Reviewed, UniProtKB/Swiss-Prot Q5R4S7 (QOR_PONAB)

Names and origin

Protein names

Recommended name:
    Quinone oxidoreductase
    EC=1.6.5.5
Alternative name(s):
    NADPH:quinone reductase
    Zeta-crystallin

Gene names

Name:

CRYZ

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics By similarity.
Catalytic activity	NADPH + 2 quinone = NADP(+) + 2 semiquinone.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADPH:quinone reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Quinone oxidoreductase		PRO_0000160909

Sequences

	Sequence		Length	Mass (Da)
	Q5R4S7-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 6C0E97E7F832F7D9	FASTA	329	35,083
	10 20 30 40 50 60 MATGQKLMRA VRVFEFGGPE VLKLQSDIAV PIPKDHQALI KVHACGVNPV ETYIRSGTYS 70 80 90 100 110 120 RKPLLPYTPG SDVAGVIEAV GGNASAFKKG DRVFTSSTIS GGYAEYALAA DHTVYKLPEK 130 140 150 160 170 180 LDFKQGAAIG IPYFTAYRAL IHSAHVKAGE SVLVHGASGG VGLAACQIAR AYGLKVLGTA 190 200 210 220 230 240 GTEEGQKIVL QNGAHEVFNH REVNYIDKIK KYVGEKGIDV IIEMLANVNL NKDLSLLSHG 250 260 270 280 290 300 GQVIVVGSRG TIEINPRDTM AKESSIIGVT VFSSTKEEFQ QYAAALQAGM EIGWLKPVIG 310 320 SQYPLEKVAE AHENIIHGSG ATGKMILLL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR861167 mRNA. Translation: CAH93239.1.
RefSeq	NP_001126904.1.
3D structure databases
SMR	Q5R4S7. Positions 6-329.
ModBase	Search...
Genome annotation databases
GeneID	100173920.
Phylogenomic databases
HOVERGEN	Q5R4S7.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR016040. NAD(P)-bd. IPR002364. Quin_OxRdtase/zeta-crystal_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QOR_PONAB

Accession

Primary (citable) accession number: Q5R4S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)