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Q5R3Z7 (NELL2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene names
Name:NELL2
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length816 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homotrimer. Binds to PKC beta-1 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 6 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 3 VWFC domains.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5R3Z7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5R3Z7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3-18: SRVLLRTFCLIFGLGA → TGLGAPLFKAWLLIS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 816795Protein kinase C-binding protein NELL2
PRO_0000354682

Regions

Domain64 – 228165Laminin G-like
Domain272 – 33160VWFC 1
Domain397 – 43943EGF-like 1
Domain440 – 48142EGF-like 2; calcium-binding Potential
Domain482 – 52241EGF-like 3; calcium-binding Potential
Domain523 – 55331EGF-like 4
Domain555 – 60147EGF-like 5; calcium-binding Potential
Domain602 – 63736EGF-like 6; calcium-binding Potential
Domain638 – 69356VWFC 2
Domain698 – 75659VWFC 3

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation5171N-linked (GlcNAc...) Potential
Glycosylation6151N-linked (GlcNAc...) Potential
Glycosylation6351N-linked (GlcNAc...) Potential
Disulfide bond401 ↔ 413 By similarity
Disulfide bond407 ↔ 422 By similarity
Disulfide bond424 ↔ 438 By similarity
Disulfide bond444 ↔ 457 By similarity
Disulfide bond451 ↔ 466 By similarity
Disulfide bond468 ↔ 480 By similarity
Disulfide bond486 ↔ 499 By similarity
Disulfide bond493 ↔ 508 By similarity
Disulfide bond510 ↔ 521 By similarity
Disulfide bond525 ↔ 535 By similarity
Disulfide bond529 ↔ 541 By similarity
Disulfide bond543 ↔ 552 By similarity
Disulfide bond559 ↔ 572 By similarity
Disulfide bond566 ↔ 581 By similarity
Disulfide bond583 ↔ 600 By similarity
Disulfide bond606 ↔ 619 By similarity
Disulfide bond613 ↔ 628 By similarity
Disulfide bond630 ↔ 636 By similarity

Natural variations

Alternative sequence3 – 1816SRVLL…FGLGA → TGLGAPLFKAWLLIS in isoform 2.
VSP_035803

Experimental info

Sequence conflict1371H → R in CAH91436. Ref.1
Sequence conflict4561M → T in CAH91436. Ref.1
Sequence conflict4961N → S in CAH91436. Ref.1
Sequence conflict5311N → S in CAH93519. Ref.1
Sequence conflict5451Q → H in CAH90631. Ref.1
Sequence conflict6161D → G in CAH90631. Ref.1
Sequence conflict6831T → I in CAH90631. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: FD61E3C23C99750A

FASTA81691,304
        10         20         30         40         50         60 
MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF 

        70         80         90        100        110        120 
QDTPRSVKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG 

       130        140        150        160        170        180 
HRNEVRLHYR SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS 

       190        200        210        220        230        240 
TDLPLGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK 

       250        260        270        280        290        300 
IMELQDILAK TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT 

       310        320        330        340        350        360 
IQCETLICPN PDCPLNSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE 

       370        380        390        400        410        420 
CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SVCRNLNDRA 

       430        440        450        460        470        480 
VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC 

       490        500        510        520        530        540 
TEHDECITNQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV 

       550        560        570        580        590        600 
CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 

       610        620        630        640        650        660 
EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC 

       670        680        690        700        710        720 
SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ 

       730        740        750        760        770        780 
QCRCLQGEVD CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV 

       790        800        810 
RFTGSSWIKH GTECTLCQCK NGHICCSVDP QCLQEL

« Hide

Isoform 2 [UniParc].

Checksum: E42BE29AFC1553FF
Show »

FASTA81591,125

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR858404 mRNA. Translation: CAH90631.1.
CR859256 mRNA. Translation: CAH91436.1.
CR861463 mRNA. Translation: CAH93519.1.
RefSeqNP_001125844.1. NM_001132372.1.
NP_001128913.1. NM_001135441.1.
UniGenePab.19040.
Pab.19641.

3D structure databases

HSSPHSSP built from PDB template 1Z6C based on UniProtKB P07225.
ProteinModelPortalQ5R3Z7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100172773.
100189859.
KEGGpon:100172773.
pon:100189859.

Organism-specific databases

CTD4753.

Phylogenomic databases

HOVERGENHBG004805.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 2 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. False negative.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNELL2_PONAB
AccessionPrimary (citable) accession number: Q5R3Z7
Secondary accession number(s): Q5R9X4, Q5RC76
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: March 6, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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