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Protein

Ethylmalonyl-CoA decarboxylase

Gene

ECHDC1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).By similarity

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:ECHDC1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Ethylmalonyl-CoA decarboxylasePRO_0000273248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111N6-acetyllysine; alternateBy similarity
Modified residuei211 – 2111N6-succinyllysine; alternateBy similarity
Modified residuei295 – 2951N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000024266.

Structurei

3D structure databases

ProteinModelPortaliQ5R4W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG054783.
InParanoidiQ5R4W0.
KOiK18426.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R4W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSLLKTSS LSGRTKLLHQ TGLSLYSTSH GFYEEEVKKT LQQFPGGSID
60 70 80 90 100
LQKEDNGIGI LTLNNPSKMN AFSGVMMLQL LEKVIELENW TEGKGLIVRG
110 120 130 140 150
AKNTFSSGSD LNAVKSLGTP EDGMAVCMFM QNTLTRFMRL PLISVALVQG
160 170 180 190 200
WALGGGAEFT TACDFRLMTP ESKIRFVHKE MGIIPSWGGT TRLVEIIGSR
210 220 230 240 250
QALKVLSGAL KLDSKNALNI GMVEEVLQSS DETKSLEEAQ EWLKQFIQGP
260 270 280 290 300
PEVIRALKKS VCSGRELYLE EALQNERDLL GTVWGGPANL EAIAKKGKFN

K
Length:301
Mass (Da):32,985
Last modified:December 21, 2004 - v1
Checksum:iEC74C79DA2FB6FD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861131 mRNA. Translation: CAH93206.1.
CR925967 mRNA. Translation: CAI29618.1.
RefSeqiNP_001126886.1. NM_001133414.1.
XP_009240496.1. XM_009242221.1.

Genome annotation databases

GeneIDi100173900.
KEGGipon:100173900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861131 mRNA. Translation: CAH93206.1.
CR925967 mRNA. Translation: CAI29618.1.
RefSeqiNP_001126886.1. NM_001133414.1.
XP_009240496.1. XM_009242221.1.

3D structure databases

ProteinModelPortaliQ5R4W0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000024266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173900.
KEGGipon:100173900.

Organism-specific databases

CTDi55862.

Phylogenomic databases

HOVERGENiHBG054783.
InParanoidiQ5R4W0.
KOiK18426.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiECHD1_PONAB
AccessioniPrimary (citable) accession number: Q5R4W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.