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Q5R4W0 (ECHD1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ethylmalonyl-CoA decarboxylase

EC=4.1.1.94
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase
Short name=MMCD
EC=4.1.1.41
Gene names
Name:ECHDC1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.

Catalytic activity

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.

(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionLyase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncarboxy-lyase activity

Inferred from sequence or structural similarity. Source: UniProtKB

methylmalonyl-CoA decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Ethylmalonyl-CoA decarboxylase
PRO_0000273248

Amino acid modifications

Modified residue2111N6-acetyllysine; alternate By similarity
Modified residue2111N6-succinyllysine; alternate By similarity
Modified residue2951N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R4W0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: EC74C79DA2FB6FD8

FASTA30132,985
        10         20         30         40         50         60 
MAKSLLKTSS LSGRTKLLHQ TGLSLYSTSH GFYEEEVKKT LQQFPGGSID LQKEDNGIGI 

        70         80         90        100        110        120 
LTLNNPSKMN AFSGVMMLQL LEKVIELENW TEGKGLIVRG AKNTFSSGSD LNAVKSLGTP 

       130        140        150        160        170        180 
EDGMAVCMFM QNTLTRFMRL PLISVALVQG WALGGGAEFT TACDFRLMTP ESKIRFVHKE 

       190        200        210        220        230        240 
MGIIPSWGGT TRLVEIIGSR QALKVLSGAL KLDSKNALNI GMVEEVLQSS DETKSLEEAQ 

       250        260        270        280        290        300 
EWLKQFIQGP PEVIRALKKS VCSGRELYLE EALQNERDLL GTVWGGPANL EAIAKKGKFN 


K 

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR861131 mRNA. Translation: CAH93206.1.
CR925967 mRNA. Translation: CAI29618.1.
RefSeqNP_001126886.1. NM_001133414.1.

3D structure databases

ProteinModelPortalQ5R4W0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173900.
KEGGpon:100173900.

Organism-specific databases

CTD55862.

Phylogenomic databases

HOVERGENHBG054783.
InParanoidQ5R4W0.

Family and domain databases

Gene3D3.90.226.10. 1 hit.
InterProIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMSSF52096. SSF52096. 1 hit.
PROSITEPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameECHD1_PONAB
AccessionPrimary (citable) accession number: Q5R4W0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families