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Protein

Sorting nexin-4

Gene

SNX4

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Phosphatidylinositol 3-phosphateBy similarity
Binding sitei108 – 1081Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei132 – 1321Phosphatidylinositol 3-phosphateBy similarity
Binding sitei154 – 1541Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:SNX4
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Sorting nexin-4PRO_0000213843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015056.

Structurei

3D structure databases

ProteinModelPortaliQ5R4C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 187127PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00840000129805.
HOVERGENiHBG017826.
InParanoidiQ5R4C2.
KOiK17919.
OMAiKSAWADI.
OrthoDBiEOG091G0CLA.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R4C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQAPPDPER QLQPAPLEPL GSPDAVLGAA VGKETEGAGE ESSGVDTMTH
60 70 80 90 100
NNFWLKKIEI SVSEAEKRTG RNAMNMQETY TAYLIETRSI EHTDGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRSYLLVY YPHIVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRIGLEN FLLRIASHPL LCRDKIFYLF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELATGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV
410 420 430 440 450
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):51,967
Last modified:December 21, 2004 - v1
Checksum:iB2259BD469A292F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861330 mRNA. Translation: CAH93394.1.
RefSeqiNP_001126992.1. NM_001133520.1.

Genome annotation databases

EnsembliENSPPYT00000015658; ENSPPYP00000015056; ENSPPYG00000013461.
GeneIDi100174015.
KEGGipon:100174015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861330 mRNA. Translation: CAH93394.1.
RefSeqiNP_001126992.1. NM_001133520.1.

3D structure databases

ProteinModelPortaliQ5R4C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000015658; ENSPPYP00000015056; ENSPPYG00000013461.
GeneIDi100174015.
KEGGipon:100174015.

Organism-specific databases

CTDi8723.

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00840000129805.
HOVERGENiHBG017826.
InParanoidiQ5R4C2.
KOiK17919.
OMAiKSAWADI.
OrthoDBiEOG091G0CLA.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX4_PONAB
AccessioniPrimary (citable) accession number: Q5R4C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.