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Q5R3Z7

- NELL2_PONAB

UniProt

Q5R3Z7 - NELL2_PONAB

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Protein
Protein kinase C-binding protein NELL2
Gene
NELL2
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:NELL2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 816795Protein kinase C-binding protein NELL2
PRO_0000354682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi401 ↔ 413 By similarity
Disulfide bondi407 ↔ 422 By similarity
Disulfide bondi424 ↔ 438 By similarity
Disulfide bondi444 ↔ 457 By similarity
Disulfide bondi451 ↔ 466 By similarity
Disulfide bondi468 ↔ 480 By similarity
Disulfide bondi486 ↔ 499 By similarity
Disulfide bondi493 ↔ 508 By similarity
Disulfide bondi510 ↔ 521 By similarity
Glycosylationi517 – 5171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi525 ↔ 535 By similarity
Disulfide bondi529 ↔ 541 By similarity
Disulfide bondi543 ↔ 552 By similarity
Disulfide bondi559 ↔ 572 By similarity
Disulfide bondi566 ↔ 581 By similarity
Disulfide bondi583 ↔ 600 By similarity
Disulfide bondi606 ↔ 619 By similarity
Disulfide bondi613 ↔ 628 By similarity
Glycosylationi615 – 6151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi630 ↔ 636 By similarity
Glycosylationi635 – 6351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R3Z7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 228165Laminin G-like
Add
BLAST
Domaini272 – 33160VWFC 1
Add
BLAST
Domaini397 – 43943EGF-like 1
Add
BLAST
Domaini440 – 48142EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini482 – 52241EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini523 – 55331EGF-like 4
Add
BLAST
Domaini555 – 60147EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini602 – 63736EGF-like 6; calcium-binding Reviewed prediction
Add
BLAST
Domaini638 – 69356VWFC 2
Add
BLAST
Domaini698 – 75659VWFC 3
Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004805.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5R3Z7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG    50
LHNGTKAFLF QDTPRSVKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS 100
GVILSIHHLD HRYLELESSG HRNEVRLHYR SGSHRPHTEV FPYILADDKW 150
HKLSLAISAS HLILHIDCNK IYERVVEKPS TDLPLGTTFW LGQRNNAHGY 200
FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 250
TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT 300
IQCETLICPN PDCPLNSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY 350
SSSGVCVLYE CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF 400
CSERHNCMEN SVCRNLNDRA VCSCRDGFRA LREDNAYCED IDECAEGRHY 450
CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECITNQ HNCDENALCF 500
NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV CACPQGFTGP 550
SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 600
EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG 650
QIWVLENDRC SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC 700
LHQNGETLYN SGDTWVQNCQ QCRCLQGEVD CWPLPCPDVE CEFSILPENE 750
CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH GTECTLCQCK 800
NGHICCSVDP QCLQEL 816
Length:816
Mass (Da):91,304
Last modified:November 25, 2008 - v2
Checksum:iFD61E3C23C99750A
GO
Isoform 2 (identifier: Q5R3Z7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-18: SRVLLRTFCLIFGLGA → TGLGAPLFKAWLLIS

Note: No experimental confirmation available.

Show »
Length:815
Mass (Da):91,125
Checksum:iE42BE29AFC1553FF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3 – 1816SRVLL…FGLGA → TGLGAPLFKAWLLIS in isoform 2.
VSP_035803Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371H → R in CAH91436. 1 Publication
Sequence conflicti456 – 4561M → T in CAH91436. 1 Publication
Sequence conflicti496 – 4961N → S in CAH91436. 1 Publication
Sequence conflicti531 – 5311N → S in CAH93519. 1 Publication
Sequence conflicti545 – 5451Q → H in CAH90631. 1 Publication
Sequence conflicti616 – 6161D → G in CAH90631. 1 Publication
Sequence conflicti683 – 6831T → I in CAH90631. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858404 mRNA. Translation: CAH90631.1.
CR859256 mRNA. Translation: CAH91436.1.
CR861463 mRNA. Translation: CAH93519.1.
RefSeqiNP_001125844.1. NM_001132372.1.
NP_001128913.1. NM_001135441.1.
UniGeneiPab.19040.

Genome annotation databases

GeneIDi100172773.
100189859.
KEGGipon:100172773.
pon:100189859.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858404 mRNA. Translation: CAH90631.1 .
CR859256 mRNA. Translation: CAH91436.1 .
CR861463 mRNA. Translation: CAH93519.1 .
RefSeqi NP_001125844.1. NM_001132372.1.
NP_001128913.1. NM_001135441.1.
UniGenei Pab.19040.

3D structure databases

ProteinModelPortali Q5R3Z7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100172773.
100189859.
KEGGi pon:100172773.
pon:100189859.

Organism-specific databases

CTDi 4753.

Phylogenomic databases

HOVERGENi HBG004805.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex.

Entry informationi

Entry nameiNELL2_PONAB
AccessioniPrimary (citable) accession number: Q5R3Z7
Secondary accession number(s): Q5R9X4, Q5RC76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: February 19, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi