Q5R4W0 (ECHD1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ethylmalonyl-CoA decarboxylase
EC=4.1.1.94

Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase
Short name=MMCD
EC=4.1.1.41

Gene names

Name:

ECHDC1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activityx at lower level By similarity.
Catalytic activity	(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2. (S)-methylmalonyl-CoA = propanoyl-CoA + CO2.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	carboxy-lyase activity Inferred from sequence or structural similarity. Source: UniProtKB methylmalonyl-CoA decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Ethylmalonyl-CoA decarboxylase		PRO_0000273248

Sequences

	Sequence		Length	Mass (Da)
	Q5R4W0 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: EC74C79DA2FB6FD8	FASTA	301	32,985
	10 20 30 40 50 60 MAKSLLKTSS LSGRTKLLHQ TGLSLYSTSH GFYEEEVKKT LQQFPGGSID LQKEDNGIGI 70 80 90 100 110 120 LTLNNPSKMN AFSGVMMLQL LEKVIELENW TEGKGLIVRG AKNTFSSGSD LNAVKSLGTP 130 140 150 160 170 180 EDGMAVCMFM QNTLTRFMRL PLISVALVQG WALGGGAEFT TACDFRLMTP ESKIRFVHKE 190 200 210 220 230 240 MGIIPSWGGT TRLVEIIGSR QALKVLSGAL KLDSKNALNI GMVEEVLQSS DETKSLEEAQ 250 260 270 280 290 300 EWLKQFIQGP PEVIRALKKS VCSGRELYLE EALQNERDLL GTVWGGPANL EAIAKKGKFN K

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR861131 mRNA. Translation: CAH93206.1. CR925967 mRNA. Translation: CAI29618.1.
RefSeq	NP_001126886.1. NM_001133414.1.
UniGene	Pab.17865.
3D structure databases
ProteinModelPortal	Q5R4W0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100173900.
KEGG	pon:100173900.
Organism-specific databases
CTD	55862.
Phylogenomic databases
HOVERGEN	HBG054783.
InParanoid	Q5R4W0.
Family and domain databases
InterPro	IPR001753. Crotonase_core_superfam. IPR018376. Enoyl-CoA_hyd/isom_CS. [Graphical view]
Pfam	PF00378. ECH. 1 hit. [Graphical view]
PROSITE	PS00166. ENOYL_COA_HYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECHD1_PONAB

Accession

Primary (citable) accession number: Q5R4W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program