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Q5R4W0

- ECHD1_PONAB

UniProt

Q5R4W0 - ECHD1_PONAB

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Protein

Ethylmalonyl-CoA decarboxylase

Gene

ECHDC1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).By similarity

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:ECHDC1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Ethylmalonyl-CoA decarboxylasePRO_0000273248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111N6-acetyllysine; alternateBy similarity
Modified residuei211 – 2111N6-succinyllysine; alternateBy similarity
Modified residuei295 – 2951N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliQ5R4W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG054783.
InParanoidiQ5R4W0.
KOiK18426.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R4W0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKSLLKTSS LSGRTKLLHQ TGLSLYSTSH GFYEEEVKKT LQQFPGGSID
60 70 80 90 100
LQKEDNGIGI LTLNNPSKMN AFSGVMMLQL LEKVIELENW TEGKGLIVRG
110 120 130 140 150
AKNTFSSGSD LNAVKSLGTP EDGMAVCMFM QNTLTRFMRL PLISVALVQG
160 170 180 190 200
WALGGGAEFT TACDFRLMTP ESKIRFVHKE MGIIPSWGGT TRLVEIIGSR
210 220 230 240 250
QALKVLSGAL KLDSKNALNI GMVEEVLQSS DETKSLEEAQ EWLKQFIQGP
260 270 280 290 300
PEVIRALKKS VCSGRELYLE EALQNERDLL GTVWGGPANL EAIAKKGKFN

K
Length:301
Mass (Da):32,985
Last modified:December 21, 2004 - v1
Checksum:iEC74C79DA2FB6FD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR861131 mRNA. Translation: CAH93206.1.
CR925967 mRNA. Translation: CAI29618.1.
RefSeqiNP_001126886.1. NM_001133414.1.

Genome annotation databases

GeneIDi100173900.
KEGGipon:100173900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR861131 mRNA. Translation: CAH93206.1 .
CR925967 mRNA. Translation: CAI29618.1 .
RefSeqi NP_001126886.1. NM_001133414.1.

3D structure databases

ProteinModelPortali Q5R4W0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100173900.
KEGGi pon:100173900.

Organism-specific databases

CTDi 55862.

Phylogenomic databases

HOVERGENi HBG054783.
InParanoidi Q5R4W0.
KOi K18426.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view ]
Pfami PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiECHD1_PONAB
AccessioniPrimary (citable) accession number: Q5R4W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3