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Protein

Magnesium transporter MRS2 homolog, mitochondrial

Gene

MRS2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter MRS2 homolog, mitochondrial
Alternative name(s):
MRS2-like protein
Gene namesi
Name:MRS2
Synonyms:MRS2L
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 339Mitochondrial matrixSequence analysisAdd BLAST290
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 372Mitochondrial intermembraneSequence analysisAdd BLAST12
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 443Mitochondrial matrixSequence analysisAdd BLAST50

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
ChainiPRO_000004284050 – 443Magnesium transporter MRS2 homolog, mitochondrialAdd BLAST394

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000018202.

Structurei

3D structure databases

ProteinModelPortaliQ5R447.
SMRiQ5R447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2662. Eukaryota.
ENOG410XNNZ. LUCA.
HOVERGENiHBG103267.
InParanoidiQ5R447.
KOiK16075.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECLRSLPCL LPRAMRLPRR TLCALALDLT SVAPPVAASG RRANLIGRSR
60 70 80 90 100
AAQLCEPGRL RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF
110 120 130 140 150
ERKKTELYQE LGLQARDLRF QHVMSITVRN NRIIMRMEYL KAVITPECLL
160 170 180 190 200
ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY PLPFEFRAIE ALLQYWINTL
210 220 230 240 250
QGKLSVLQPL ILETLDALVD PKHSSVDKSK LHILLQNGKS LSELETDIKI
260 270 280 290 300
FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY
310 320 330 340 350
RLADDLSNAA RELRVLIDDS QSIIFINLGS HRNVMMRLNL QLTMGTFSLS
360 370 380 390 400
LFGLMGVAFG MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL
410 420 430 440
EAPLPPMMAS LPKKTLLADR SMELKNSLRL DGLGSGRSIL TNR
Length:443
Mass (Da):50,244
Last modified:December 21, 2004 - v1
Checksum:i1DC2C7DA71AC1820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861413 mRNA. Translation: CAH93469.1.
RefSeqiNP_001127033.1. NM_001133561.1.

Genome annotation databases

GeneIDi100174059.
KEGGipon:100174059.

Similar proteinsi

Entry informationi

Entry nameiMRS2_PONAB
AccessioniPrimary (citable) accession number: Q5R447
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: September 27, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families