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Protein

AP-3 complex subunit mu-1

Gene

AP3M1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit mu-1
Alternative name(s):
AP-3 adaptor complex mu3A subunit
Adaptor-related protein complex 3 subunit mu-1
Mu-adaptin 3A
Mu3A-adaptin
Gene namesi
Name:AP3M1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002858051 – 418AP-3 complex subunit mu-1Add BLAST418

Proteomic databases

PRIDEiQ5R478.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000002697.

Structurei

3D structure databases

ProteinModelPortaliQ5R478.
SMRiQ5R478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 417MHDPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2740. Eukaryota.
ENOG410XT7B. LUCA.
GeneTreeiENSGT00530000062779.
HOVERGENiHBG104910.
InParanoidiQ5R478.
KOiK12398.
OMAiEMIRPPT.
OrthoDBiEOG091G088V.
TreeFamiTF315187.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5R478-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS
60 70 80 90 100
TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA
110 120 130 140 150
AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS
160 170 180 190 200
SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA
210 220 230 240 250
EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF
260 270 280 290 300
IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN
310 320 330 340 350
MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLT WDVGKITPQK
360 370 380 390 400
LPSLKGLVNL QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK
410
PFKGVKYVTK AGKFQVRT
Length:418
Mass (Da):46,939
Last modified:December 21, 2004 - v1
Checksum:i533E189C320C4C48
GO
Isoform 2 (identifier: Q5R478-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     339-361: LTWDVGKITPQKLPSLKGLVNLQ → QPLQIKSTNMGCGKNYSTKAPKS
     362-418: Missing.

Show »
Length:361
Mass (Da):40,447
Checksum:iA63EA9439568EC71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108I → T in CAH90960 (Ref. 1) Curated1
Sequence conflicti261S → P in CAH90960 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024916339 – 361LTWDV…LVNLQ → QPLQIKSTNMGCGKNYSTKA PKS in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_024917362 – 418Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858751 mRNA. Translation: CAH90960.1.
CR861379 mRNA. Translation: CAH93438.1.
RefSeqiNP_001125552.1. NM_001132080.1.
NP_001127013.1. NM_001133541.1. [Q5R478-1]
XP_009243726.1. XM_009245451.1. [Q5R478-1]
XP_009243727.1. XM_009245452.1. [Q5R478-1]
UniGeneiPab.17819.

Genome annotation databases

EnsembliENSPPYT00000002788; ENSPPYP00000002697; ENSPPYG00000002322. [Q5R478-1]
GeneIDi100172465.
100174037.
KEGGipon:100172465.
pon:100174037.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858751 mRNA. Translation: CAH90960.1.
CR861379 mRNA. Translation: CAH93438.1.
RefSeqiNP_001125552.1. NM_001132080.1.
NP_001127013.1. NM_001133541.1. [Q5R478-1]
XP_009243726.1. XM_009245451.1. [Q5R478-1]
XP_009243727.1. XM_009245452.1. [Q5R478-1]
UniGeneiPab.17819.

3D structure databases

ProteinModelPortaliQ5R478.
SMRiQ5R478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000002697.

Proteomic databases

PRIDEiQ5R478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000002788; ENSPPYP00000002697; ENSPPYG00000002322. [Q5R478-1]
GeneIDi100172465.
100174037.
KEGGipon:100172465.
pon:100174037.

Organism-specific databases

CTDi26985.

Phylogenomic databases

eggNOGiKOG2740. Eukaryota.
ENOG410XT7B. LUCA.
GeneTreeiENSGT00530000062779.
HOVERGENiHBG104910.
InParanoidiQ5R478.
KOiK12398.
OMAiEMIRPPT.
OrthoDBiEOG091G088V.
TreeFamiTF315187.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP3M1_PONAB
AccessioniPrimary (citable) accession number: Q5R478
Secondary accession number(s): Q5RBA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.