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Q5R4S2 (B3GN1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

EC=2.4.1.149
Alternative name(s):
I-beta-1,3-N-acetylglucosaminyltransferase
Short name=iGnT
Poly-N-acetyllactosamine extension enzyme
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Gene names
Name:B3GNT1
Synonyms:B3GNT6
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. Involved in alpha-dystroglycan (DAG1) glycosylation By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 49 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
PRO_0000080557

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 3628Helical; Signal-anchor for type II membrane protein; Potential
Topological domain37 – 415379Lumenal Potential

Amino acid modifications

Glycosylation2041N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5R4S2 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: E73C1299D8F34CE2

FASTA41547,149
        10         20         30         40         50         60 
MQMSYAIRCA FYQLLLAALM LVAMLQLLYL SLLSGLHGQE EQDQYFEFFP PSPRSVDQVK 

        70         80         90        100        110        120 
TQLRTALASG GVLDASGDYR VYRGLLKTTM DPNDVILATH ASVDNLLHLS GLLERWEGPL 

       130        140        150        160        170        180 
SVSVFAATKE EAQLATVLAY ALSSHCPDMR ARVAMHLVCP SRYEAAVPDP REPGEFALLR 

       190        200        210        220        230        240 
SCQEVFDKLA RVAQPGINYA LGTNVSYPNN LLRNLAREGA NYALVIDVDM VPSEGLWRGL 

       250        260        270        280        290        300 
REMLDQSNQW GGTALVVPAF EIRRARRMPM NKNELVQLYQ VGEVRPFYYG LCTPCQAPTN 

       310        320        330        340        350        360 
YSRWVNLPEE SLLRPAYVVP WQDPWEPFYV AGGKVPTFDE RFRQYGFNRI SQACELHVAG 

       370        380        390        400        410 
FDFEVLNEGF LVHKGFKEAL KFHPQKEAEN QHNKILYRQF KQELKAKYPN SPRRC 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR861172 mRNA. Translation: CAH93244.1.
RefSeqNP_001126908.1. NM_001133436.1.
UniGenePab.17541.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT49. Glycosyltransferase Family 49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173924.
KEGGpon:100173924.

Organism-specific databases

CTD10678.

Phylogenomic databases

HOVERGENHBG080885.
InParanoidQ5R4S2.
KOK00741.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR026603. N-AclacN_B-1_3-N-AclacNTrfase.
[Graphical view]
PANTHERPTHR12270:SF3. PTHR12270:SF3. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB3GN1_PONAB
AccessionPrimary (citable) accession number: Q5R4S2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways