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Protein

Protein FAM26F

Gene

FAM26F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Pore-forming subunit of a voltage-gated ion channel.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM26F
Gene namesi
Name:FAM26F
Synonyms:C6orf187
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:33391. FAM26F.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387644.

Polymorphism and mutation databases

DMDMi74755904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Protein FAM26FPRO_0000283781Add
BLAST

Proteomic databases

PaxDbiQ5R3K3.
PeptideAtlasiQ5R3K3.
PRIDEiQ5R3K3.

PTM databases

iPTMnetiQ5R3K3.
PhosphoSiteiQ5R3K3.

Expressioni

Gene expression databases

BgeeiENSG00000188820.
CleanExiHS_FAM26F.
ExpressionAtlasiQ5R3K3. baseline and differential.
GenevisibleiQ5R3K3. HS.

Organism-specific databases

HPAiHPA017948.
HPA062365.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357594.

Structurei

3D structure databases

ProteinModelPortaliQ5R3K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGW7. Eukaryota.
ENOG41115FT. LUCA.
GeneTreeiENSGT00530000062796.
HOGENOMiHOG000294134.
HOVERGENiHBG056946.
InParanoidiQ5R3K3.
OMAiPCNQAKA.
OrthoDBiEOG091G0BN1.
PhylomeDBiQ5R3K3.
TreeFamiTF329085.

Family and domain databases

InterProiIPR029569. FAM26.
[Graphical view]
PfamiPF14798. Ca_hom_mod. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5R3K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKFRAVLDL HVKHHSALGY GLVTLLTAGG ERIFSAVAFQ CPCSAAWNLP
60 70 80 90 100
YGLVFLLVPA LALFLLGYVL SARTWRLLTG CCSSARASCG SALRGSLVCT
110 120 130 140 150
QISAAAALAP LTWVAVALLG GAFYECAATG SAAFAQRLCL GRNRSCAAEL
160 170 180 190 200
PLVPCNQAKA SDVQDLLKDL KAQSQVLGWI LIAVVIIILL IFTSVTRCLS
210 220 230 240 250
PVSFLQLKFW KIYLEQEQQI LKSKATEHAT ELAKENIKCF FEGSHPKEYN
260 270 280 290 300
TPSMKEWQQI SSLYTFNPKG QYYSMLHKYV NRKEKTHSIR STEGDTVIPV
310
LGFVDSSGIN STPEL
Length:315
Mass (Da):34,458
Last modified:December 21, 2004 - v1
Checksum:i40059D0CD2D811E7
GO
Isoform 2 (identifier: Q5R3K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
     173-175: QSQ → MFP

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:143
Mass (Da):16,490
Checksum:iBE4F3E587A32C7A5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801G → R.
Corresponds to variant rs1057192 [ dbSNP | Ensembl ].
VAR_053085
Natural varianti100 – 1001T → A.2 Publications
Corresponds to variant rs10784 [ dbSNP | Ensembl ].
VAR_071081
Natural varianti293 – 2931E → K.
Corresponds to variant rs11544160 [ dbSNP | Ensembl ].
VAR_053086

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 172172Missing in isoform 2. CuratedVSP_055698Add
BLAST
Alternative sequencei173 – 1753QSQ → MFP in isoform 2. CuratedVSP_055699

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84488 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48228.1.
BC146842 mRNA. Translation: AAI46843.1.
CCDSiCCDS34519.1. [Q5R3K3-1]
CCDS64506.1. [Q5R3K3-2]
RefSeqiNP_001010919.1. NM_001010919.2. [Q5R3K3-1]
NP_001263389.1. NM_001276460.1. [Q5R3K3-2]
XP_005267056.1. XM_005266999.3. [Q5R3K3-1]
UniGeneiHs.381220.

Genome annotation databases

EnsembliENST00000368605; ENSP00000357594; ENSG00000188820. [Q5R3K3-1]
ENST00000368606; ENSP00000357595; ENSG00000188820. [Q5R3K3-2]
GeneIDi441168.
KEGGihsa:441168.
UCSCiuc003pwv.5. human. [Q5R3K3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84488 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48228.1.
BC146842 mRNA. Translation: AAI46843.1.
CCDSiCCDS34519.1. [Q5R3K3-1]
CCDS64506.1. [Q5R3K3-2]
RefSeqiNP_001010919.1. NM_001010919.2. [Q5R3K3-1]
NP_001263389.1. NM_001276460.1. [Q5R3K3-2]
XP_005267056.1. XM_005266999.3. [Q5R3K3-1]
UniGeneiHs.381220.

3D structure databases

ProteinModelPortaliQ5R3K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357594.

PTM databases

iPTMnetiQ5R3K3.
PhosphoSiteiQ5R3K3.

Polymorphism and mutation databases

DMDMi74755904.

Proteomic databases

PaxDbiQ5R3K3.
PeptideAtlasiQ5R3K3.
PRIDEiQ5R3K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368605; ENSP00000357594; ENSG00000188820. [Q5R3K3-1]
ENST00000368606; ENSP00000357595; ENSG00000188820. [Q5R3K3-2]
GeneIDi441168.
KEGGihsa:441168.
UCSCiuc003pwv.5. human. [Q5R3K3-1]

Organism-specific databases

CTDi441168.
GeneCardsiFAM26F.
HGNCiHGNC:33391. FAM26F.
HPAiHPA017948.
HPA062365.
neXtProtiNX_Q5R3K3.
PharmGKBiPA162387644.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGW7. Eukaryota.
ENOG41115FT. LUCA.
GeneTreeiENSGT00530000062796.
HOGENOMiHOG000294134.
HOVERGENiHBG056946.
InParanoidiQ5R3K3.
OMAiPCNQAKA.
OrthoDBiEOG091G0BN1.
PhylomeDBiQ5R3K3.
TreeFamiTF329085.

Miscellaneous databases

ChiTaRSiFAM26F. human.
GenomeRNAii441168.
PROiQ5R3K3.

Gene expression databases

BgeeiENSG00000188820.
CleanExiHS_FAM26F.
ExpressionAtlasiQ5R3K3. baseline and differential.
GenevisibleiQ5R3K3. HS.

Family and domain databases

InterProiIPR029569. FAM26.
[Graphical view]
PfamiPF14798. Ca_hom_mod. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFA26F_HUMAN
AccessioniPrimary (citable) accession number: Q5R3K3
Secondary accession number(s): B9EJB0, Q5R3K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.