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Q5R4W0

- ECHD1_PONAB

UniProt

Q5R4W0 - ECHD1_PONAB

Protein

Ethylmalonyl-CoA decarboxylase

Gene

ECHDC1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.By similarity

    Catalytic activityi

    (S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
    (S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

    GO - Molecular functioni

    1. carboxy-lyase activity Source: UniProtKB
    2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
    Alternative name(s):
    Enoyl-CoA hydratase domain-containing protein 1
    Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
    Short name:
    MMCD
    Gene namesi
    Name:ECHDC1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Ethylmalonyl-CoA decarboxylasePRO_0000273248Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei211 – 2111N6-acetyllysine; alternateBy similarity
    Modified residuei211 – 2111N6-succinyllysine; alternateBy similarity
    Modified residuei295 – 2951N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R4W0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG054783.
    InParanoidiQ5R4W0.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view]
    PfamiPF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5R4W0-1 [UniParc]FASTAAdd to Basket

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    MAKSLLKTSS LSGRTKLLHQ TGLSLYSTSH GFYEEEVKKT LQQFPGGSID    50
    LQKEDNGIGI LTLNNPSKMN AFSGVMMLQL LEKVIELENW TEGKGLIVRG 100
    AKNTFSSGSD LNAVKSLGTP EDGMAVCMFM QNTLTRFMRL PLISVALVQG 150
    WALGGGAEFT TACDFRLMTP ESKIRFVHKE MGIIPSWGGT TRLVEIIGSR 200
    QALKVLSGAL KLDSKNALNI GMVEEVLQSS DETKSLEEAQ EWLKQFIQGP 250
    PEVIRALKKS VCSGRELYLE EALQNERDLL GTVWGGPANL EAIAKKGKFN 300
    K 301
    Length:301
    Mass (Da):32,985
    Last modified:December 21, 2004 - v1
    Checksum:iEC74C79DA2FB6FD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR861131 mRNA. Translation: CAH93206.1.
    CR925967 mRNA. Translation: CAI29618.1.
    RefSeqiNP_001126886.1. NM_001133414.1.

    Genome annotation databases

    GeneIDi100173900.
    KEGGipon:100173900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR861131 mRNA. Translation: CAH93206.1 .
    CR925967 mRNA. Translation: CAI29618.1 .
    RefSeqi NP_001126886.1. NM_001133414.1.

    3D structure databases

    ProteinModelPortali Q5R4W0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100173900.
    KEGGi pon:100173900.

    Organism-specific databases

    CTDi 55862.

    Phylogenomic databases

    HOVERGENi HBG054783.
    InParanoidi Q5R4W0.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view ]
    Pfami PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiECHD1_PONAB
    AccessioniPrimary (citable) accession number: Q5R4W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3