Reviewed, UniProtKB/Swiss-Prot Q5R4G0 (SGPL1_PONAB)

Names and origin

Protein names

Recommended name:
    Sphingosine-1-phosphate lyase 1
      Short name=SP-lyase 1
      Short name=SPL 1
      Short name=SPL
    EC=4.1.2.27
Alternative name(s):
    Sphingosine-1-phosphate aldolase

Gene names

Name:

SGPL1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis By similarity.
Catalytic activity	Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Lipid metabolism; sphingolipid metabolism.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity.
Sequence similarities	Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.

Ontologies

Keywords
Biological process	Apoptosis Lipid metabolism
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal-anchor Transmembrane
Ligand	Pyridoxal phosphate
Molecular function	Lyase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW carboxylic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carboxy-lyase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro sphinganine-1-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Sphingosine-1-phosphate lyase 1		PRO_0000248943
Regions
	Topological domain	1 – 41	41	Lumenal Potential
	Transmembrane	42 – 62	21	Signal-anchor for type III membrane protein Potential
	Topological domain	63 – 568	506	Cytoplasmic Potential
Amino acid modifications
	Modified residue	353	1	N6-(pyridoxal phosphate)lysine By similarity
	Modified residue	353	1	N6-acetyllysine By similarity
	Modified residue	468	1	Phosphothreonine By similarity
	Modified residue	564	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R4G0-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 0DFA7E82D95C1DA3	FASTA	568	63,472
	10 20 30 40 50 60 MPSTDLLTLK AFEPYLEILE VYSTKAKNYV NGHCTKYEPW QLIAWSVVWT LLIVWGYEFV 70 80 90 100 110 120 FQPESLWSRF KKKCFKLTRK MPIIGRKIQD KLNKTKDDIS KNMSFLKVDK EYVKALPSQG 130 140 150 160 170 180 LSSSAVLEKL KEYSSMDAFW QEGRASGTVY SGEEKLTELL VKAYGDFAWS NPLHPDIFPG 190 200 210 220 230 240 LRKIEAEIVR IACSLFNGGP DSCGCVTSGG TESILMACKA YRDLAFEKGI KTSEIVAPQS 250 260 270 280 290 300 AHAAFNKAAS YFGMKIVRVP LTKMMEVDVR AMRRAISRNT AMLVCSTPQF PHGVIDPVPE 310 320 330 340 350 360 VAKLAVKYKI PLHVDACLGG FLTVFMEKAG YPLEHPFDFR VKGVTSISAD THKYGYAPKG 370 380 390 400 410 420 SSLVLYSDKK YRNYQFFVDT DWQGGIYASP TIAGSRPGGI SAACWAALMH FGENGYVEAT 430 440 450 460 470 480 KQIIKTARFL KSELENIKGI FVFGNPQLSV IALGSRDFDI YRLSNLMTAK GWNLNQLQFP 490 500 510 520 530 540 PSIHFCITLL HARKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ TTVDRNMVAE 550 560 LSSVFLDSLY STDTVTQGSQ MNGSPKPH

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR861289 mRNA. Translation: CAH93356.1.
RefSeq	NP_001126976.1.
UniGene	Pab.1677
3D structure databases
SMR	Q5R4G0. Positions 115-515.
ModBase	Search...
Genome annotation databases
GeneID	100173995.
Organism-specific databases
CTD	100173995.
Phylogenomic databases
HOVERGEN	Q5R4G0.
InParanoid	Q5R4G0.
Enzyme and pathway databases
BRENDA	4.1.2.27. 269192.
Family and domain databases
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11999. Pyridoxal_deC. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
PROSITE	PS00392. DDC_GAD_HDC_YDC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SGPL1_PONAB

Accession

Primary (citable) accession number: Q5R4G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	December 21, 2004
Last modified:	January 19, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)