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Q5R3Z7

- NELL2_PONAB

UniProt

Q5R3Z7 - NELL2_PONAB

Protein

Protein kinase C-binding protein NELL2

Gene

NELL2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL2
    Alternative name(s):
    NEL-like protein 2
    Gene namesi
    Name:NELL2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 816795Protein kinase C-binding protein NELL2PRO_0000354682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi401 ↔ 413PROSITE-ProRule annotation
    Disulfide bondi407 ↔ 422PROSITE-ProRule annotation
    Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
    Disulfide bondi444 ↔ 457PROSITE-ProRule annotation
    Disulfide bondi451 ↔ 466PROSITE-ProRule annotation
    Disulfide bondi468 ↔ 480PROSITE-ProRule annotation
    Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
    Disulfide bondi493 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi510 ↔ 521PROSITE-ProRule annotation
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
    Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
    Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
    Disulfide bondi559 ↔ 572PROSITE-ProRule annotation
    Disulfide bondi566 ↔ 581PROSITE-ProRule annotation
    Disulfide bondi583 ↔ 600PROSITE-ProRule annotation
    Disulfide bondi606 ↔ 619PROSITE-ProRule annotation
    Disulfide bondi613 ↔ 628PROSITE-ProRule annotation
    Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi630 ↔ 636PROSITE-ProRule annotation
    Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homotrimer. Binds to PKC beta-1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R3Z7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 228165Laminin G-likeAdd
    BLAST
    Domaini272 – 33160VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 43943EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini440 – 48142EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 52241EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini523 – 55331EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini555 – 60147EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 63736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini638 – 69356VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini698 – 75659VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG004805.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5R3Z7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG    50
    LHNGTKAFLF QDTPRSVKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS 100
    GVILSIHHLD HRYLELESSG HRNEVRLHYR SGSHRPHTEV FPYILADDKW 150
    HKLSLAISAS HLILHIDCNK IYERVVEKPS TDLPLGTTFW LGQRNNAHGY 200
    FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 250
    TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT 300
    IQCETLICPN PDCPLNSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY 350
    SSSGVCVLYE CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF 400
    CSERHNCMEN SVCRNLNDRA VCSCRDGFRA LREDNAYCED IDECAEGRHY 450
    CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECITNQ HNCDENALCF 500
    NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV CACPQGFTGP 550
    SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 600
    EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG 650
    QIWVLENDRC SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC 700
    LHQNGETLYN SGDTWVQNCQ QCRCLQGEVD CWPLPCPDVE CEFSILPENE 750
    CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH GTECTLCQCK 800
    NGHICCSVDP QCLQEL 816
    Length:816
    Mass (Da):91,304
    Last modified:November 25, 2008 - v2
    Checksum:iFD61E3C23C99750A
    GO
    Isoform 2 (identifier: Q5R3Z7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-18: SRVLLRTFCLIFGLGA → TGLGAPLFKAWLLIS

    Note: No experimental confirmation available.

    Show »
    Length:815
    Mass (Da):91,125
    Checksum:iE42BE29AFC1553FF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371H → R in CAH91436. 1 PublicationCurated
    Sequence conflicti456 – 4561M → T in CAH91436. 1 PublicationCurated
    Sequence conflicti496 – 4961N → S in CAH91436. 1 PublicationCurated
    Sequence conflicti531 – 5311N → S in CAH93519. 1 PublicationCurated
    Sequence conflicti545 – 5451Q → H in CAH90631. 1 PublicationCurated
    Sequence conflicti616 – 6161D → G in CAH90631. 1 PublicationCurated
    Sequence conflicti683 – 6831T → I in CAH90631. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei3 – 1816SRVLL…FGLGA → TGLGAPLFKAWLLIS in isoform 2. 1 PublicationVSP_035803Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858404 mRNA. Translation: CAH90631.1.
    CR859256 mRNA. Translation: CAH91436.1.
    CR861463 mRNA. Translation: CAH93519.1.
    RefSeqiNP_001125844.1. NM_001132372.1.
    NP_001128913.1. NM_001135441.1.
    UniGeneiPab.19040.

    Genome annotation databases

    GeneIDi100172773.
    100189859.
    KEGGipon:100172773.
    pon:100189859.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858404 mRNA. Translation: CAH90631.1 .
    CR859256 mRNA. Translation: CAH91436.1 .
    CR861463 mRNA. Translation: CAH93519.1 .
    RefSeqi NP_001125844.1. NM_001132372.1.
    NP_001128913.1. NM_001135441.1.
    UniGenei Pab.19040.

    3D structure databases

    ProteinModelPortali Q5R3Z7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100172773.
    100189859.
    KEGGi pon:100172773.
    pon:100189859.

    Organism-specific databases

    CTDi 4753.

    Phylogenomic databases

    HOVERGENi HBG004805.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiNELL2_PONAB
    AccessioniPrimary (citable) accession number: Q5R3Z7
    Secondary accession number(s): Q5R9X4, Q5RC76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3