Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5R4C4 (UBCP1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-like domain-containing CTD phosphatase 1

EC=3.1.3.16
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene names
Name:UBLCP1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Magnesium By similarity.

Subcellular location

Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.

Domain

The Ubiquitin-like domain mediates interaction with proteasomes By similarity.

Sequence similarities

Contains 1 FCP1 homology domain.

Contains 1 ubiquitin-like domain.

Ontologies

Keywords
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 318317Ubiquitin-like domain-containing CTD phosphatase 1
PRO_0000242642

Regions

Domain3 – 8179Ubiquitin-like
Domain133 – 294162FCP1 homology
Region133 – 294162Phosphatase By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1171N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R4C4 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 23A6DDB17A0E6E0F

FASTA31836,675
        10         20         30         40         50         60 
MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV KGKPAENDVK 

        70         80         90        100        110        120 
LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVVNDFD IEDEVVEVEN REENLLKISR 

       130        140        150        160        170        180 
RVKEYKVEIL NPPREGKKLL VLDVDYTLFD HRSCAETGVE LMRPYLHEFL TSAYEDYDIV 

       190        200        210        220        230        240 
IWSATNMKWI EAKMKELGVS TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS 

       250        260        270        280        290        300 
EFYSKKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKGLLKLTQY LKEIAKLDDF 

       310 
LGLNHKYWER YLSKKQGQ 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR861328 mRNA. Translation: CAH93392.1.
RefSeqNP_001126990.1. NM_001133518.1.
UniGenePab.2189.

3D structure databases

ProteinModelPortalQ5R4C4.
SMRQ5R4C4. Positions 2-79.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R4C4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174013.
KEGGpon:100174013.

Organism-specific databases

CTD134510.

Phylogenomic databases

HOVERGENHBG080207.
InParanoidQ5R4C4.
KOK17618.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
[Graphical view]
PfamPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02245. HAD_IIID1. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBCP1_PONAB
AccessionPrimary (citable) accession number: Q5R4C4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families