) accession number: Q5R4Y7
Secondary accession number(s): Q5R4R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	December 21, 2004
Last modified:	October 19, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program